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- W4283704328 abstract "To identify the potential mechanism of Huzhang Tongfeng Granules (HTG) for the treatment of acute gouty arthritis (AGA). First of all, we used network pharmacology to build a network of components-targets of HTG. Secondly, the ClusterONE algorithm was applied to construct a modular network as well as discover hub genes and kernel pathways. Lastly, the MSU crystals-induced AGA mice model was used to verify the hub genes and kernel pathways of HTG. HTG down-regulated the expressions of ADRB3, PIK3CA, FYN, PIK3R1, CASR, PLCG1, SYK, EGFR, and up-regulated MC1R, MC5R. Moreover, according to the kernel clusters enrichment analysis, HTG down-regulated NF-κB and P13K-Akt signaling pathways to ameliorate the AGA mice model. In summary, the potential targets and kernel pathways were proved in this study, supporting the clinical application of HTG for the treatment of AGA." @default.
- W4283704328 created "2022-06-30" @default.
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- W4283704328 date "2022-09-01" @default.
- W4283704328 modified "2023-10-16" @default.
- W4283704328 title "Identification of the potential mechanisms of Huzhang Tongfeng Granules against acute gouty arthritis through network pharmacology and in vivo analysis" @default.
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- W4283704328 doi "https://doi.org/10.1016/j.prmcm.2022.100131" @default.
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