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- W4283745707 startingPage "1383" @default.
- W4283745707 abstract "Decoquinate (DQ) is an antimicrobial agent commonly used as a feed additive for birds for human consumption. Its use as an additive is well established, but DQ has the potential for therapy as an antimicrobial drug for veterinary treatment and its optimized derivatives and/or formulations, mainly nanoformulations, have antimicrobial activity against pathogens that infect humans. However, DQ has a high partition coefficient and low solubility in aqueous fluids, and these biopharmaceutical properties have limited its use in humans. In this review, we highlight the antimicrobial activity and pharmacokinetic properties of DQ and highlight the solutions currently under investigation to overcome these drawbacks. A literature search was conducted focusing on the use of decoquinate against various infectious diseases in humans and animals. The search was conducted in several databases, including scientific and patent databases. Pharmaceutical nanotechnology and medicinal chemistry are the tools of choice to achieve human applications, and most of these applications have been able to improve the biopharmaceutical properties and pharmacokinetic profile of DQ. Based on the results presented here, DQ prototypes could be tested in clinical trials for human application in the coming years." @default.
- W4283745707 created "2022-07-02" @default.
- W4283745707 creator A5003678665 @default.
- W4283745707 creator A5046969441 @default.
- W4283745707 creator A5091286020 @default.
- W4283745707 date "2022-06-30" @default.
- W4283745707 modified "2023-10-14" @default.
- W4283745707 title "Chemical and Pharmacological Properties of Decoquinate: A Review of Its Pharmaceutical Potential and Future Perspectives" @default.
- W4283745707 cites W1241822319 @default.
- W4283745707 cites W1486174925 @default.
- W4283745707 cites W1498305210 @default.
- W4283745707 cites W1783871680 @default.
- W4283745707 cites W1969657209 @default.
- W4283745707 cites W1984325804 @default.
- W4283745707 cites W1985362034 @default.
- W4283745707 cites W1989346459 @default.
- W4283745707 cites W1993385824 @default.
- W4283745707 cites W2000710967 @default.
- W4283745707 cites W2011712948 @default.
- W4283745707 cites W2015112378 @default.
- W4283745707 cites W2015428602 @default.
- W4283745707 cites W2015625237 @default.
- W4283745707 cites W2017094915 @default.
- W4283745707 cites W2021801989 @default.
- W4283745707 cites W2030844388 @default.
- W4283745707 cites W2036068194 @default.
- W4283745707 cites W2037397083 @default.
- W4283745707 cites W2039455972 @default.
- W4283745707 cites W2052456595 @default.
- W4283745707 cites W2052862280 @default.
- W4283745707 cites W2052891531 @default.
- W4283745707 cites W2057046963 @default.
- W4283745707 cites W2059282616 @default.
- W4283745707 cites W2062990982 @default.
- W4283745707 cites W2070600380 @default.
- W4283745707 cites W2074261361 @default.
- W4283745707 cites W2079790453 @default.
- W4283745707 cites W2080231980 @default.
- W4283745707 cites W2080430126 @default.
- W4283745707 cites W2080941702 @default.
- W4283745707 cites W2104071596 @default.
- W4283745707 cites W2109956461 @default.
- W4283745707 cites W2118760345 @default.
- W4283745707 cites W2135130257 @default.
- W4283745707 cites W2142892976 @default.
- W4283745707 cites W2149249443 @default.
- W4283745707 cites W2152653674 @default.
- W4283745707 cites W2168890546 @default.
- W4283745707 cites W230716418 @default.
- W4283745707 cites W2329161831 @default.
- W4283745707 cites W2329888977 @default.
- W4283745707 cites W2330918595 @default.
- W4283745707 cites W2345482934 @default.
- W4283745707 cites W2440524256 @default.
- W4283745707 cites W2534080528 @default.
- W4283745707 cites W2546977698 @default.
- W4283745707 cites W2588952947 @default.
- W4283745707 cites W2590285899 @default.
- W4283745707 cites W2601958560 @default.
- W4283745707 cites W2606729393 @default.
- W4283745707 cites W2640542661 @default.
- W4283745707 cites W2754936959 @default.
- W4283745707 cites W2755393567 @default.
- W4283745707 cites W2766424687 @default.
- W4283745707 cites W2887669231 @default.
- W4283745707 cites W2889447534 @default.
- W4283745707 cites W2893063815 @default.
- W4283745707 cites W2895409242 @default.
- W4283745707 cites W2898821708 @default.
- W4283745707 cites W2907536090 @default.
- W4283745707 cites W2910464727 @default.
- W4283745707 cites W2911711238 @default.
- W4283745707 cites W2916899099 @default.
- W4283745707 cites W2941710734 @default.
- W4283745707 cites W2946972596 @default.
- W4283745707 cites W2966490358 @default.
- W4283745707 cites W2991884919 @default.
- W4283745707 cites W3026177711 @default.
- W4283745707 cites W3043608806 @default.
- W4283745707 cites W3046135215 @default.
- W4283745707 cites W3087467125 @default.
- W4283745707 cites W3107825098 @default.
- W4283745707 cites W3134474529 @default.
- W4283745707 cites W3153371055 @default.
- W4283745707 cites W3171664832 @default.
- W4283745707 cites W3178023815 @default.
- W4283745707 cites W3197177479 @default.
- W4283745707 cites W4206162724 @default.
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- W4283745707 doi "https://doi.org/10.3390/pharmaceutics14071383" @default.
- W4283745707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35890280" @default.
- W4283745707 hasPublicationYear "2022" @default.
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