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- W4283735010 abstract "Endometriosis is a chronic, inflammatory, estrogen-dependent gynecological disease characterized by the growth of endometrial stromal cells and glands outside the uterine cavity in response to hormones, which commonly occurs in reproductive-age women. Zearalenone (ZEA) is a toxic metabolite produced by Fusarium, which acts as estrogen activity because of the similarity of its structure to estrogen. In this study, we used an endometriosis mouse model: 15 days after ovariectomy, endometrial fragments were sutured on the pelvic wall, and exogenous estrogen was supplied using an estrogen-releasing silicone tube embedded subcutaneously. Mice were treated with different doses of ZEA by gavage for 21 days. The results show that ZEA significantly inhibited the growth of ectopic endometrium in a dose-dependent manner. The proliferation of cells decreased while apoptosis increased in the ectopic tissues of ZEA-treated mice compared to the vehicle group. The expression of estrogen receptor-α and its downstream targets MUC1 and p-AKT decreased, indicating an impaired estrogen signaling activity by ZEA treatment. In addition, the decreased expression of pro-inflammatory cytokine Tnf-α, Il-1β, and Il-6, the lower number of macrophages and neutrophils cells, and the inhibited NF-κB signaling pathway suggest the inflammatory response in the ectopic endometrium was also suppressed by ZEA treatment. However, when the exogenous estrogen supply is removed, ZEA, in turn, plays an estrogen-like role that promotes cell proliferation in the ectopic endometrium. In summary, our data suggest ZEA acts as an antagonist in endometriotic tissue when estrogen is sufficient but turns to estrogenic activity in the absence of estrogen in the development of endometriosis. ZEA also inhibits ectopic tissue growth by inhibiting inflammatory response in the endometriosis model." @default.
- W4283735010 created "2022-07-01" @default.
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- W4283735010 date "2022-08-01" @default.
- W4283735010 modified "2023-10-18" @default.
- W4283735010 title "Zearalenone affects the growth of endometriosis via estrogen signaling and inflammatory pathways" @default.
- W4283735010 cites W1661647511 @default.
- W4283735010 cites W1846980064 @default.
- W4283735010 cites W1968005017 @default.
- W4283735010 cites W1972266551 @default.
- W4283735010 cites W1990135666 @default.
- W4283735010 cites W1990778890 @default.
- W4283735010 cites W1996123579 @default.
- W4283735010 cites W2010229505 @default.
- W4283735010 cites W2014001512 @default.
- W4283735010 cites W2017190024 @default.
- W4283735010 cites W2018969253 @default.
- W4283735010 cites W2020213679 @default.
- W4283735010 cites W2042138395 @default.
- W4283735010 cites W2049184335 @default.
- W4283735010 cites W2049970571 @default.
- W4283735010 cites W2073612486 @default.
- W4283735010 cites W2076450856 @default.
- W4283735010 cites W2087037893 @default.
- W4283735010 cites W2088562758 @default.
- W4283735010 cites W2093705034 @default.
- W4283735010 cites W2101278668 @default.
- W4283735010 cites W2109250334 @default.
- W4283735010 cites W2117803941 @default.
- W4283735010 cites W2118366474 @default.
- W4283735010 cites W2121381144 @default.
- W4283735010 cites W2123606632 @default.
- W4283735010 cites W2134783572 @default.
- W4283735010 cites W2139324170 @default.
- W4283735010 cites W2147203421 @default.
- W4283735010 cites W2152982261 @default.
- W4283735010 cites W2156112336 @default.
- W4283735010 cites W2157100128 @default.
- W4283735010 cites W2164434026 @default.
- W4283735010 cites W2165700542 @default.
- W4283735010 cites W2169528901 @default.
- W4283735010 cites W2186501786 @default.
- W4283735010 cites W2222343781 @default.
- W4283735010 cites W2302261222 @default.
- W4283735010 cites W2331250137 @default.
- W4283735010 cites W2336265371 @default.
- W4283735010 cites W2339993699 @default.
- W4283735010 cites W2413193780 @default.
- W4283735010 cites W2523276611 @default.
- W4283735010 cites W2534688261 @default.
- W4283735010 cites W2556443129 @default.
- W4283735010 cites W2605912824 @default.
- W4283735010 cites W2620117134 @default.
- W4283735010 cites W2625800782 @default.
- W4283735010 cites W2737005433 @default.
- W4283735010 cites W2761252698 @default.
- W4283735010 cites W2784279186 @default.
- W4283735010 cites W2884952568 @default.
- W4283735010 cites W2892735104 @default.
- W4283735010 cites W2904543591 @default.
- W4283735010 cites W2911906887 @default.
- W4283735010 cites W2918985478 @default.
- W4283735010 cites W2921360646 @default.
- W4283735010 cites W2965741381 @default.
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- W4283735010 cites W3120040178 @default.
- W4283735010 cites W3135581839 @default.
- W4283735010 cites W3178774309 @default.
- W4283735010 cites W4211081176 @default.
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- W4283735010 doi "https://doi.org/10.1016/j.ecoenv.2022.113826" @default.
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