FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283730690> ?p ?o ?g. }

• W4283730690 abstract "Drug delivery carriers are considered an encouraging approach for the localized treatment of disease with minimum effect on the surrounding tissue. Particularly, layer-by-layer releasing particles have gained increasing interest for their ability to develop multifunctional systems able to control the release of one or more therapeutical drugs and biomolecules. Although experimental methods can offer the opportunity to establish cause and effect relationships, the data collection can be excessively expensive or/and time-consuming. For a better understanding of the impact of different design conditions on the drug-kinetics and release profile, properly designed mathematical models can be greatly beneficial. In this work, we develop a continuum-scale mathematical model to evaluate the transport and release of a drug from a microparticle based on an inner core covered by a polymeric shell. The present mathematical model includes the dissolution and diffusion of the drug and accounts for a mechanism that takes into consideration the drug biomolecules entrapped into the polymeric shell. We test a sensitivity analysis to evaluate the influence of changing the model conditions on the total system behavior. To prove the effectiveness of this proposed model, we consider the specific application of antibacterial treatment and calibrate the model against the data of the release profile for an antibiotic drug, metronidazole. The results of the numerical simulation show that ∼85% of the drug is released in 230 h, and its release is characterized by two regimes where the drug dissolves, diffuses, and travels the external shell layer at a shorter time, while the drug is released from the shell to the surrounding medium at a longer time. Within the sensitivity analysis, the outer layer diffusivity is more significant than the value of diffusivity in the core, and the increase of the dissolution parameters causes an initial burst release of the drug. Finally, changing the shape of the particle to an ellipse produces an increased percentage of drugs released with an unchanged release time." @default.
• W4283730690 created "2022-07-01" @default.
• W4283730690 creator A5009036030 @default.
• W4283730690 creator A5017201763 @default.
• W4283730690 creator A5026589468 @default.
• W4283730690 creator A5034754651 @default.
• W4283730690 creator A5049151547 @default.
• W4283730690 creator A5087251347 @default.
• W4283730690 date "2022-06-30" @default.
• W4283730690 modified "2023-10-14" @default.
• W4283730690 title "Characterization of the Shells in Layer-By-Layer Nanofunctionalized Particles: A Computational Study" @default.
• W4283730690 cites W1963926939 @default.
• W4283730690 cites W1981860292 @default.
• W4283730690 cites W2000352722 @default.
• W4283730690 cites W2002684795 @default.
• W4283730690 cites W2004123015 @default.
• W4283730690 cites W2005219690 @default.
• W4283730690 cites W2009841111 @default.
• W4283730690 cites W2019558227 @default.
• W4283730690 cites W2022973214 @default.
• W4283730690 cites W2025178477 @default.
• W4283730690 cites W2051805600 @default.
• W4283730690 cites W2060640117 @default.
• W4283730690 cites W2065569312 @default.
• W4283730690 cites W2067222073 @default.
• W4283730690 cites W2084448779 @default.
• W4283730690 cites W2099214910 @default.
• W4283730690 cites W2119305237 @default.
• W4283730690 cites W2135002538 @default.
• W4283730690 cites W2324369776 @default.
• W4283730690 cites W2405140899 @default.
• W4283730690 cites W2572398809 @default.
• W4283730690 cites W2593138990 @default.
• W4283730690 cites W2609227845 @default.
• W4283730690 cites W2766633498 @default.
• W4283730690 cites W2768646562 @default.
• W4283730690 cites W2774217642 @default.
• W4283730690 cites W2779899519 @default.
• W4283730690 cites W2787786456 @default.
• W4283730690 cites W2799333487 @default.
• W4283730690 cites W2801118661 @default.
• W4283730690 cites W2892904025 @default.
• W4283730690 cites W2901344067 @default.
• W4283730690 cites W2901999195 @default.
• W4283730690 cites W2904450966 @default.
• W4283730690 cites W2944229672 @default.
• W4283730690 cites W2972413396 @default.
• W4283730690 cites W3004446569 @default.
• W4283730690 cites W3015540279 @default.
• W4283730690 cites W3082751750 @default.
• W4283730690 cites W3092755311 @default.
• W4283730690 cites W3124176995 @default.
• W4283730690 cites W3165793560 @default.
• W4283730690 cites W3200400133 @default.
• W4283730690 cites W3217716633 @default.
• W4283730690 cites W94944660 @default.
• W4283730690 doi "https://doi.org/10.3389/fbioe.2022.888944" @default.
• W4283730690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35845400" @default.
• W4283730690 hasPublicationYear "2022" @default.
• W4283730690 type Work @default.
• W4283730690 citedByCount "0" @default.
• W4283730690 crossrefType "journal-article" @default.
• W4283730690 hasAuthorship W4283730690A5009036030 @default.
• W4283730690 hasAuthorship W4283730690A5017201763 @default.
• W4283730690 hasAuthorship W4283730690A5026589468 @default.
• W4283730690 hasAuthorship W4283730690A5034754651 @default.
• W4283730690 hasAuthorship W4283730690A5049151547 @default.
• W4283730690 hasAuthorship W4283730690A5087251347 @default.
• W4283730690 hasBestOaLocation W42837306901 @default.
• W4283730690 hasConcept C121332964 @default.
• W4283730690 hasConcept C148898269 @default.
• W4283730690 hasConcept C171250308 @default.
• W4283730690 hasConcept C185592680 @default.
• W4283730690 hasConcept C186060115 @default.
• W4283730690 hasConcept C192562407 @default.
• W4283730690 hasConcept C2779227376 @default.
• W4283730690 hasConcept C2779820397 @default.
• W4283730690 hasConcept C2780035454 @default.
• W4283730690 hasConcept C41008148 @default.
• W4283730690 hasConcept C49853544 @default.
• W4283730690 hasConcept C62520636 @default.
• W4283730690 hasConcept C69357855 @default.
• W4283730690 hasConcept C71924100 @default.
• W4283730690 hasConcept C86803240 @default.
• W4283730690 hasConcept C97355855 @default.
• W4283730690 hasConcept C98274493 @default.
• W4283730690 hasConceptScore W4283730690C121332964 @default.
• W4283730690 hasConceptScore W4283730690C148898269 @default.
• W4283730690 hasConceptScore W4283730690C171250308 @default.
• W4283730690 hasConceptScore W4283730690C185592680 @default.
• W4283730690 hasConceptScore W4283730690C186060115 @default.
• W4283730690 hasConceptScore W4283730690C192562407 @default.
• W4283730690 hasConceptScore W4283730690C2779227376 @default.
• W4283730690 hasConceptScore W4283730690C2779820397 @default.
• W4283730690 hasConceptScore W4283730690C2780035454 @default.
• W4283730690 hasConceptScore W4283730690C41008148 @default.
• W4283730690 hasConceptScore W4283730690C49853544 @default.
• W4283730690 hasConceptScore W4283730690C62520636 @default.
• W4283730690 hasConceptScore W4283730690C69357855 @default.
• W4283730690 hasConceptScore W4283730690C71924100 @default.

• next