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- W4283706048 abstract "Abstract Endogenous peptide hormones represent an essential class of biomolecules, which regulate cell–cell communications in diverse physiological processes of organisms. Mass spectrometry (MS) has been developed to be a powerful technology for identifying and quantifying peptides in a highly efficient manner. However, it is difficult to directly identify these peptide hormones due to their diverse characteristics, dynamic regulations, low abundance, and existence in a complicated biological matrix. Here, we summarize and discuss the roles of targeted and untargeted MS in discovering peptide hormones using bioassay‐guided purification, bioinformatics screening, or the peptidomics‐based approach. Although the peptidomics approach is expected to discover novel peptide hormones unbiasedly, only a limited number of successful cases have been reported. The critical challenges and corresponding measures for peptidomics from the steps of sample preparation, peptide extraction, and separation to the MS data acquisition and analysis are also discussed. We also identify emerging technologies and methods that can be integrated into the discovery platform toward the comprehensive study of endogenous peptide hormones." @default.
- W4283706048 created "2022-06-30" @default.
- W4283706048 creator A5025384810 @default.
- W4283706048 creator A5028085908 @default.
- W4283706048 creator A5032828577 @default.
- W4283706048 date "2022-06-29" @default.
- W4283706048 modified "2023-10-17" @default.
- W4283706048 title "Mass spectrometry in the discovery of peptides involved in intercellular communication: From targeted to untargeted peptidomics approaches" @default.
- W4283706048 cites W1025370285 @default.
- W4283706048 cites W1826812957 @default.
- W4283706048 cites W1932563084 @default.
- W4283706048 cites W1966862542 @default.
- W4283706048 cites W1967467171 @default.
- W4283706048 cites W1967772103 @default.
- W4283706048 cites W1968908922 @default.
- W4283706048 cites W1971887998 @default.
- W4283706048 cites W1973107494 @default.
- W4283706048 cites W1977015130 @default.
- W4283706048 cites W1977290961 @default.
- W4283706048 cites W1980767444 @default.
- W4283706048 cites W1984570890 @default.
- W4283706048 cites W1985536048 @default.
- W4283706048 cites W1987692848 @default.
- W4283706048 cites W1988434819 @default.
- W4283706048 cites W1995087873 @default.
- W4283706048 cites W1995478292 @default.
- W4283706048 cites W2000242111 @default.
- W4283706048 cites W2003616201 @default.
- W4283706048 cites W2003805044 @default.
- W4283706048 cites W2003822998 @default.
- W4283706048 cites W2008604118 @default.
- W4283706048 cites W2010966256 @default.
- W4283706048 cites W2014949148 @default.
- W4283706048 cites W2017665520 @default.
- W4283706048 cites W2020584700 @default.
- W4283706048 cites W2027241056 @default.
- W4283706048 cites W2029325590 @default.
- W4283706048 cites W2034413096 @default.
- W4283706048 cites W2034545703 @default.
- W4283706048 cites W2035411948 @default.
- W4283706048 cites W2042148443 @default.
- W4283706048 cites W2044363194 @default.
- W4283706048 cites W2044500962 @default.
- W4283706048 cites W2049310885 @default.
- W4283706048 cites W2051362637 @default.
- W4283706048 cites W2052519819 @default.
- W4283706048 cites W2053807193 @default.
- W4283706048 cites W2056087565 @default.
- W4283706048 cites W2057282070 @default.
- W4283706048 cites W2058082238 @default.
- W4283706048 cites W2058229105 @default.
- W4283706048 cites W2062859898 @default.
- W4283706048 cites W2075023376 @default.
- W4283706048 cites W2078366690 @default.
- W4283706048 cites W2079843936 @default.
- W4283706048 cites W2080992822 @default.
- W4283706048 cites W2081740760 @default.
- W4283706048 cites W2087157360 @default.
- W4283706048 cites W2089066209 @default.
- W4283706048 cites W2090637307 @default.
- W4283706048 cites W2091567597 @default.
- W4283706048 cites W2092367131 @default.
- W4283706048 cites W2096744087 @default.
- W4283706048 cites W2100638755 @default.
- W4283706048 cites W2103444022 @default.
- W4283706048 cites W2108551012 @default.
- W4283706048 cites W2109037877 @default.
- W4283706048 cites W2109787886 @default.
- W4283706048 cites W2109807813 @default.
- W4283706048 cites W2116643047 @default.
- W4283706048 cites W2116901594 @default.
- W4283706048 cites W2118938750 @default.
- W4283706048 cites W2119535826 @default.
- W4283706048 cites W2120032466 @default.
- W4283706048 cites W2131810759 @default.
- W4283706048 cites W2135622703 @default.
- W4283706048 cites W2140125568 @default.
- W4283706048 cites W2140513153 @default.
- W4283706048 cites W2142580593 @default.
- W4283706048 cites W2142821301 @default.
- W4283706048 cites W2143103243 @default.
- W4283706048 cites W2148299987 @default.
- W4283706048 cites W2152529906 @default.
- W4283706048 cites W2163662566 @default.
- W4283706048 cites W2164160006 @default.
- W4283706048 cites W2164969005 @default.
- W4283706048 cites W2168517773 @default.
- W4283706048 cites W2168936979 @default.
- W4283706048 cites W2169193421 @default.
- W4283706048 cites W2171508380 @default.
- W4283706048 cites W2228980293 @default.
- W4283706048 cites W2308104112 @default.
- W4283706048 cites W2314833185 @default.
- W4283706048 cites W2316656800 @default.
- W4283706048 cites W2317806492 @default.
- W4283706048 cites W2322306146 @default.
- W4283706048 cites W2333867588 @default.
- W4283706048 cites W2337706971 @default.
- W4283706048 cites W2346578990 @default.
- W4283706048 cites W2403753581 @default.