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• W4283745779 abstract "Abstract The colonization of bacterial pathogens is a major concern in wound infection and becoming a public health issue. Herein, a core-shell structured Ag@MSN (silver core embedded with mesoporous silica, AM)-based nanoplatform was elaborately fabricated to co-load ciprofloxacin (CFL) and tumor necrosis factor-α (TNF-α) small interfering RNA (siTNF-α) (AMPC@siTNF-α) for treating the bacterial-infected wound. The growth of bacterial pathogens was mostly inhibited by released silver ions (Ag + ) and CFL from AMPC@siTNF-α. Meanwhile, the loaded siTNF-α was internalized by macrophage cells, which silenced the expression of TNF-α (a pro-inflammatory cytokine) in macrophage cells and accelerated the wound healing process by reducing inflammation response. In the in vivo wound model, the Escherichia coli (E. coli) -infected wound in mice almost completely disappeared after treatment with AMPC@siTNF-α, and no suppuration symptom was observed during the course of the treatment. Importantly, this nanoplatform had negligible side effects both in vitro and in vivo . Taken together, this study strongly demonstrates the promising potential of AMPC@siTNF-α as a synergistic therapeutic agent for clinical wound infections." @default.
• W4283745779 created "2022-07-02" @default.
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• W4283745779 date "2022-07-01" @default.
• W4283745779 modified "2023-09-29" @default.
• W4283745779 title "Mesoporous silica-coated silver nanoparticles as ciprofloxacin and siRNA co-delivery multifunctional platform for accelerated infected wound healing" @default.
• W4283745779 doi "https://doi.org/10.21203/rs.3.rs-1777499/v1" @default.
• W4283745779 hasPublicationYear "2022" @default.
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