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- W4283723199 abstract "Brassicaceae plants contain glucosinolates, which are hydrolysed by myrosinases to toxic products such as isothiocyanates and nitriles, acting as defences. Herbivores have evolved various detoxification strategies, which are reviewed here. Larvae of Phaedon cochleariae (Coleoptera: Chrysomelidae) metabolise hydrolysis products of benzenic glucosinolates by conjugation with aspartic acid. In this study, we investigated whether P. cochleariae uses the same metabolic pathway for structurally different glucosinolates, whether the metabolism differs between adults and larvae and which hydrolysis products are formed as intermediates. Feeding experiments were performed with leaves of watercress (Nasturtium officinale, Brassicaceae) and pea (Pisum sativum, non-Brassicaceae), to which glucosinolates with structurally different side chains (benzenic, indole or aliphatic) or their hydrolysis products were applied. Samples were analysed by UHPLC-QTOF-MS/MS or TD-GC-MS. The same aspartic acid conjugates as previously identified in larvae were also detected as major metabolites of benzenic glucosinolates in adults. Indol-3-ylmethyl glucosinolate was mainly metabolised to N-(1H-indol-3-ylcarbonyl) glutamic acid in adults and larvae, while the metabolism of 2-propenyl glucosinolate remains unclear. The metabolism may thus proceed primarily via isothiocyanates rather than via nitriles, while the hydrolysis occurs independently of plant myrosinases. A detoxification by conjugation with these amino acids is not yet known from other Brassicaceae-feeders." @default.
- W4283723199 created "2022-07-01" @default.
- W4283723199 creator A5009113361 @default.
- W4283723199 creator A5017295504 @default.
- W4283723199 creator A5062935848 @default.
- W4283723199 date "2022-06-28" @default.
- W4283723199 modified "2023-09-25" @default.
- W4283723199 title "Unique metabolism of different glucosinolates in larvae and adults of a leaf beetle specialised on Brassicaceae" @default.
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- W4283723199 doi "https://doi.org/10.1038/s41598-022-14636-6" @default.
- W4283723199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35764778" @default.
- W4283723199 hasPublicationYear "2022" @default.
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