Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283720907> ?p ?o ?g. }
- W4283720907 endingPage "17628" @default.
- W4283720907 startingPage "17621" @default.
- W4283720907 abstract "Folic acid tagged and hydrophilic polymer containing solid lipid nanoparticles (SLNs) were formulated for the controlled and targeted delivery of gemcitabine, a hydrophilic drug. Drug loaded SLNs were prepared by double emulsion method and optimized by 32 level factorial design. Then, a hydrophilic polymer, namely, poly(N-vinylcaprolactam) (PVCL) was incorporated in the optimized SLN batch in the first aqueous phase (W1) to obtain solid lipid polymer hybrid nanoparticles (SLPHNs) that were further decorated with folic acid (F-SLPHNs). TEM analysis of SLNs and SLPHNs revealed the spherical shape with no aggregation while SLPHNs showed higher % EE. SLPHNs exhibited limited burst release of gemcitabine compared to SLNs as well as lower overall % release. All the formulations showed good cytocompatibility against MDA-MB-231 cell lines and folic acid-tagged hybrid particles (F-SLPHNs) showed remarkably higher cellular uptake." @default.
- W4283720907 created "2022-07-01" @default.
- W4283720907 creator A5014935936 @default.
- W4283720907 creator A5062052450 @default.
- W4283720907 date "2022-01-01" @default.
- W4283720907 modified "2023-10-14" @default.
- W4283720907 title "Poly(<i>N</i>-vinylcaprolactam) containing solid lipid polymer hybrid nanoparticles for controlled delivery of a hydrophilic drug gemcitabine hydrochloride" @default.
- W4283720907 cites W1440962012 @default.
- W4283720907 cites W1579046626 @default.
- W4283720907 cites W1890647543 @default.
- W4283720907 cites W1964937406 @default.
- W4283720907 cites W1965274188 @default.
- W4283720907 cites W1968631214 @default.
- W4283720907 cites W1994995223 @default.
- W4283720907 cites W2006954662 @default.
- W4283720907 cites W2017317942 @default.
- W4283720907 cites W2020975942 @default.
- W4283720907 cites W2021214738 @default.
- W4283720907 cites W2024210946 @default.
- W4283720907 cites W2029156227 @default.
- W4283720907 cites W2047777040 @default.
- W4283720907 cites W2049975169 @default.
- W4283720907 cites W2054189154 @default.
- W4283720907 cites W2060174297 @default.
- W4283720907 cites W2071730404 @default.
- W4283720907 cites W2073179841 @default.
- W4283720907 cites W2081030247 @default.
- W4283720907 cites W2082591179 @default.
- W4283720907 cites W2095248480 @default.
- W4283720907 cites W2161254114 @default.
- W4283720907 cites W2273495465 @default.
- W4283720907 cites W2283717297 @default.
- W4283720907 cites W2318375363 @default.
- W4283720907 cites W2319837694 @default.
- W4283720907 cites W2464129953 @default.
- W4283720907 cites W2524153263 @default.
- W4283720907 cites W2587902106 @default.
- W4283720907 cites W2599766179 @default.
- W4283720907 cites W2615517716 @default.
- W4283720907 cites W2735073762 @default.
- W4283720907 cites W2746957719 @default.
- W4283720907 cites W2753394065 @default.
- W4283720907 cites W2754938970 @default.
- W4283720907 cites W2765727853 @default.
- W4283720907 cites W2811086539 @default.
- W4283720907 cites W2811214319 @default.
- W4283720907 cites W2811228980 @default.
- W4283720907 cites W2896605861 @default.
- W4283720907 cites W2942469160 @default.
- W4283720907 cites W2967411221 @default.
- W4283720907 cites W2972713173 @default.
- W4283720907 cites W2991180896 @default.
- W4283720907 cites W2993023927 @default.
- W4283720907 cites W3011256086 @default.
- W4283720907 cites W3014461065 @default.
- W4283720907 cites W3023558745 @default.
- W4283720907 cites W3045360690 @default.
- W4283720907 cites W3164694960 @default.
- W4283720907 cites W3174704106 @default.
- W4283720907 cites W4225428238 @default.
- W4283720907 cites W44078951 @default.
- W4283720907 doi "https://doi.org/10.1039/d2ra02845j" @default.
- W4283720907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35765442" @default.
- W4283720907 hasPublicationYear "2022" @default.
- W4283720907 type Work @default.
- W4283720907 citedByCount "1" @default.
- W4283720907 countsByYear W42837209072023 @default.
- W4283720907 crossrefType "journal-article" @default.
- W4283720907 hasAuthorship W4283720907A5014935936 @default.
- W4283720907 hasAuthorship W4283720907A5062052450 @default.
- W4283720907 hasBestOaLocation W42837209071 @default.
- W4283720907 hasConcept C105795698 @default.
- W4283720907 hasConcept C13965031 @default.
- W4283720907 hasConcept C155672457 @default.
- W4283720907 hasConcept C169222746 @default.
- W4283720907 hasConcept C171250308 @default.
- W4283720907 hasConcept C178790620 @default.
- W4283720907 hasConcept C184651966 @default.
- W4283720907 hasConcept C185592680 @default.
- W4283720907 hasConcept C192562407 @default.
- W4283720907 hasConcept C199529486 @default.
- W4283720907 hasConcept C2779820397 @default.
- W4283720907 hasConcept C33923547 @default.
- W4283720907 hasConcept C43617362 @default.
- W4283720907 hasConcept C521977710 @default.
- W4283720907 hasConceptScore W4283720907C105795698 @default.
- W4283720907 hasConceptScore W4283720907C13965031 @default.
- W4283720907 hasConceptScore W4283720907C155672457 @default.
- W4283720907 hasConceptScore W4283720907C169222746 @default.
- W4283720907 hasConceptScore W4283720907C171250308 @default.
- W4283720907 hasConceptScore W4283720907C178790620 @default.
- W4283720907 hasConceptScore W4283720907C184651966 @default.
- W4283720907 hasConceptScore W4283720907C185592680 @default.
- W4283720907 hasConceptScore W4283720907C192562407 @default.
- W4283720907 hasConceptScore W4283720907C199529486 @default.
- W4283720907 hasConceptScore W4283720907C2779820397 @default.
- W4283720907 hasConceptScore W4283720907C33923547 @default.
- W4283720907 hasConceptScore W4283720907C43617362 @default.