FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283730485> ?p ?o ?g. }

• W4283730485 endingPage "100347" @default.
• W4283730485 startingPage "100347" @default.
• W4283730485 abstract "Ideal artificial tissue scaffolds should provide an in vitro microenvironment comparable to native human skin tissue to direct cell functions, regulate tissue homeostasis, and promote tissue regeneration. A sandwich-like composite scaffold consisting of a hydrogel layer and two aligned nanofibre layers was fabricated and applied as a wound-healing dressing. Gentamicin was preloaded into the hydrogel middle layer and naturally released for antibacterial activity during the healing period. Nanofibrous layers embedded on the top and bottom surfaces of the hydrogel improved the tensile strength fivefold (1560 ​kPa and 465% strain) while serving as a diffusion barrier to reduce the gentamicin initial burst release (30%-15%). Inspired by the extracellular matrix (ECM), the surface of nanofibre top layer was patterned with triangular microarrays using micro-moulding approach to reflect the multidimensional structure of ECM. Biocompatibility of the scaffold is proven from cytotoxicity and haemolysis studies. Fibroblast cells revealed a highly elongated and consistent alignment modulated by the micropatterned fibrous layer and directed their migration towards the wound area. Excisional wounds treated with the scaffold promoted 97.49% wound closure with low inflammation and rapid re-epithelialization and angiogenesis. This scaffold, with its tailored functionality capable of accelerating wound healing, has high potential in tissue engineering applications." @default.
• W4283730485 created "2022-07-01" @default.
• W4283730485 creator A5016913388 @default.
• W4283730485 creator A5064103323 @default.
• W4283730485 date "2022-12-01" @default.
• W4283730485 modified "2023-10-18" @default.
• W4283730485 title "Accelerating the excisional wound closure by using the patterned microstructural nanofibrous mats/gentamicin-loaded hydrogel composite scaffold" @default.
• W4283730485 cites W1209393649 @default.
• W4283730485 cites W1591691911 @default.
• W4283730485 cites W1597754227 @default.
• W4283730485 cites W1925538698 @default.
• W4283730485 cites W1946396463 @default.
• W4283730485 cites W1978279035 @default.
• W4283730485 cites W1984073671 @default.
• W4283730485 cites W1988881552 @default.
• W4283730485 cites W1997974665 @default.
• W4283730485 cites W2005583277 @default.
• W4283730485 cites W2007845729 @default.
• W4283730485 cites W2019922483 @default.
• W4283730485 cites W2023248222 @default.
• W4283730485 cites W2048739871 @default.
• W4283730485 cites W2077300098 @default.
• W4283730485 cites W2095174228 @default.
• W4283730485 cites W2098153465 @default.
• W4283730485 cites W2104186539 @default.
• W4283730485 cites W2108405037 @default.
• W4283730485 cites W2125933232 @default.
• W4283730485 cites W2130568296 @default.
• W4283730485 cites W2154450820 @default.
• W4283730485 cites W2170271633 @default.
• W4283730485 cites W2353982544 @default.
• W4283730485 cites W2415774251 @default.
• W4283730485 cites W2468224059 @default.
• W4283730485 cites W2482399795 @default.
• W4283730485 cites W251524021 @default.
• W4283730485 cites W2551970192 @default.
• W4283730485 cites W2593422606 @default.
• W4283730485 cites W2773665465 @default.
• W4283730485 cites W2794132598 @default.
• W4283730485 cites W2802031155 @default.
• W4283730485 cites W2802891230 @default.
• W4283730485 cites W2889989959 @default.
• W4283730485 cites W2907149821 @default.
• W4283730485 cites W2944729472 @default.
• W4283730485 cites W2948933189 @default.
• W4283730485 cites W2993171262 @default.
• W4283730485 cites W2996454482 @default.
• W4283730485 cites W3007423819 @default.
• W4283730485 cites W3028948785 @default.
• W4283730485 cites W3044394234 @default.
• W4283730485 cites W3081082453 @default.
• W4283730485 cites W3083964379 @default.
• W4283730485 cites W3088211528 @default.
• W4283730485 cites W3133529120 @default.
• W4283730485 cites W3158121826 @default.
• W4283730485 cites W3168116963 @default.
• W4283730485 cites W3185715914 @default.
• W4283730485 cites W4210247231 @default.
• W4283730485 cites W4210771605 @default.
• W4283730485 cites W4297907671 @default.
• W4283730485 doi "https://doi.org/10.1016/j.mtbio.2022.100347" @default.
• W4283730485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35813981" @default.
• W4283730485 hasPublicationYear "2022" @default.
• W4283730485 type Work @default.
• W4283730485 citedByCount "12" @default.
• W4283730485 countsByYear W42837304852022 @default.
• W4283730485 countsByYear W42837304852023 @default.
• W4283730485 crossrefType "journal-article" @default.
• W4283730485 hasAuthorship W4283730485A5016913388 @default.
• W4283730485 hasAuthorship W4283730485A5064103323 @default.
• W4283730485 hasBestOaLocation W42837304851 @default.
• W4283730485 hasConcept C104779481 @default.
• W4283730485 hasConcept C136229726 @default.
• W4283730485 hasConcept C141071460 @default.
• W4283730485 hasConcept C159985019 @default.
• W4283730485 hasConcept C171056886 @default.
• W4283730485 hasConcept C185592680 @default.
• W4283730485 hasConcept C189165786 @default.
• W4283730485 hasConcept C191897082 @default.
• W4283730485 hasConcept C192562407 @default.
• W4283730485 hasConcept C202751555 @default.
• W4283730485 hasConcept C2777230088 @default.
• W4283730485 hasConcept C2780269544 @default.
• W4283730485 hasConcept C2780381497 @default.
• W4283730485 hasConcept C49892992 @default.
• W4283730485 hasConcept C55493867 @default.
• W4283730485 hasConcept C71924100 @default.
• W4283730485 hasConcept C86803240 @default.
• W4283730485 hasConcept C89429830 @default.
• W4283730485 hasConcept C95444343 @default.
• W4283730485 hasConceptScore W4283730485C104779481 @default.
• W4283730485 hasConceptScore W4283730485C136229726 @default.
• W4283730485 hasConceptScore W4283730485C141071460 @default.
• W4283730485 hasConceptScore W4283730485C159985019 @default.
• W4283730485 hasConceptScore W4283730485C171056886 @default.
• W4283730485 hasConceptScore W4283730485C185592680 @default.
• W4283730485 hasConceptScore W4283730485C189165786 @default.
• W4283730485 hasConceptScore W4283730485C191897082 @default.

• next