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• W4283742387 abstract "The growing size of the end stage renal disease (ESRD) population highlights the need for effective dialysis access. Exhausted native vascular access options have led to increased use of catheters and prosthetic shunts, which are both associated with high risks of access failure and infection. Emerging alternatives include tissue-engineered vascular grafts (TEVG). Here we present the endpoint results for 10 ESRD patients with the scaffold-free tissue-engineered vascular access produced from sheets of extracellular matrix produced in vitro by human cells in culture.Grafts were implanted as arteriovenous shunts in 10 ESRD patients with a complex history of access failure. Follow-up included ultrasound control of graft morphology and function, dialysis efficiency, access failure, intervention rate, as well as immunohistochemical analysis of graft structure.One patient died of unrelated causes and three shunts failed to become useable access grafts during the 3-month maturation phase. The 12-month primary and secondary patency for the other six shunts was 86%. Survival of six shunts functioning as the vascular access was 22 ± 12 months with longest primary patency of 38.6 months. The dialysis event rate of 3.34 per patient-year decreased significantly with the use of this TEVG to 0.67.This living autologous tissue-engineered vascular graft seems to be an alternative to synthetic vascular access options, exhibiting advantages of native arteriovenous fistula." @default.
• W4283742387 created "2022-07-02" @default.
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• W4283742387 date "2022-06-30" @default.
• W4283742387 modified "2023-10-16" @default.
• W4283742387 title "Long-term results of autologous scaffold-free tissue-engineered vascular graft for hemodialysis access" @default.
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• W4283742387 doi "https://doi.org/10.1177/11297298221095994" @default.
• W4283742387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35773955" @default.
• W4283742387 hasPublicationYear "2022" @default.
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