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- W4283705412 endingPage "2048" @default.
- W4283705412 startingPage "2048" @default.
- W4283705412 abstract "Neurogenesis occurs in the brain during embryonic development and throughout adulthood. Neurogenesis occurs in the hippocampus and under normal conditions and persists in two regions of the brain—the subgranular zone (SGZ) in the dentate gyrus of the hippocampus and the subventricular zone (SVZ) of the lateral ventricles. As the critical role in neurogenesis, the neural stem cells have the capacity to differentiate into various cells and to self-renew. This process is controlled through different methods. The mammalian target of rapamycin (mTOR) controls cellular growth, cell proliferation, apoptosis, and autophagy. The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is a major regulator of metabolism, protein quality control, and antioxidative defense, and is linked to neurogenesis. However, dysregulation in neurogenesis, mTOR, and Nrf2 activity have all been associated with neurodegenerative diseases such as Alzheimer’s, Huntington’s, and Parkinson’s. Understanding the role of these complexes in both neurogenesis and neurodegenerative disease could be necessary to develop future therapies. Here, we review both mTOR and Nrf2 complexes, their crosstalk and role in neurogenesis, and their implication in neurodegenerative diseases." @default.
- W4283705412 created "2022-06-30" @default.
- W4283705412 creator A5023703710 @default.
- W4283705412 creator A5027800992 @default.
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- W4283705412 creator A5067671483 @default.
- W4283705412 creator A5071127256 @default.
- W4283705412 creator A5081021817 @default.
- W4283705412 date "2022-06-28" @default.
- W4283705412 modified "2023-10-14" @default.
- W4283705412 title "The Interaction of mTOR and Nrf2 in Neurogenesis and Its Implication in Neurodegenerative Diseases" @default.
- W4283705412 cites W153224349 @default.
- W4283705412 cites W1624064684 @default.
- W4283705412 cites W1977851189 @default.
- W4283705412 cites W1984295096 @default.
- W4283705412 cites W1988772292 @default.
- W4283705412 cites W1990271214 @default.
- W4283705412 cites W1990844894 @default.
- W4283705412 cites W1993827950 @default.
- W4283705412 cites W1996743922 @default.
- W4283705412 cites W2000873101 @default.
- W4283705412 cites W2002726264 @default.
- W4283705412 cites W2009296049 @default.
- W4283705412 cites W2024621777 @default.
- W4283705412 cites W2033178503 @default.
- W4283705412 cites W2043803037 @default.
- W4283705412 cites W2047081046 @default.
- W4283705412 cites W2052985285 @default.
- W4283705412 cites W2053569456 @default.
- W4283705412 cites W2055120349 @default.
- W4283705412 cites W2069460265 @default.
- W4283705412 cites W2071174827 @default.
- W4283705412 cites W2077439063 @default.
- W4283705412 cites W2077569666 @default.
- W4283705412 cites W2079035204 @default.
- W4283705412 cites W2080127092 @default.
- W4283705412 cites W2081541806 @default.
- W4283705412 cites W2100211448 @default.
- W4283705412 cites W2111567059 @default.
- W4283705412 cites W2117691659 @default.
- W4283705412 cites W2128851228 @default.
- W4283705412 cites W2133470905 @default.
- W4283705412 cites W2135046848 @default.
- W4283705412 cites W2135716022 @default.
- W4283705412 cites W2141533937 @default.
- W4283705412 cites W2145520366 @default.
- W4283705412 cites W2150215749 @default.
- W4283705412 cites W2151937556 @default.
- W4283705412 cites W2156073430 @default.
- W4283705412 cites W2165867905 @default.
- W4283705412 cites W2167512703 @default.
- W4283705412 cites W2195088038 @default.
- W4283705412 cites W2207241376 @default.
- W4283705412 cites W2288940883 @default.
- W4283705412 cites W2309675626 @default.
- W4283705412 cites W2336052596 @default.
- W4283705412 cites W2402960573 @default.
- W4283705412 cites W2411905225 @default.
- W4283705412 cites W2487655429 @default.
- W4283705412 cites W2571803537 @default.
- W4283705412 cites W2593816418 @default.
- W4283705412 cites W2731169161 @default.
- W4283705412 cites W2734031337 @default.
- W4283705412 cites W2778730710 @default.
- W4283705412 cites W2791261343 @default.
- W4283705412 cites W2792813804 @default.
- W4283705412 cites W2801345789 @default.
- W4283705412 cites W2804960675 @default.
- W4283705412 cites W2805355170 @default.
- W4283705412 cites W2809270825 @default.
- W4283705412 cites W2810312556 @default.
- W4283705412 cites W2889565370 @default.
- W4283705412 cites W2894685444 @default.
- W4283705412 cites W2901411273 @default.
- W4283705412 cites W2903662406 @default.
- W4283705412 cites W2910097122 @default.
- W4283705412 cites W2923588401 @default.
- W4283705412 cites W2948544179 @default.
- W4283705412 cites W2958665365 @default.
- W4283705412 cites W2995328632 @default.
- W4283705412 cites W3004824763 @default.
- W4283705412 cites W3011014170 @default.
- W4283705412 cites W3011794336 @default.
- W4283705412 cites W3012744916 @default.
- W4283705412 cites W3040982106 @default.
- W4283705412 cites W3046201865 @default.
- W4283705412 cites W3049663475 @default.
- W4283705412 cites W3098227688 @default.
- W4283705412 cites W3126019604 @default.
- W4283705412 cites W3151714526 @default.
- W4283705412 cites W3164236065 @default.
- W4283705412 cites W3198533851 @default.
- W4283705412 cites W4200249038 @default.
- W4283705412 cites W4205281731 @default.
- W4283705412 cites W4210584483 @default.