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- W4283716356 abstract "Stress susceptibility could play a role in developing premenstrual anxiety due to abnormalities in the hypothalamus-pituitary-adrenal (HPA) axis and impairments in the GABAA receptors' benzodiazepine (BDZ) site. Hence, we studied the stress-vulnerable Wistar Kyoto rat strain (WKY) to evaluate progesterone withdrawal (PW) effects on anxiety, HPA axis response, and to explore indicators of GABAA functionality in the BDZ site. For five days, ovariectomized WKY rats were administered 2.0 mg/kg of progesterone. Twenty-four hours after the last administration, rats were tested in the anxiety-like burying behavior test (BBT) or elevated plus maze test (EPM), and corticosterone was determined. [3H]Flunitrazepam binding autoradiography served as the BDZ binding site index of the GABAA receptor in amygdala nuclei and hippocampus's dentate gyrus (DG). Finally, different doses of diazepam in PW-WKY rats were tested in the BBT. PW induced anxiety-like behaviors in both BBT and EPM compared with No-PW rats. PW increased corticosterone, but was blunted when combined with PW and BBT. PW increased [3H]Flunitrazepam binding in the DG and central amygdala compared with No-PW rats. Diazepam at a low dose induced an anxiogenic-like response in PW rats, suggesting a paradoxical response to benzodiazepines. Overall, PW induced anxiety-like behavior, a blunted HPA axis response, and higher GABAAR/BZD binding site sensitivity in a stress-vulnerable rat strain. These findings demonstrate the role of stress-susceptibility in GABAAR functionality in a preclinical approximation of PMDD." @default.
- W4283716356 created "2022-07-01" @default.
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- W4283716356 date "2022-06-30" @default.
- W4283716356 modified "2023-10-14" @default.
- W4283716356 title "Anxiety-like Behavior and GABAAR/BDZ Binding Site Response to Progesterone Withdrawal in a Stress-Vulnerable Strain, the Wistar Kyoto Rats" @default.
- W4283716356 cites W15119525 @default.
- W4283716356 cites W1647312149 @default.
- W4283716356 cites W1812497036 @default.
- W4283716356 cites W1905334019 @default.
- W4283716356 cites W1971188127 @default.
- W4283716356 cites W1972695216 @default.
- W4283716356 cites W1976837207 @default.
- W4283716356 cites W1976955039 @default.
- W4283716356 cites W1979454114 @default.
- W4283716356 cites W1982309599 @default.
- W4283716356 cites W1983179844 @default.
- W4283716356 cites W1984594978 @default.
- W4283716356 cites W1985496885 @default.
- W4283716356 cites W1986901635 @default.
- W4283716356 cites W1987089117 @default.
- W4283716356 cites W1989794336 @default.
- W4283716356 cites W199080563 @default.
- W4283716356 cites W1992465786 @default.
- W4283716356 cites W1995222138 @default.
- W4283716356 cites W1995898642 @default.
- W4283716356 cites W1996092905 @default.
- W4283716356 cites W1997286187 @default.
- W4283716356 cites W2001131875 @default.
- W4283716356 cites W2003410981 @default.
- W4283716356 cites W2005082925 @default.
- W4283716356 cites W2005305393 @default.
- W4283716356 cites W2008744891 @default.
- W4283716356 cites W2010364500 @default.
- W4283716356 cites W2016696455 @default.
- W4283716356 cites W2017436597 @default.
- W4283716356 cites W2017738237 @default.
- W4283716356 cites W2024226899 @default.
- W4283716356 cites W2024383350 @default.
- W4283716356 cites W2040115686 @default.
- W4283716356 cites W2041040528 @default.
- W4283716356 cites W2041561931 @default.
- W4283716356 cites W2044075990 @default.
- W4283716356 cites W2051831861 @default.
- W4283716356 cites W2056224205 @default.
- W4283716356 cites W2056932896 @default.
- W4283716356 cites W2061414263 @default.
- W4283716356 cites W2065680302 @default.
- W4283716356 cites W2067275030 @default.
- W4283716356 cites W2070891061 @default.
- W4283716356 cites W2072370095 @default.
- W4283716356 cites W2073164064 @default.
- W4283716356 cites W2074924866 @default.
- W4283716356 cites W2081240745 @default.
- W4283716356 cites W2083552615 @default.
- W4283716356 cites W2087249814 @default.
- W4283716356 cites W2087484885 @default.
- W4283716356 cites W2095116865 @default.
- W4283716356 cites W2096247486 @default.
- W4283716356 cites W2097826755 @default.
- W4283716356 cites W2111787299 @default.
- W4283716356 cites W2114524042 @default.
- W4283716356 cites W2119460554 @default.
- W4283716356 cites W2119677026 @default.
- W4283716356 cites W2121622434 @default.
- W4283716356 cites W2132726881 @default.
- W4283716356 cites W2140449396 @default.
- W4283716356 cites W2146098523 @default.
- W4283716356 cites W2152418588 @default.
- W4283716356 cites W2166277728 @default.
- W4283716356 cites W2170926352 @default.
- W4283716356 cites W2300274411 @default.
- W4283716356 cites W2321223504 @default.
- W4283716356 cites W2327123862 @default.
- W4283716356 cites W2413515606 @default.
- W4283716356 cites W2511307417 @default.
- W4283716356 cites W2518256883 @default.
- W4283716356 cites W2545395265 @default.
- W4283716356 cites W2610289618 @default.
- W4283716356 cites W2766874411 @default.
- W4283716356 cites W2804081205 @default.
- W4283716356 cites W2807484787 @default.
- W4283716356 cites W2944165896 @default.
- W4283716356 cites W2947382661 @default.
- W4283716356 cites W2963456869 @default.
- W4283716356 cites W3004953896 @default.
- W4283716356 cites W3014953336 @default.
- W4283716356 cites W3126370177 @default.
- W4283716356 cites W4200269757 @default.
- W4283716356 cites W4210987687 @default.
- W4283716356 doi "https://doi.org/10.3390/ijms23137259" @default.
- W4283716356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35806264" @default.