FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283706044> ?p ?o ?g. }

• W4283706044 endingPage "1433" @default.
• W4283706044 startingPage "1429" @default.
• W4283706044 abstract "Arylamine N-acetyltransferases (NATs) are drug-metabolizing enzymes that are essential for the metabolism of endogenous substrates and xenobiotics. The molecular characteristics of NATs have been extensively investigated in humans but remain to be investigated in common marmosets and pigs, animal species that are often used in drug metabolism studies. In this study, marmoset NAT1 and pig NAT1 cDNAs were isolated from liver samples and were characterized by molecular analyses and drug-metabolism assays. These NAT genes were intronless and formed gene clusters with one other NAT gene in the genome, just as human NAT genes do. Marmoset NAT1 and pig NAT1 amino acid sequences showed high sequence identities (94% and 85%, respectively) to human NAT1. Phylogenetic analysis indicated that marmoset NAT1 and pig NAT1 were more closely clustered with human NATs than with rat or mouse NATs. Marmoset NAT1 and pig NAT1 mRNAs were expressed in all the tissue types analyzed, with the expression levels being highest in the small intestine. Metabolic assays using recombinant proteins found that marmoset NAT1 and pig NAT1 metabolized human NAT substrates p-aminobenzoic acid, 2-aminofluorene, sulfamethazine, and isoniazid. Marmoset NAT1 and pig NAT1 substantially acetylated p-aminobenzoic acid and 2-aminofluorene relevant human NAT1, but their activities were lower toward sulfamethazine and isoniazid than those of the relevant human NAT2. Therefore, marmoset and pig NATs are functional enzymes with molecular similarities to human NAT1, but their substrate specificities, while similar to human NAT1, differ somewhat from human NAT2. SIGNIFICANCE STATEMENT: Marmoset N-acetyltransferase NAT1 and pig NAT1 were identified and showed high sequence identities to human NAT1. These NAT mRNAs were expressed in various tissues. Marmoset and pig NAT1s acetylated typical human NAT substrates, although their substrate specificities differed somewhat from human NAT2. Marmoset NAT1 and pig NAT1 have similarities with human NAT1 in terms of molecular and enzymatic characteristics." @default.
• W4283706044 created "2022-06-30" @default.
• W4283706044 creator A5011871537 @default.
• W4283706044 creator A5017342176 @default.
• W4283706044 creator A5034080524 @default.
• W4283706044 creator A5037843407 @default.
• W4283706044 creator A5044935635 @default.
• W4283706044 creator A5046004509 @default.
• W4283706044 creator A5054023498 @default.
• W4283706044 creator A5072278742 @default.
• W4283706044 creator A5078922881 @default.
• W4283706044 date "2022-06-29" @default.
• W4283706044 modified "2023-09-25" @default.
• W4283706044 title "Molecular and Functional Characterization of <i>N</i>-Acetyltransferases in Common Marmosets and Pigs" @default.
• W4283706044 cites W1565908554 @default.
• W4283706044 cites W1850156578 @default.
• W4283706044 cites W1996770386 @default.
• W4283706044 cites W2002280541 @default.
• W4283706044 cites W2013742927 @default.
• W4283706044 cites W2043203418 @default.
• W4283706044 cites W2052510996 @default.
• W4283706044 cites W2070669906 @default.
• W4283706044 cites W2072084995 @default.
• W4283706044 cites W2084185692 @default.
• W4283706044 cites W2092128596 @default.
• W4283706044 cites W2096358451 @default.
• W4283706044 cites W2107181199 @default.
• W4283706044 cites W2112601493 @default.
• W4283706044 cites W2121820971 @default.
• W4283706044 cites W2123887646 @default.
• W4283706044 cites W2133700798 @default.
• W4283706044 cites W2149298729 @default.
• W4283706044 cites W2176408248 @default.
• W4283706044 cites W2337618189 @default.
• W4283706044 cites W2421272901 @default.
• W4283706044 cites W2613269439 @default.
• W4283706044 cites W2896817570 @default.
• W4283706044 cites W3018859733 @default.
• W4283706044 cites W3036902209 @default.
• W4283706044 doi "https://doi.org/10.1124/dmd.122.000919" @default.
• W4283706044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35768074" @default.
• W4283706044 hasPublicationYear "2022" @default.
• W4283706044 type Work @default.
• W4283706044 citedByCount "0" @default.
• W4283706044 crossrefType "journal-article" @default.
• W4283706044 hasAuthorship W4283706044A5011871537 @default.
• W4283706044 hasAuthorship W4283706044A5017342176 @default.
• W4283706044 hasAuthorship W4283706044A5034080524 @default.
• W4283706044 hasAuthorship W4283706044A5037843407 @default.
• W4283706044 hasAuthorship W4283706044A5044935635 @default.
• W4283706044 hasAuthorship W4283706044A5046004509 @default.
• W4283706044 hasAuthorship W4283706044A5054023498 @default.
• W4283706044 hasAuthorship W4283706044A5072278742 @default.
• W4283706044 hasAuthorship W4283706044A5078922881 @default.
• W4283706044 hasBestOaLocation W42837060441 @default.
• W4283706044 hasConcept C104317684 @default.
• W4283706044 hasConcept C119157956 @default.
• W4283706044 hasConcept C151730666 @default.
• W4283706044 hasConcept C153911025 @default.
• W4283706044 hasConcept C182516595 @default.
• W4283706044 hasConcept C2776453536 @default.
• W4283706044 hasConcept C2778328694 @default.
• W4283706044 hasConcept C31258907 @default.
• W4283706044 hasConcept C41008148 @default.
• W4283706044 hasConcept C55493867 @default.
• W4283706044 hasConcept C86803240 @default.
• W4283706044 hasConceptScore W4283706044C104317684 @default.
• W4283706044 hasConceptScore W4283706044C119157956 @default.
• W4283706044 hasConceptScore W4283706044C151730666 @default.
• W4283706044 hasConceptScore W4283706044C153911025 @default.
• W4283706044 hasConceptScore W4283706044C182516595 @default.
• W4283706044 hasConceptScore W4283706044C2776453536 @default.
• W4283706044 hasConceptScore W4283706044C2778328694 @default.
• W4283706044 hasConceptScore W4283706044C31258907 @default.
• W4283706044 hasConceptScore W4283706044C41008148 @default.
• W4283706044 hasConceptScore W4283706044C55493867 @default.
• W4283706044 hasConceptScore W4283706044C86803240 @default.
• W4283706044 hasIssue "11" @default.
• W4283706044 hasLocation W42837060441 @default.
• W4283706044 hasLocation W42837060442 @default.
• W4283706044 hasOpenAccess W4283706044 @default.
• W4283706044 hasPrimaryLocation W42837060441 @default.
• W4283706044 hasRelatedWork W1752074755 @default.
• W4283706044 hasRelatedWork W2007341591 @default.
• W4283706044 hasRelatedWork W2043045053 @default.
• W4283706044 hasRelatedWork W2053419614 @default.
• W4283706044 hasRelatedWork W2062852759 @default.
• W4283706044 hasRelatedWork W2070695203 @default.
• W4283706044 hasRelatedWork W2103426170 @default.
• W4283706044 hasRelatedWork W2122673726 @default.
• W4283706044 hasRelatedWork W2171277769 @default.
• W4283706044 hasRelatedWork W4283706044 @default.
• W4283706044 hasVolume "50" @default.
• W4283706044 isParatext "false" @default.
• W4283706044 isRetracted "false" @default.
• W4283706044 workType "article" @default.