FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283700993> ?p ?o ?g. }

• W4283700993 endingPage "e380" @default.
• W4283700993 startingPage "e370" @default.
• W4283700993 abstract "BackgroundPeripheral surgical trauma can trigger neuroinflammation and ensuing neurological complications, such as delirium. The mechanisms whereby surgery contributes to postoperative neuroinflammation remain unclear and without effective therapies. Here, we developed a microfluidic-assisted blood–brain barrier (BBB) device and tested the effects of omega-3 fatty acids on neuroimmune interactions after orthopaedic surgery.MethodsA microfluidic-assisted BBB device was established using primary human cells. Tight junction proteins, vascular cell adhesion molecule 1 (VCAM-1), BBB permeability, and astrocytic networks were assessed after stimulation with interleukin (IL)-1β and in the presence or absence of a clinically available omega-3 fatty acid emulsion (Omegaven®; Fresenius Kabi, Bad Homburg, Germany). Mice were treated 1 h before orthopaedic surgery with 10 μl g−1 body weight of omega-3 fatty acid emulsion i.v. or equal volumes of saline. Changes in pericytes, perivascular macrophages, BBB opening, microglial activation, and inattention were evaluated.ResultsOmega-3 fatty acids protected barrier permeability, endothelial tight junctions, and VCAM-1 after exposure to IL-1β in the BBB model. In vivo studies confirmed that omega-3 fatty acid treatment inhibited surgery-induced BBB impairment, microglial activation, and delirium-like behaviour. We identified a novel role for pericyte loss and perivascular macrophage activation in mice after surgery, which were rescued by prophylaxis with i.v. omega-3 fatty acids.ConclusionsWe present a new approach to study neuroimmune interactions relevant to perioperative recovery using a microphysiological BBB platform. Changes in barrier function, including dysregulation of pericytes and perivascular macrophages, provide new targets to reduce postoperative delirium." @default.
• W4283700993 created "2022-06-30" @default.
• W4283700993 creator A5000923720 @default.
• W4283700993 creator A5018283068 @default.
• W4283700993 creator A5019664768 @default.
• W4283700993 creator A5026397877 @default.
• W4283700993 creator A5029832903 @default.
• W4283700993 creator A5039212825 @default.
• W4283700993 creator A5039369485 @default.
• W4283700993 creator A5057526670 @default.
• W4283700993 creator A5058760107 @default.
• W4283700993 creator A5068812571 @default.
• W4283700993 creator A5073153977 @default.
• W4283700993 creator A5077276089 @default.
• W4283700993 creator A5082160044 @default.
• W4283700993 creator A5088359046 @default.
• W4283700993 creator A5088907157 @default.
• W4283700993 date "2023-02-01" @default.
• W4283700993 modified "2023-10-06" @default.
• W4283700993 title "Protective effects of omega-3 fatty acids in a blood–brain barrier-on-chip model and on postoperative delirium-like behaviour in mice" @default.
• W4283700993 cites W1885912605 @default.
• W4283700993 cites W1969905245 @default.
• W4283700993 cites W1973553804 @default.
• W4283700993 cites W1999410976 @default.
• W4283700993 cites W2000351290 @default.
• W4283700993 cites W2006035554 @default.
• W4283700993 cites W2010036720 @default.
• W4283700993 cites W2042175711 @default.
• W4283700993 cites W2056856515 @default.
• W4283700993 cites W2090609282 @default.
• W4283700993 cites W2114789645 @default.
• W4283700993 cites W2119251258 @default.
• W4283700993 cites W2125528441 @default.
• W4283700993 cites W2150549175 @default.
• W4283700993 cites W2167739272 @default.
• W4283700993 cites W2200746626 @default.
• W4283700993 cites W2338789749 @default.
• W4283700993 cites W2615290258 @default.
• W4283700993 cites W2622807556 @default.
• W4283700993 cites W2743037209 @default.
• W4283700993 cites W2786608785 @default.
• W4283700993 cites W2793374411 @default.
• W4283700993 cites W2796437903 @default.
• W4283700993 cites W2804685648 @default.
• W4283700993 cites W2812005961 @default.
• W4283700993 cites W2894203109 @default.
• W4283700993 cites W2899108000 @default.
• W4283700993 cites W2906997838 @default.
• W4283700993 cites W2917043336 @default.
• W4283700993 cites W2942762932 @default.
• W4283700993 cites W2951577229 @default.
• W4283700993 cites W2977911154 @default.
• W4283700993 cites W2990043848 @default.
• W4283700993 cites W2991442366 @default.
• W4283700993 cites W2992823221 @default.
• W4283700993 cites W3015680881 @default.
• W4283700993 cites W3018373832 @default.
• W4283700993 cites W3039975419 @default.
• W4283700993 cites W3041325522 @default.
• W4283700993 cites W3048369583 @default.
• W4283700993 cites W3092882340 @default.
• W4283700993 cites W3127180632 @default.
• W4283700993 cites W4210922057 @default.
• W4283700993 cites W4211122792 @default.
• W4283700993 cites W4237417261 @default.
• W4283700993 doi "https://doi.org/10.1016/j.bja.2022.05.025" @default.
• W4283700993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35778276" @default.
• W4283700993 hasPublicationYear "2023" @default.
• W4283700993 type Work @default.
• W4283700993 citedByCount "9" @default.
• W4283700993 countsByYear W42837009932022 @default.
• W4283700993 countsByYear W42837009932023 @default.
• W4283700993 crossrefType "journal-article" @default.
• W4283700993 hasAuthorship W4283700993A5000923720 @default.
• W4283700993 hasAuthorship W4283700993A5018283068 @default.
• W4283700993 hasAuthorship W4283700993A5019664768 @default.
• W4283700993 hasAuthorship W4283700993A5026397877 @default.
• W4283700993 hasAuthorship W4283700993A5029832903 @default.
• W4283700993 hasAuthorship W4283700993A5039212825 @default.
• W4283700993 hasAuthorship W4283700993A5039369485 @default.
• W4283700993 hasAuthorship W4283700993A5057526670 @default.
• W4283700993 hasAuthorship W4283700993A5058760107 @default.
• W4283700993 hasAuthorship W4283700993A5068812571 @default.
• W4283700993 hasAuthorship W4283700993A5073153977 @default.
• W4283700993 hasAuthorship W4283700993A5077276089 @default.
• W4283700993 hasAuthorship W4283700993A5082160044 @default.
• W4283700993 hasAuthorship W4283700993A5088359046 @default.
• W4283700993 hasAuthorship W4283700993A5088907157 @default.
• W4283700993 hasBestOaLocation W42837009931 @default.
• W4283700993 hasConcept C134018914 @default.
• W4283700993 hasConcept C142724271 @default.
• W4283700993 hasConcept C177779419 @default.
• W4283700993 hasConcept C185592680 @default.
• W4283700993 hasConcept C203014093 @default.
• W4283700993 hasConcept C2775962179 @default.
• W4283700993 hasConcept C2776246508 @default.
• W4283700993 hasConcept C2776914184 @default.
• W4283700993 hasConcept C2778402981 @default.

• next