FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283728877> ?p ?o ?g. }

• W4283728877 endingPage "646" @default.
• W4283728877 startingPage "633" @default.
• W4283728877 abstract "Columnaris is a bacterial disease, found in freshwater fish, caused by Flavobacterium oreochromis. The disease has a devastating impact on a range of cultured and wild freshwater fish species e.g. Lates calcarifer (Asian sea bass), which is a serious economic losses to the freshwater aquaculture in Thailand. The disease can be prevented by an efficacious vaccine, however, no licensed effective vaccine is available to date. Current study was based on the development of a novel mucoadhesive nano-encapsulated vaccine (EncapFlavoNP++), where, cationic lipid-based nanoparticles were combined with an antigen obtained from F. oreochromis. Various parameters including transmission electron microscopy (TEM), physiochemical properties; zeta potential, and polydispersity index were determined. The TEM results depicted well-formed circular-shaped nano-encapsulates complexed with cationic lipid surfactants. The average diameter of the molecules was 200 nm, having a zeta potential of 31.82 mV, while, the polydispersity index (PDI) was 0.31. The in vivo study lasted for 8 weeks, the immunologic and protective potentials of the prepared molecules were determined by challenging the fish for 8 weeks. The most effective dilutions of EncapFlavoNP++ solution were 1:100 and 1:200, which significantly improved the efficacy of the immunity by increasing the level of antibody specific to F. oreochromis. A trend of upregulation was found in the immune-related genes including immunoglobulin M heavy chain (IgM), major histocompatibility complex class IIα molecules (MHC-IIα), and dendritic cell specific transcript (DCs) in gills, skin, liver, peripheral blood lymphocytes (PBLs), head kidneys, and spleen as compared to the control group (P < 0.05 and P < 0.01). Upon immunization with EncapFlavoNP++ solution at the dilution of 1:100 and 1:200, the significant increase in survival rate (SR) and relative percent survival (RPS) were found in fish challenged with virulent F. oreochromis bacterium (SR 72.50% and RPS 62.07) and (SR 65.83% and RPS 52.87), respectively as compared to the control group (P < 0.05). It can be concluded that immunization with EncapFlavoNP++ solution has significant immunologic and protective effects against Columnaris disease. Furthermore, the prepared vaccine candidate has more potential as compared to whole-cell immersion vaccination (FK-WC). It can be used on a large scale in the freshwater aquaculture industry to boost immunity against Columnaris disease." @default.
• W4283728877 created "2022-07-01" @default.
• W4283728877 creator A5004970423 @default.
• W4283728877 creator A5016800785 @default.
• W4283728877 creator A5050880751 @default.
• W4283728877 creator A5052528707 @default.
• W4283728877 creator A5053411305 @default.
• W4283728877 creator A5071646635 @default.
• W4283728877 creator A5076004552 @default.
• W4283728877 creator A5077243615 @default.
• W4283728877 creator A5083544240 @default.
• W4283728877 date "2022-08-01" @default.
• W4283728877 modified "2023-10-14" @default.
• W4283728877 title "Mucoadhesive cationic lipid-based Flavobacterium oreochromis nanoencapsulation enhanced the efficacy of mucoadhesive immersion vaccination against columnaris disease and strengthened immunity in Asian sea bass (Lates calcarifer)" @default.
• W4283728877 cites W1147083762 @default.
• W4283728877 cites W1750491904 @default.
• W4283728877 cites W1809465273 @default.
• W4283728877 cites W1834375700 @default.
• W4283728877 cites W1971552205 @default.
• W4283728877 cites W1976171611 @default.
• W4283728877 cites W1998170448 @default.
• W4283728877 cites W2020246099 @default.
• W4283728877 cites W2030219780 @default.
• W4283728877 cites W2065854756 @default.
• W4283728877 cites W2107277218 @default.
• W4283728877 cites W2122610504 @default.
• W4283728877 cites W2155971233 @default.
• W4283728877 cites W2343215646 @default.
• W4283728877 cites W2549329523 @default.
• W4283728877 cites W2751299023 @default.
• W4283728877 cites W2897065628 @default.
• W4283728877 cites W2903656854 @default.
• W4283728877 cites W2948352041 @default.
• W4283728877 cites W2982053351 @default.
• W4283728877 cites W2991523097 @default.
• W4283728877 cites W3002941810 @default.
• W4283728877 cites W3019625113 @default.
• W4283728877 cites W3097832443 @default.
• W4283728877 cites W3127455321 @default.
• W4283728877 cites W3181876215 @default.
• W4283728877 cites W3209807836 @default.
• W4283728877 cites W4200412033 @default.
• W4283728877 doi "https://doi.org/10.1016/j.fsi.2022.06.059" @default.
• W4283728877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35779812" @default.
• W4283728877 hasPublicationYear "2022" @default.
• W4283728877 type Work @default.
• W4283728877 citedByCount "5" @default.
• W4283728877 countsByYear W42837288772022 @default.
• W4283728877 countsByYear W42837288772023 @default.
• W4283728877 crossrefType "journal-article" @default.
• W4283728877 hasAuthorship W4283728877A5004970423 @default.
• W4283728877 hasAuthorship W4283728877A5016800785 @default.
• W4283728877 hasAuthorship W4283728877A5050880751 @default.
• W4283728877 hasAuthorship W4283728877A5052528707 @default.
• W4283728877 hasAuthorship W4283728877A5053411305 @default.
• W4283728877 hasAuthorship W4283728877A5071646635 @default.
• W4283728877 hasAuthorship W4283728877A5076004552 @default.
• W4283728877 hasAuthorship W4283728877A5077243615 @default.
• W4283728877 hasAuthorship W4283728877A5083544240 @default.
• W4283728877 hasConcept C161153951 @default.
• W4283728877 hasConcept C203014093 @default.
• W4283728877 hasConcept C2778658382 @default.
• W4283728877 hasConcept C2779341262 @default.
• W4283728877 hasConcept C2780008901 @default.
• W4283728877 hasConcept C2909208804 @default.
• W4283728877 hasConcept C505870484 @default.
• W4283728877 hasConcept C86803240 @default.
• W4283728877 hasConcept C8891405 @default.
• W4283728877 hasConcept C89423630 @default.
• W4283728877 hasConceptScore W4283728877C161153951 @default.
• W4283728877 hasConceptScore W4283728877C203014093 @default.
• W4283728877 hasConceptScore W4283728877C2778658382 @default.
• W4283728877 hasConceptScore W4283728877C2779341262 @default.
• W4283728877 hasConceptScore W4283728877C2780008901 @default.
• W4283728877 hasConceptScore W4283728877C2909208804 @default.
• W4283728877 hasConceptScore W4283728877C505870484 @default.
• W4283728877 hasConceptScore W4283728877C86803240 @default.
• W4283728877 hasConceptScore W4283728877C8891405 @default.
• W4283728877 hasConceptScore W4283728877C89423630 @default.
• W4283728877 hasLocation W42837288771 @default.
• W4283728877 hasLocation W42837288772 @default.
• W4283728877 hasOpenAccess W4283728877 @default.
• W4283728877 hasPrimaryLocation W42837288771 @default.
• W4283728877 hasRelatedWork W1973245536 @default.
• W4283728877 hasRelatedWork W1993633862 @default.
• W4283728877 hasRelatedWork W2008224649 @default.
• W4283728877 hasRelatedWork W2066719811 @default.
• W4283728877 hasRelatedWork W2096047933 @default.
• W4283728877 hasRelatedWork W2116240053 @default.
• W4283728877 hasRelatedWork W2743200213 @default.
• W4283728877 hasRelatedWork W2892867497 @default.
• W4283728877 hasRelatedWork W2971250744 @default.
• W4283728877 hasRelatedWork W3033688225 @default.
• W4283728877 hasVolume "127" @default.
• W4283728877 isParatext "false" @default.
• W4283728877 isRetracted "false" @default.
• W4283728877 workType "article" @default.