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• W4283706226 abstract "Background To completely comprehend the burden of an illness and the success of its treatment, it is essential to analyze the patients’ perspective on health-related quality of life. Because of this, the Primary Sjögren’s Syndrome-Quality of Life questionnaire (PSS-QoL) was developed, which evaluates the disease’s physical and psychosocial effects in PSS patients. Objectives In the literature, there is no Turkish questionnaire evaluating quality of life in patients with PSS. Therefore, the aim of this study was to translate and evaluate cross-culturally adaptation the PSS-QoL into the Turkish language and investigate its convergent validity and reliability in Turkish-speaking population with PSS. Methods Patients completed PSS-QoL questionnaire, the EULAR Sjögren’s Syndrome Patient Reported Index (ESSPRI) and Euro-QoL 5D (EQ-5D). To test the convergent validity of PSS-QoL, correlation between PSS-QoL and EQ-5D and ESSPRI were assessed with Pearson correlation test. In order to investigate the internal consistency and test-retest reliability, Cronbach’s alpha and Intraclass Correlation Coefficient (ICC) values interpreted, respectively. Results Seventy-nine patients with PSS (53.30 + 11.98 years, 74F/5M) were enrolled in the study. Good and moderate correlations were found between the PSS-QoL and ESSPRI (r: 0.818, p<0.001) and EQ-5D-pain/ discomfort (r:0.589, p<0.001). Correlations of subscales of PSS-QoL with subscales of ESSPRI and EQ-5D ranged from fair to strong (Table 1). Cronbach’s alpha and ICC values of the PSS-QoL total score were found to be as 0.955 and 0.914, respectively, indicating excellent reliability. Table 1. Correlations of PSS-QoL and EQ-5D, ESSPRI PSS-QoL Physical Discomfort Dryness Psychosocial total score PSS-QoL PSS-QoL PSS-QoL PSS-QoL EQ-5D-mobility 0.543 ** 0.514 ** 0.678 ** 0.761 ** 0.891 ** EQ-5D-usual activities 0.466 ** 0.342 * 0.371 ** 0.233 * 0.460 ** EQ-5D-pain/discomfort 0.589 ** 0.651 ** 0.710 ** 0.442 ** 0.394 ** EQ-5D-anxiety/depression 0.574 ** 0.570 ** 0.557 ** 0.436 ** 0.439 ** EQ-5D-HS -0.625 ** -0.540 ** -0.495 ** -0.437 ** -0.547 ** ESSPRI-dryness 0.589 ** 0.706 ** 0.448 ** 0.722 ** 0.348 * ESSPRI-pain 0.673 ** 0.694 ** 0.824 ** 0.421 ** 0.494 ** ESSPRI-fatigue 0.780 ** 0.668 ** 0.669 ** 0.497 ** 0.690 ** EQ-5D, Euro-QoL-5 dimension; ESSPRI, EULAR Sjögren’s Syndrome Patient Reported Index; HS, health state; PSS-QoL, Quality of Life in Primary Sjögren’s Syndrome. *p<0.05, **p<0.001. Conclusion This study demonstrated that Turkish version of PSS-QoL is reliable and valid tool to assess quality of life in PSS patients. Therefore, PSS-QoL can be used to assess quality of life in Turkish-speaking PSS patients. References [1]Lackner A, Stradner MH, Hermann J et al. Assessing health-related quality of life in primary Sjögren’s syndrome—the PSS-QoL. In Seminars in arthritis and rheumatism 2018; Vol. 48, No. 1,105-110. [2]Beaton DE, Bombardier C, Guillemin F et al. Guidelines for the process of cross-cultural adaptation of self-report measures. Spine 2000; 25(24):3186-3191. [3]Group, The EuroQol. EuroQol-a new facility for the measurement of health-related quality of life. Health policy 1990; 16.3: 199-208. [4]Seror R, Ravaud P, Mariette X et al. EULAR Sjögren’s Syndrome Patient Reported Index (ESSPRI): development of a consensus patient index for primary Sjögren’s syndrome. Annals of the rheumatic diseases 2011; 70(6), 968-972. Disclosure of Interests None declared" @default.
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• W4283706226 date "2022-05-23" @default.
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• W4283706226 title "AB1529-HPR CROSS-CULTURAL ADAPTATION, RELIABILITY AND CONVERGENT VALIDITY OF THE TURKISH VERSION OF THE PRIMARY SJOGREN’S SYNDROME QUALITY OF LIFE QUESTIONNAIRE" @default.
• W4283706226 doi "https://doi.org/10.1136/annrheumdis-2022-eular.3942" @default.
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