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• W4283711303 abstract "Background Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder with various clinical manifestations and diverse courses. Lupus nephropathy (LN) is observed in 30-50% of patients with SLE. 10% of patients with LN will develop renal failure (RF). Antiphospholipid antibodies (aPLs) are known for their pro-thrombotic action. According to the literature data, the presence of aPLs can lead to the development of thrombotic microangiopathy and may influence the progression of RF among patients with LN. Objectives The study aims to assess the influence of the presence of aPLs on the course and the progression of LN in long-term observation. Methods We conducted a retrospective analysis of the medical history of 34 patients (pts) with SLE and confirmed lupus nephropathy who are under the constant, long-term care of a rheumatology center. The kidney function (creatinine, estimated glomerular filtration rate; eGFR) was assessed at the beginning of the observation and after approximately 7-10 years. The presence of antiphospholipid antibodies (anticardiolipin antibodies IgG or IgM, anti-beta-2-glycoprotein-I antibodies IgG or IgM, lupus anticoagulants) was taken into consideration. The progression of RF was compared between the pts groups with positive and negative aPLs test results. Results A total of 34 patients (median age at the end of follow-up was 50 years; range 24-82) were included. The majority of patients were female (88.2%). Of these patients, 8 (23.5%) had a positive tests for aPLs many times in their medical history. Considering the progression of RF among patients with positive aPLs, significant statistical differences were observed (p <0,01). Moreover, a statistically significant effect of aCL (p <0.03) and antibodies directed against anti-beta2 glycoprotein I (p <0.04) on the reduction of eGFR in the course of the disease was observed. Conclusion The presence of aPLs is associated with the risk of the deterioration of kidney function in patients with LN. It affects the decrease of eGFR and an increase of the concentration of creatinine in the blood. References [1] Morales E., Galindo M. Et al. Update on Lupus Nephritis: looking for a new vision. Nephron 2021;145:1:1h [2] Zhang J., Zhang Ji., et al. Association of antiphospholipid antibodies with clinical activity and renal pathological activity in patients with lupus nephritis. Lupus. 2021;30(7):1140-1145. [3] K. Talari, U. Anandh, A. Patric. Lupus Nephritis with Coexistent Antiphospholipid Antibodies Associated Nephropathy: A Case Report and Literature Review. Indian J Nephrol. 2018; 28(2): 164–166. Disclosure of Interests Ewa Łyś: None declared, Dorota Suszek: None declared, Maria Majdan Speakers bureau: Medac, Novartis, Sandoz, Consultant of: Sandoz, AstraZeneca" @default.
• W4283711303 created "2022-06-30" @default.
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• W4283711303 date "2022-05-23" @default.
• W4283711303 modified "2023-09-26" @default.
• W4283711303 title "AB0504 DOES THE PRESENCE OF ANTIPHOSPHOLIPID ANTIBODIES AFFECT THE PROGRESSION OF RENAL FAILURE IN PATIENTS WITH LUPUS NEPHROPATHY? LONG-TERM OBSERVATION" @default.
• W4283711303 doi "https://doi.org/10.1136/annrheumdis-2022-eular.2511" @default.
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