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• W4283711245 endingPage "132297" @default.
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• W4283711245 abstract "Acute lung injury (ALI) is a severe pulmonary inflammatory disease with high morbidity and mortality, whose pathogenesis and treatment are still under exploration. Hydrogen sulfide (H 2 S), a member of gas signal molecules and a biomarker for a variety of diseases, is known to be closely related to ALI. However, the dynamic change of H 2 S levels in this pathological process is still unclear. Herein, a novel fluorescent probe HCy-HSP based on a sulfur-substitution hemicyanine dye was constructed through a facile routine. The probe exhibited an enhanced near-infrared emission compared to the traditional hemicyanine probes and a rapid and significant turn-on fluorescence response to H 2 S. The fluorescence imaging of endogenous H 2 S under different stimulation conditions in normal/cancer cells has been realized by using HCy-HSP . Furthermore, HCy-HSP has been successfully applied to the visualization of H 2 S levels in ALI mice via in vivo /organ near-infrared fluorescence imaging for the first time. The probe could be a promising molecular tool for exploring the physiological role of H 2 S in pulmonary diseases and other pathological activities. A novel fluorescent probe ( HCy-HSP ) for H 2 S was developed based on sulfur-substitution hemicyanine dye. HCy-HSP was used for the real-time fluorescence imaging of H 2 S levels in ALI for the first time, demonstrating as a promising molecular tool for exploring the role of H 2 S in physiological and pathological activities. • A novel probe based on sulfur-substitution hemicyanine dye was developed. • The new probe has a facile and economic synthetic route. • The new probe possesses excellent spectral characteristics toward H 2 S. • The new probe can be applicated in the in situ NIRF imaging of H 2 S. • The new probe can visualize the upregulation of H 2 S in ALI mice for the first time." @default.
• W4283711245 created "2022-06-30" @default.
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• W4283711245 date "2022-10-01" @default.
• W4283711245 modified "2023-10-02" @default.
• W4283711245 title "A novel fluorescent probe for imagining hydrogen sulfide upregulation in acute lung injury" @default.
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• W4283711245 doi "https://doi.org/10.1016/j.snb.2022.132297" @default.
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