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- W4283726101 abstract "The innate immune system is the first line of host's defense against invading pathogens. Multiple cellular sensors that detect viral components can induce innate antiviral immune responses. As a result, interferons and pro-inflammatory cytokines are produced which help in the elimination of invading viruses. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) belongs to Coronaviridae family, and has a single-stranded, positive-sense RNA genome. It can infect multiple hosts; in humans, it is responsible for the novel coronavirus disease 2019 (COVID-19). Successful, timely, and appropriate detection of SARS-CoV-2 can be very important for the early generation of the immune response. Several drugs that target the innate immune receptors as well as other signaling molecules generated during the innate immune response are currently being investigated in clinical trials. In this review, we summarized the current knowledge of the mechanisms underlying host sensing and innate immune responses against SARS-CoV-2 infection, as well as the role of innate immune receptors in terms of their therapeutic potential against SARS-CoV-2. Moreover, we discussed the drugs undergoing clinical trials and the FDA approved drugs against SARS-CoV-2. This review will help in understanding the interactions between SARS-CoV-2 and innate immune receptors and thus will point towards new dimensions for the development of new therapeutics, which can be beneficial in the current pandemic." @default.
- W4283726101 created "2022-07-01" @default.
- W4283726101 creator A5020674417 @default.
- W4283726101 creator A5050679596 @default.
- W4283726101 creator A5065346454 @default.
- W4283726101 creator A5072408448 @default.
- W4283726101 creator A5078756021 @default.
- W4283726101 date "2022-06-30" @default.
- W4283726101 modified "2023-09-26" @default.
- W4283726101 title "Therapeutic Targeting of Innate Immune Receptors Against SARS-CoV-2 Infection" @default.
- W4283726101 cites W157071115 @default.
- W4283726101 cites W1952382901 @default.
- W4283726101 cites W1994391392 @default.
- W4283726101 cites W2001757395 @default.
- W4283726101 cites W2004760056 @default.
- W4283726101 cites W2019608583 @default.
- W4283726101 cites W2023309048 @default.
- W4283726101 cites W2024238985 @default.
- W4283726101 cites W2025321617 @default.
- W4283726101 cites W2025495699 @default.
- W4283726101 cites W2030632564 @default.
- W4283726101 cites W2032452247 @default.
- W4283726101 cites W2033023829 @default.
- W4283726101 cites W2049449151 @default.
- W4283726101 cites W2052395914 @default.
- W4283726101 cites W2052408514 @default.
- W4283726101 cites W2060004514 @default.
- W4283726101 cites W2061256139 @default.
- W4283726101 cites W2072115152 @default.
- W4283726101 cites W2080287136 @default.
- W4283726101 cites W2096210882 @default.
- W4283726101 cites W2102500641 @default.
- W4283726101 cites W2109445380 @default.
- W4283726101 cites W2109491705 @default.
- W4283726101 cites W2112876622 @default.
- W4283726101 cites W2118530942 @default.
- W4283726101 cites W2119275893 @default.
- W4283726101 cites W2125491088 @default.
- W4283726101 cites W2126829776 @default.
- W4283726101 cites W2129374849 @default.
- W4283726101 cites W2134219545 @default.
- W4283726101 cites W2137053907 @default.
- W4283726101 cites W2137590150 @default.
- W4283726101 cites W2138560966 @default.
- W4283726101 cites W2146122014 @default.
- W4283726101 cites W2146545211 @default.
- W4283726101 cites W2157339124 @default.
- W4283726101 cites W2165572246 @default.
- W4283726101 cites W2166307459 @default.
- W4283726101 cites W2167623612 @default.
- W4283726101 cites W2202212112 @default.
- W4283726101 cites W2257036949 @default.
- W4283726101 cites W2396730870 @default.
- W4283726101 cites W2465134196 @default.
- W4283726101 cites W2494587789 @default.
- W4283726101 cites W2522054313 @default.
- W4283726101 cites W2522054472 @default.
- W4283726101 cites W2532843373 @default.
- W4283726101 cites W2597943218 @default.
- W4283726101 cites W2605016096 @default.
- W4283726101 cites W2606522716 @default.
- W4283726101 cites W2623756362 @default.
- W4283726101 cites W2763252130 @default.
- W4283726101 cites W2788713245 @default.
- W4283726101 cites W2794127862 @default.
- W4283726101 cites W2808166290 @default.
- W4283726101 cites W2906587554 @default.
- W4283726101 cites W2922370077 @default.
- W4283726101 cites W2947156524 @default.
- W4283726101 cites W2957468385 @default.
- W4283726101 cites W3001456238 @default.
- W4283726101 cites W3005091255 @default.
- W4283726101 cites W3006649197 @default.
- W4283726101 cites W3008142620 @default.
- W4283726101 cites W3009906937 @default.
- W4283726101 cites W3009912996 @default.
- W4283726101 cites W3009976289 @default.
- W4283726101 cites W3010126769 @default.
- W4283726101 cites W3010880616 @default.
- W4283726101 cites W3011093535 @default.
- W4283726101 cites W3011498764 @default.
- W4283726101 cites W3012099172 @default.
- W4283726101 cites W3012415734 @default.
- W4283726101 cites W3013039946 @default.
- W4283726101 cites W3013800395 @default.
- W4283726101 cites W3013843415 @default.
- W4283726101 cites W3014541918 @default.
- W4283726101 cites W3014708904 @default.
- W4283726101 cites W3015189647 @default.
- W4283726101 cites W3016473145 @default.
- W4283726101 cites W3016955027 @default.
- W4283726101 cites W3017231304 @default.
- W4283726101 cites W3017632090 @default.
- W4283726101 cites W3019663170 @default.
- W4283726101 cites W3021577931 @default.
- W4283726101 cites W3022047971 @default.
- W4283726101 cites W3022276126 @default.
- W4283726101 cites W3023475091 @default.
- W4283726101 cites W3023763448 @default.
- W4283726101 cites W3024445339 @default.