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- W4283711408 abstract "Abstract Pluripotent embryonic stem cells have a unique cell cycle structure with a suppressed G1/S restriction point and little differential expression across the cell cycle phases. Here, we evaluate the link between G1/S restriction point activation, phasic gene expression, and cellular differentiation. Expression analysis reveals a gain in phasic gene expression across lineages between embryonic days E7.5 and E9.5. Genetic manipulation of the G1/S restriction point regulators miR-302 and P27 respectively accelerates or delays the onset of phasic gene expression in mouse embryos. Loss of miR-302-mediated p21 or p27 suppression expedites embryonic stem cell differentiation, while a constitutive Cyclin E mutant blocks it. Together, these findings uncover a causal relationship between emergence of the G1/S restriction point with a gain in phasic gene expression and cellular differentiation." @default.
- W4283711408 created "2022-06-30" @default.
- W4283711408 creator A5007889038 @default.
- W4283711408 creator A5030609551 @default.
- W4283711408 creator A5041581060 @default.
- W4283711408 creator A5047721622 @default.
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- W4283711408 creator A5063189733 @default.
- W4283711408 creator A5079309777 @default.
- W4283711408 creator A5084599285 @default.
- W4283711408 date "2022-06-27" @default.
- W4283711408 modified "2023-10-15" @default.
- W4283711408 title "G1/S restriction point coordinates phasic gene expression and cell differentiation" @default.
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