Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283726122> ?p ?o ?g. }
- W4283726122 endingPage "100027" @default.
- W4283726122 startingPage "100027" @default.
- W4283726122 abstract "Opioid addiction is a worldwide public health crisis stemming from the well-intentioned efforts of physicians to improve pain management in the 1990’s. The lack of knowledge behind the addictive tendencies of opioids, led to what is now known as the opioid epidemic causing significant social and economic burdens across the globe. Research has been primarily focused on the behavioral components of addiction but has more recently been geared towards examining the role of neurons and glial cells in modulating addiction. Glial cells have been shown to modify the pharmacodynamics of opioids via proinflammatory reactivity, ultimately leading to excitotoxicity, disruption of neuro-homeostasis, and hypersensitivity to pain. It is hypothesized that restoring the neuroprotective capacity of glial cells via targeted therapeutics, will prevent further degeneration of neurons under chronic opioid abuse. Nanoparticle delivery systems are a valued tool in the fight against addiction due to their ability to carry diverse payloads, ability to permeate biological membranes, and ability for controlled release of the payload. This perspective offers insight into the cellular mechanisms underlying addiction, adjusting our focus to highlight the role of glial cells in modulating the efficacy of opioids and the effects of addiction. Moreover, we discuss different avenues in which nanotherapeutics can be optimized to target and increase the neuroprotectant capacity of glial cells to alleviate the burden of opioid toxicity in individuals suffering from chronic opioid addiction." @default.
- W4283726122 created "2022-07-01" @default.
- W4283726122 creator A5012144186 @default.
- W4283726122 creator A5016587556 @default.
- W4283726122 creator A5024358551 @default.
- W4283726122 creator A5061323179 @default.
- W4283726122 creator A5074029763 @default.
- W4283726122 date "2022-12-01" @default.
- W4283726122 modified "2023-10-01" @default.
- W4283726122 title "Restoring the neuroprotective capacity of glial cells under opioid addiction" @default.
- W4283726122 cites W142954314 @default.
- W4283726122 cites W1540277158 @default.
- W4283726122 cites W1608875125 @default.
- W4283726122 cites W1612226764 @default.
- W4283726122 cites W1626809853 @default.
- W4283726122 cites W1883868144 @default.
- W4283726122 cites W1977479596 @default.
- W4283726122 cites W1979764802 @default.
- W4283726122 cites W1982476232 @default.
- W4283726122 cites W1987783006 @default.
- W4283726122 cites W1997980357 @default.
- W4283726122 cites W1998437621 @default.
- W4283726122 cites W1999184142 @default.
- W4283726122 cites W2002675502 @default.
- W4283726122 cites W2014202811 @default.
- W4283726122 cites W2014285566 @default.
- W4283726122 cites W2015198771 @default.
- W4283726122 cites W2030898267 @default.
- W4283726122 cites W2033400860 @default.
- W4283726122 cites W2033815137 @default.
- W4283726122 cites W2035419353 @default.
- W4283726122 cites W2037726739 @default.
- W4283726122 cites W2040128952 @default.
- W4283726122 cites W2040492082 @default.
- W4283726122 cites W2051432588 @default.
- W4283726122 cites W2053566310 @default.
- W4283726122 cites W2068094413 @default.
- W4283726122 cites W2070909089 @default.
- W4283726122 cites W2075585703 @default.
- W4283726122 cites W2076078537 @default.
- W4283726122 cites W2078158817 @default.
- W4283726122 cites W2083810082 @default.
- W4283726122 cites W2087356761 @default.
- W4283726122 cites W2088730075 @default.
- W4283726122 cites W2089155556 @default.
- W4283726122 cites W2089532724 @default.
- W4283726122 cites W2094660330 @default.
- W4283726122 cites W2096688894 @default.
- W4283726122 cites W2103076324 @default.
- W4283726122 cites W2104930749 @default.
- W4283726122 cites W2105772180 @default.
- W4283726122 cites W2114009525 @default.
- W4283726122 cites W2124673849 @default.
- W4283726122 cites W2126365703 @default.
- W4283726122 cites W2138902434 @default.
- W4283726122 cites W2141054513 @default.
- W4283726122 cites W2142580180 @default.
- W4283726122 cites W2153998371 @default.
- W4283726122 cites W2155786710 @default.
- W4283726122 cites W2159578148 @default.
- W4283726122 cites W2164039705 @default.
- W4283726122 cites W2166458266 @default.
- W4283726122 cites W2166571334 @default.
- W4283726122 cites W2187976253 @default.
- W4283726122 cites W2266715434 @default.
- W4283726122 cites W2299144098 @default.
- W4283726122 cites W2329316201 @default.
- W4283726122 cites W2341363697 @default.
- W4283726122 cites W2404695164 @default.
- W4283726122 cites W2462345027 @default.
- W4283726122 cites W2579914997 @default.
- W4283726122 cites W2586662902 @default.
- W4283726122 cites W2615015413 @default.
- W4283726122 cites W2616129231 @default.
- W4283726122 cites W2740416083 @default.
- W4283726122 cites W2767887454 @default.
- W4283726122 cites W2778170606 @default.
- W4283726122 cites W2782970362 @default.
- W4283726122 cites W2905413766 @default.
- W4283726122 cites W2921499324 @default.
- W4283726122 cites W2942908901 @default.
- W4283726122 cites W2948520738 @default.
- W4283726122 cites W2960178638 @default.
- W4283726122 cites W2971073420 @default.
- W4283726122 cites W2974104521 @default.
- W4283726122 cites W2990340965 @default.
- W4283726122 cites W3018943500 @default.
- W4283726122 cites W3026759287 @default.
- W4283726122 cites W3031919541 @default.
- W4283726122 cites W3035601401 @default.
- W4283726122 cites W3048049052 @default.
- W4283726122 cites W3093772814 @default.
- W4283726122 cites W3176970273 @default.
- W4283726122 cites W3187954990 @default.
- W4283726122 cites W4220715273 @default.
- W4283726122 cites W4235358290 @default.
- W4283726122 cites W4244161634 @default.
- W4283726122 cites W70856688 @default.