FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283721120> ?p ?o ?g. }

• W4283721120 endingPage "1379" @default.
• W4283721120 startingPage "1379" @default.
• W4283721120 abstract "Autophagy is a fundamental housekeeping process by which cells degrade their components to maintain homeostasis. Defects in autophagy have been associated with aging, neurodegeneration and metabolic diseases. Non-alcoholic fatty liver diseases (NAFLDs) are characterized by hepatic fat accumulation with or without inflammation. No treatment for NAFLDs is currently available, but autophagy induction has been proposed as a promising therapeutic strategy. Here, we aimed to design autophagy-inducing particles, using the autophagy-inducing peptide (Tat-Beclin), and achieve liver targeting in vivo, taking NAFLD as a model disease. Polylactic acid (PLA) particles were prepared by nanoprecipitation without any surfactant, followed by surface peptide adsorption. The ability of Tat-Beclin nanoparticles (NP T-B) to modulate autophagy and to decrease intracellular lipid was evaluated in vitro by LC3 immunoblot and using a cellular model of steatosis, respectively. The intracellular localization of particles was evaluated by transmission electron microscopy (TEM). Finally, biodistribution of fluorescent NP T-B was evaluated in vivo using tomography in normal and obese mice. The results showed that NP T-B induce autophagy with a long-lasting and enhanced effect compared to the soluble peptide, and at a ten times lower dose. Intracellular lipid also decreased in a cellular model of NAFLD after treatment with T-B and NP T-B under the same dose conditions. Ultrastructural studies revealed that NP T-B are internalized and located in endosomal, endolysosomal and autolysosomal compartments, while in healthy and obese mice, NP T-B could accumulate for several days in the liver. Given the beneficial effects of autophagy-inducing particles in vitro, and their capacity to target the liver of normal and obese mice, NP T-B could be a promising therapeutic tool for NAFLDs, warranting further in vivo investigation." @default.
• W4283721120 created "2022-07-01" @default.
• W4283721120 creator A5016772544 @default.
• W4283721120 creator A5016887375 @default.
• W4283721120 creator A5019963014 @default.
• W4283721120 creator A5027331985 @default.
• W4283721120 creator A5064631913 @default.
• W4283721120 creator A5072057688 @default.
• W4283721120 creator A5075417029 @default.
• W4283721120 creator A5085780157 @default.
• W4283721120 date "2022-06-29" @default.
• W4283721120 modified "2023-10-14" @default.
• W4283721120 title "Design and Evaluation of Autophagy-Inducing Particles for the Treatment of Abnormal Lipid Accumulation" @default.
• W4283721120 cites W1523693806 @default.
• W4283721120 cites W1537620764 @default.
• W4283721120 cites W1594293927 @default.
• W4283721120 cites W1784425676 @default.
• W4283721120 cites W1939180662 @default.
• W4283721120 cites W1945580055 @default.
• W4283721120 cites W1972517547 @default.
• W4283721120 cites W1988762667 @default.
• W4283721120 cites W1993458861 @default.
• W4283721120 cites W1994823455 @default.
• W4283721120 cites W2001591494 @default.
• W4283721120 cites W2007505836 @default.
• W4283721120 cites W2019144805 @default.
• W4283721120 cites W2027876233 @default.
• W4283721120 cites W2028294113 @default.
• W4283721120 cites W2039419943 @default.
• W4283721120 cites W2043724674 @default.
• W4283721120 cites W2048030072 @default.
• W4283721120 cites W2054745605 @default.
• W4283721120 cites W2072277020 @default.
• W4283721120 cites W2074397923 @default.
• W4283721120 cites W2075614768 @default.
• W4283721120 cites W2081987148 @default.
• W4283721120 cites W2085258486 @default.
• W4283721120 cites W2093863466 @default.
• W4283721120 cites W2105114667 @default.
• W4283721120 cites W2109034822 @default.
• W4283721120 cites W2132027627 @default.
• W4283721120 cites W2141506589 @default.
• W4283721120 cites W2144907950 @default.
• W4283721120 cites W2145084709 @default.
• W4283721120 cites W2155687923 @default.
• W4283721120 cites W2161594732 @default.
• W4283721120 cites W2194304382 @default.
• W4283721120 cites W2214570765 @default.
• W4283721120 cites W2233414233 @default.
• W4283721120 cites W2274637449 @default.
• W4283721120 cites W2278960495 @default.
• W4283721120 cites W2410248520 @default.
• W4283721120 cites W2468626314 @default.
• W4283721120 cites W2536988219 @default.
• W4283721120 cites W2557647482 @default.
• W4283721120 cites W2567043748 @default.
• W4283721120 cites W2736992928 @default.
• W4283721120 cites W2748137738 @default.
• W4283721120 cites W2752326209 @default.
• W4283721120 cites W2782934936 @default.
• W4283721120 cites W2798211916 @default.
• W4283721120 cites W2800923282 @default.
• W4283721120 cites W2806162384 @default.
• W4283721120 cites W2810401535 @default.
• W4283721120 cites W2885265365 @default.
• W4283721120 cites W2889039154 @default.
• W4283721120 cites W2898705711 @default.
• W4283721120 cites W2905781294 @default.
• W4283721120 cites W2907953604 @default.
• W4283721120 cites W2911023351 @default.
• W4283721120 cites W2957095132 @default.
• W4283721120 cites W2964313363 @default.
• W4283721120 cites W2973129446 @default.
• W4283721120 cites W2980789587 @default.
• W4283721120 cites W2987701149 @default.
• W4283721120 cites W3005961874 @default.
• W4283721120 cites W3006028518 @default.
• W4283721120 cites W3031936942 @default.
• W4283721120 cites W3036456250 @default.
• W4283721120 cites W3089615670 @default.
• W4283721120 cites W3120094667 @default.
• W4283721120 cites W3134859178 @default.
• W4283721120 cites W3145371283 @default.
• W4283721120 cites W3180524647 @default.
• W4283721120 cites W4206015613 @default.
• W4283721120 cites W4225622047 @default.
• W4283721120 cites W821936088 @default.
• W4283721120 doi "https://doi.org/10.3390/pharmaceutics14071379" @default.
• W4283721120 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35890275" @default.
• W4283721120 hasPublicationYear "2022" @default.
• W4283721120 type Work @default.
• W4283721120 citedByCount "3" @default.
• W4283721120 countsByYear W42837211202023 @default.
• W4283721120 crossrefType "journal-article" @default.
• W4283721120 hasAuthorship W4283721120A5016772544 @default.
• W4283721120 hasAuthorship W4283721120A5016887375 @default.
• W4283721120 hasAuthorship W4283721120A5019963014 @default.
• W4283721120 hasAuthorship W4283721120A5027331985 @default.

• next