Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283727516> ?p ?o ?g. }
- W4283727516 endingPage "16" @default.
- W4283727516 startingPage "1" @default.
- W4283727516 abstract "Human gingiva-derived mesenchymal stem cells (GMSCs) are isolated from the gingival propria with promising regenerative, immunomodulatory, and anti-inflammatory properties. Recently, several studies, including ours, have found that GMSCs have the therapeutic potentials of nerve regeneration and skin disorders in various types such as the cell itself, cell-free conditioned medium, or extracellular vesicles (EVs). However, the mechanobiological behavior of GMSCs is closely related to the culture conditions. Therefore, the purpose of this study was to evaluate the function of human GMSCs on imiquimod- (IMQ-) induced murine psoriasis-like skin inflammation in two-dimensional (2D) and three-dimensional (3D) culture conditions. Here, we isolated and characterized GMSCs in 2D and 3D culture conditions and found that GMSCs in 2D and 3D infusion can significantly ameliorate the IMQ-induced murine psoriasis-like skin inflammation, reduce the levels of Th1- and Th17-related cytokines IFN-γ, TNF-α, IL-6, IL-17A, IL-17F, IL-21, and IL-22, and upregulate the percentage of spleen CD25+CD3+ T cells while downregulate the percentage of spleen IL-17+CD3+ T cells. In summary, our novel findings reveal that GMSCs in 2D and 3D infusion may possess therapeutic effects in the treatment of psoriasis." @default.
- W4283727516 created "2022-07-01" @default.
- W4283727516 creator A5005823022 @default.
- W4283727516 creator A5009344306 @default.
- W4283727516 creator A5012323312 @default.
- W4283727516 creator A5027879662 @default.
- W4283727516 creator A5032318915 @default.
- W4283727516 creator A5058049200 @default.
- W4283727516 creator A5074325178 @default.
- W4283727516 creator A5074963172 @default.
- W4283727516 creator A5080042635 @default.
- W4283727516 date "2022-06-30" @default.
- W4283727516 modified "2023-10-14" @default.
- W4283727516 title "Gingiva-Derived Mesenchymal Stem Cells Attenuate Imiquimod- (IMQ-) Induced Murine Psoriasis-Like Skin Inflammation" @default.
- W4283727516 cites W1908801241 @default.
- W4283727516 cites W1939997832 @default.
- W4283727516 cites W1963993157 @default.
- W4283727516 cites W1979782761 @default.
- W4283727516 cites W1997273242 @default.
- W4283727516 cites W2017645555 @default.
- W4283727516 cites W2031979684 @default.
- W4283727516 cites W2095128503 @default.
- W4283727516 cites W2102726602 @default.
- W4283727516 cites W2174359660 @default.
- W4283727516 cites W2231727769 @default.
- W4283727516 cites W2413939564 @default.
- W4283727516 cites W2429184676 @default.
- W4283727516 cites W2468810757 @default.
- W4283727516 cites W2531464697 @default.
- W4283727516 cites W2582481034 @default.
- W4283727516 cites W2765495892 @default.
- W4283727516 cites W2766460886 @default.
- W4283727516 cites W2793331331 @default.
- W4283727516 cites W2801675095 @default.
- W4283727516 cites W2807229846 @default.
- W4283727516 cites W2885587082 @default.
- W4283727516 cites W2888226711 @default.
- W4283727516 cites W2895936275 @default.
- W4283727516 cites W2900083712 @default.
- W4283727516 cites W2902046558 @default.
- W4283727516 cites W2907725736 @default.
- W4283727516 cites W2912016401 @default.
- W4283727516 cites W2945969019 @default.
- W4283727516 cites W2951856415 @default.
- W4283727516 cites W2986482064 @default.
- W4283727516 cites W2995740978 @default.
- W4283727516 cites W3028355101 @default.
- W4283727516 cites W3047765808 @default.
- W4283727516 cites W3093017132 @default.
- W4283727516 cites W3118895525 @default.
- W4283727516 cites W3119029586 @default.
- W4283727516 cites W3154203597 @default.
- W4283727516 cites W2114446914 @default.
- W4283727516 doi "https://doi.org/10.1155/2022/6544514" @default.
- W4283727516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35813890" @default.
- W4283727516 hasPublicationYear "2022" @default.
- W4283727516 type Work @default.
- W4283727516 citedByCount "2" @default.
- W4283727516 countsByYear W42837275162022 @default.
- W4283727516 countsByYear W42837275162023 @default.
- W4283727516 crossrefType "journal-article" @default.
- W4283727516 hasAuthorship W4283727516A5005823022 @default.
- W4283727516 hasAuthorship W4283727516A5009344306 @default.
- W4283727516 hasAuthorship W4283727516A5012323312 @default.
- W4283727516 hasAuthorship W4283727516A5027879662 @default.
- W4283727516 hasAuthorship W4283727516A5032318915 @default.
- W4283727516 hasAuthorship W4283727516A5058049200 @default.
- W4283727516 hasAuthorship W4283727516A5074325178 @default.
- W4283727516 hasAuthorship W4283727516A5074963172 @default.
- W4283727516 hasAuthorship W4283727516A5080042635 @default.
- W4283727516 hasBestOaLocation W42837275161 @default.
- W4283727516 hasConcept C142724271 @default.
- W4283727516 hasConcept C198826908 @default.
- W4283727516 hasConcept C203014093 @default.
- W4283727516 hasConcept C2776090121 @default.
- W4283727516 hasConcept C2776914184 @default.
- W4283727516 hasConcept C2779112978 @default.
- W4283727516 hasConcept C2780564577 @default.
- W4283727516 hasConcept C2780931953 @default.
- W4283727516 hasConcept C71924100 @default.
- W4283727516 hasConcept C79484868 @default.
- W4283727516 hasConcept C8891405 @default.
- W4283727516 hasConceptScore W4283727516C142724271 @default.
- W4283727516 hasConceptScore W4283727516C198826908 @default.
- W4283727516 hasConceptScore W4283727516C203014093 @default.
- W4283727516 hasConceptScore W4283727516C2776090121 @default.
- W4283727516 hasConceptScore W4283727516C2776914184 @default.
- W4283727516 hasConceptScore W4283727516C2779112978 @default.
- W4283727516 hasConceptScore W4283727516C2780564577 @default.
- W4283727516 hasConceptScore W4283727516C2780931953 @default.
- W4283727516 hasConceptScore W4283727516C71924100 @default.
- W4283727516 hasConceptScore W4283727516C79484868 @default.
- W4283727516 hasConceptScore W4283727516C8891405 @default.
- W4283727516 hasFunder F4320337111 @default.
- W4283727516 hasLocation W42837275161 @default.
- W4283727516 hasLocation W42837275162 @default.
- W4283727516 hasLocation W42837275163 @default.
- W4283727516 hasOpenAccess W4283727516 @default.