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• W4283711293 endingPage "e2219372" @default.
• W4283711293 startingPage "e2219372" @default.
• W4283711293 abstract "<h3>Importance</h3> There has been a growing interest in the use of electronic noses (e-noses) in detecting volatile organic compounds in exhaled breath for the diagnosis of cancer. However, no systematic evaluation has been performed of the overall diagnostic accuracy and methodologic challenges of using e-noses for cancer detection in exhaled breath. <h3>Objective</h3> To provide an overview of the diagnostic accuracy and methodologic challenges of using e-noses for the detection of cancer. <h3>Data Sources</h3> An electronic search was performed in the PubMed and Embase databases (January 1, 2000, to July 1, 2021). <h3>Study Selection</h3> Inclusion criteria were the following: (1) use of e-nose technology, (2) detection of cancer, and (3) analysis of exhaled breath. Exclusion criteria were (1) studies published before 2000; (2) studies not performed in humans; (3) studies not performed in adults; (4) studies that only analyzed biofluids; and (5) studies that exclusively used gas chromatography–mass spectrometry to analyze exhaled breath samples. <h3>Data Extraction and Synthesis</h3> PRISMA guidelines were used for the identification, screening, eligibility, and selection process. Quality assessment was performed using Quality Assessment of Diagnostic Accuracy Studies 2. Generalized mixed-effects bivariate meta-analysis was performed. <h3>Main Outcomes and Measures</h3> Main outcomes were sensitivity, specificity, and mean area under the receiver operating characteristic curve. <h3>Results</h3> This review identified 52 articles with a total of 3677 patients with cancer. All studies were feasibility studies. The sensitivity of e-noses ranged from 48.3% to 95.8% and the specificity from 10.0% to 100.0%. Pooled analysis resulted in a mean (SE) area under the receiver operating characteristic curve of 94% (95% CI, 92%-96%), a sensitivity of 90% (95% CI, 88%-92%), and a specificity of 87% (95% CI, 81%-92%). Considerable heterogeneity existed among the studies because of differences in the selection of patients, endogenous and exogenous factors, and collection of exhaled breath. <h3>Conclusions and Relevance</h3> Results of this review indicate that e-noses have a high diagnostic accuracy for the detection of cancer in exhaled breath. However, most studies were feasibility studies with small sample sizes, a lack of standardization, and a high risk of bias. The lack of standardization and reproducibility of e-nose research should be addressed in future research." @default.
• W4283711293 created "2022-06-30" @default.
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• W4283711293 date "2022-06-29" @default.
• W4283711293 modified "2023-10-01" @default.
• W4283711293 title "Diagnostic Performance of Electronic Noses in Cancer Diagnoses Using Exhaled Breath" @default.
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• W4283711293 doi "https://doi.org/10.1001/jamanetworkopen.2022.19372" @default.
• W4283711293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35767259" @default.
• W4283711293 hasPublicationYear "2022" @default.
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