Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283714763> ?p ?o ?g. }
- W4283714763 endingPage "7395" @default.
- W4283714763 startingPage "7380" @default.
- W4283714763 abstract "Abstract Although previous studies have identified several autonomous pathway components that are required for the promotion of flowering, little is known about how these components cooperate. Here, we identified an autonomous pathway complex (AuPC) containing both known components (FLD, LD and SDG26) and previously unknown components (EFL2, EFL4 and APRF1). Loss-of-function mutations of all of these components result in increased FLC expression and delayed flowering. The delayed-flowering phenotype is independent of photoperiod and can be overcome by vernalization, confirming that the complex specifically functions in the autonomous pathway. Chromatin immunoprecipitation combined with sequencing indicated that, in the AuPC mutants, the histone modifications (H3Ac, H3K4me3 and H3K36me3) associated with transcriptional activation are increased, and the histone modification (H3K27me3) associated with transcriptional repression is reduced, suggesting that the AuPC suppresses FLC expression at least partially by regulating these histone modifications. Moreover, we found that the AuPC component SDG26 associates with FLC chromatin via a previously uncharacterized DNA-binding domain and regulates FLC expression and flowering time independently of its histone methyltransferase activity. Together, these results provide a framework for understanding the molecular mechanism by which the autonomous pathway regulates flowering time." @default.
- W4283714763 created "2022-07-01" @default.
- W4283714763 creator A5002275775 @default.
- W4283714763 creator A5004909697 @default.
- W4283714763 creator A5005301813 @default.
- W4283714763 creator A5016254202 @default.
- W4283714763 creator A5030812792 @default.
- W4283714763 creator A5031780490 @default.
- W4283714763 creator A5045848210 @default.
- W4283714763 creator A5052293051 @default.
- W4283714763 creator A5057363581 @default.
- W4283714763 creator A5058965019 @default.
- W4283714763 creator A5058977772 @default.
- W4283714763 creator A5061579277 @default.
- W4283714763 creator A5070805840 @default.
- W4283714763 creator A5075056499 @default.
- W4283714763 date "2022-06-29" @default.
- W4283714763 modified "2023-10-14" @default.
- W4283714763 title "Characterization of an autonomous pathway complex that promotes flowering in <i>Arabidopsis</i>" @default.
- W4283714763 cites W1851394852 @default.
- W4283714763 cites W1937054661 @default.
- W4283714763 cites W1963651550 @default.
- W4283714763 cites W1966455679 @default.
- W4283714763 cites W1974930689 @default.
- W4283714763 cites W1979846192 @default.
- W4283714763 cites W1979936449 @default.
- W4283714763 cites W1980298695 @default.
- W4283714763 cites W1988645862 @default.
- W4283714763 cites W1989379296 @default.
- W4283714763 cites W1990533575 @default.
- W4283714763 cites W1993377849 @default.
- W4283714763 cites W2000331546 @default.
- W4283714763 cites W2000453699 @default.
- W4283714763 cites W2002900187 @default.
- W4283714763 cites W2005370601 @default.
- W4283714763 cites W2005960411 @default.
- W4283714763 cites W2007897769 @default.
- W4283714763 cites W2009205903 @default.
- W4283714763 cites W2010435926 @default.
- W4283714763 cites W2011108579 @default.
- W4283714763 cites W2024071877 @default.
- W4283714763 cites W2025317003 @default.
- W4283714763 cites W2031004332 @default.
- W4283714763 cites W2035736338 @default.
- W4283714763 cites W2041389660 @default.
- W4283714763 cites W2055598782 @default.
- W4283714763 cites W2060725084 @default.
- W4283714763 cites W2062771530 @default.
- W4283714763 cites W2066672169 @default.
- W4283714763 cites W2071636376 @default.
- W4283714763 cites W2073075746 @default.
- W4283714763 cites W2079416395 @default.
- W4283714763 cites W2080079667 @default.
- W4283714763 cites W2081468353 @default.
- W4283714763 cites W2085510068 @default.
- W4283714763 cites W2093762216 @default.
- W4283714763 cites W2094112540 @default.
- W4283714763 cites W2095861170 @default.
- W4283714763 cites W2097664345 @default.
- W4283714763 cites W2098115340 @default.
- W4283714763 cites W2102278945 @default.
- W4283714763 cites W2103165146 @default.
- W4283714763 cites W2112542744 @default.
- W4283714763 cites W2114104545 @default.
- W4283714763 cites W2114800743 @default.
- W4283714763 cites W2120439063 @default.
- W4283714763 cites W2121701144 @default.
- W4283714763 cites W2123217482 @default.
- W4283714763 cites W2124433257 @default.
- W4283714763 cites W2133723991 @default.
- W4283714763 cites W2133757548 @default.
- W4283714763 cites W2138207763 @default.
- W4283714763 cites W2146547152 @default.
- W4283714763 cites W2146648681 @default.
- W4283714763 cites W2146972310 @default.
- W4283714763 cites W2150389521 @default.
- W4283714763 cites W2154193150 @default.
- W4283714763 cites W2163813691 @default.
- W4283714763 cites W2166164324 @default.
- W4283714763 cites W2166248386 @default.
- W4283714763 cites W2168701468 @default.
- W4283714763 cites W2170551349 @default.
- W4283714763 cites W2223486414 @default.
- W4283714763 cites W2272972357 @default.
- W4283714763 cites W2343933956 @default.
- W4283714763 cites W2527274298 @default.
- W4283714763 cites W2538567142 @default.
- W4283714763 cites W2782083867 @default.
- W4283714763 cites W2907241921 @default.
- W4283714763 cites W2931131092 @default.
- W4283714763 cites W2947178636 @default.
- W4283714763 cites W2954716652 @default.
- W4283714763 cites W2990891741 @default.
- W4283714763 cites W2995190168 @default.
- W4283714763 cites W3035481403 @default.
- W4283714763 cites W3133525812 @default.
- W4283714763 cites W3137947769 @default.
- W4283714763 cites W3163537515 @default.