FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283750564> ?p ?o ?g. }

• W4283750564 abstract "Abstract Study question Do children born after assisted reproductive technology (ART) have a higher risk of type 1 diabetes (DM1) compared to non-ART children? Summary answer Children born after ART had similar risk of DM1 compared to non-ART children after adjusting for confounding factors. What is known already ART is associated with higher rates of preterm birth, low birth weight and being born small for gestational age, which are risk factors for future metabolic syndrome. Furthermore, children born after frozen embryo transfer (FET) have an increased risk of being born large for gestational age and with a high birth weight, which has been found to increase the risk of DM1. A previous study on 3,138,540 Swedish children, found no association between ART and DM1 when compared to non-ART children but found an increased risk of DM1 in children born after FET compared to fresh embryo transfer. Study design, size, duration A registry-based cohort study using data from Denmark (birth years 1994–2014), Finland (1990–2014) and Norway (1984–2015) including 77,920 ART-children and 4,511,667 non-ART-children. We investigated the hazard ratio for DM1. Median time to follow-up was 8.2 years (IQR 4.2–13.8) and 13.5 years (IQR 6.9–20.1) in the ART and non-ART group, respectively. Time to follow-up was defined as date of birth until date of DM1 diagnosis, emigration, death or 31st of December 2015, whichever came first. Participants/materials, setting, methods Data originates from a Nordic registry containing information national from ART and patient registries. DM1 was defined as the ICD-10-diagnosis (E10) or ICD-9-diagnosis (250, Finland only). Crude and adjusted hazard ratios (HR) of DM1 were assessed for ART vs. non-ART children, intracytoplasmic sperm injection (ICSI) vs. in vitro fertilization (IVF) and FET vs. fresh embryo transfer using Cox proportional hazard models by adjusting for birthweight, sex, parity, year of birth, maternal diabetes, smoking and education. Main results and the role of chance Overall, 261 (3.3/1000) ART; and 22,074 (4.9/1000) non-ART-children were diagnosed with DM1 within the time to follow-up. We found no increased risk of DM1 in the ART group compared to the non-ART group. The crude HR of DM1 in ART-children was 1.12 (95% CI 0.99–1.26) with non-ART-children being the reference. The adjusted HR was 0.96 (95% CI 0.83–1.11). Since the Finnish cohort had no information on the method of ART, the following results are based on the Danish and Norwegian cohorts only. We found no association between fresh ICSI (34 cases, 2.0/1000) and DM1 compared to fresh IVF (71 cases, 2.7/1000), crude HR 1.13 (95% CI 0.74–1.71) and adjusted HR 0.90 (95% CI 0.49–1.64), fresh IVF being the reference. Furthermore, no increased risk of DM1 was found when comparing FET (cases 10, 1.4/1000) and fresh embryo transfer (cases 110, 2.4/1000). Crude HR of FET was 0.90 (95% CI 0.47–1.72), with the adjusted HR being 0.35 (95% CI 0.09–1.46), fresh embryo transfer being the reference. No assessment of HR in frozen ICSI and IVF was performed due to a limited number of cases. Limitations, reasons for caution The main limitation of the study is the sparse information of the parents, resulting in residual confounding. In the sub-analyses, fresh ICSI vs IVF and fresh vs FET, there is a limited number of cases with DM1. DM1 and type 2 diabetes is not differentiated in ICD-9 classifications. Wider implications of the findings The number of children born after ART is increasing each year and so is children diagnosed with diabetes, hence it is reassuring that the risk of DM1 does not seem to be increased in children born after ART. Our findings are important information when counselling women and men with infertility. Trial registration number Not applicaple" @default.
• W4283750564 created "2022-07-02" @default.
• W4283750564 creator A5006672149 @default.
• W4283750564 creator A5017383203 @default.
• W4283750564 creator A5029939975 @default.
• W4283750564 creator A5030009840 @default.
• W4283750564 creator A5034817114 @default.
• W4283750564 creator A5035945711 @default.
• W4283750564 creator A5063581269 @default.
• W4283750564 creator A5077072537 @default.
• W4283750564 creator A5085234723 @default.
• W4283750564 creator A5085643724 @default.
• W4283750564 date "2022-06-29" @default.
• W4283750564 modified "2023-09-27" @default.
• W4283750564 title "P-767 The risk of type 1 diabetes in ART children – a Nordic cohort study on 4,589,587 liveborn children" @default.
• W4283750564 doi "https://doi.org/10.1093/humrep/deac107.707" @default.
• W4283750564 hasPublicationYear "2022" @default.
• W4283750564 type Work @default.
• W4283750564 citedByCount "0" @default.
• W4283750564 crossrefType "journal-article" @default.
• W4283750564 hasAuthorship W4283750564A5006672149 @default.
• W4283750564 hasAuthorship W4283750564A5017383203 @default.
• W4283750564 hasAuthorship W4283750564A5029939975 @default.
• W4283750564 hasAuthorship W4283750564A5030009840 @default.
• W4283750564 hasAuthorship W4283750564A5034817114 @default.
• W4283750564 hasAuthorship W4283750564A5035945711 @default.
• W4283750564 hasAuthorship W4283750564A5063581269 @default.
• W4283750564 hasAuthorship W4283750564A5077072537 @default.
• W4283750564 hasAuthorship W4283750564A5085234723 @default.
• W4283750564 hasAuthorship W4283750564A5085643724 @default.
• W4283750564 hasBestOaLocation W42837505641 @default.
• W4283750564 hasConcept C126322002 @default.
• W4283750564 hasConcept C131872663 @default.
• W4283750564 hasConcept C187212893 @default.
• W4283750564 hasConcept C201903717 @default.
• W4283750564 hasConcept C207103383 @default.
• W4283750564 hasConcept C2777688143 @default.
• W4283750564 hasConcept C2778376644 @default.
• W4283750564 hasConcept C2779083892 @default.
• W4283750564 hasConcept C2779234561 @default.
• W4283750564 hasConcept C2780938740 @default.
• W4283750564 hasConcept C44249647 @default.
• W4283750564 hasConcept C500014431 @default.
• W4283750564 hasConcept C54355233 @default.
• W4283750564 hasConcept C66322754 @default.
• W4283750564 hasConcept C71924100 @default.
• W4283750564 hasConcept C72563966 @default.
• W4283750564 hasConcept C77350462 @default.
• W4283750564 hasConcept C86803240 @default.
• W4283750564 hasConceptScore W4283750564C126322002 @default.
• W4283750564 hasConceptScore W4283750564C131872663 @default.
• W4283750564 hasConceptScore W4283750564C187212893 @default.
• W4283750564 hasConceptScore W4283750564C201903717 @default.
• W4283750564 hasConceptScore W4283750564C207103383 @default.
• W4283750564 hasConceptScore W4283750564C2777688143 @default.
• W4283750564 hasConceptScore W4283750564C2778376644 @default.
• W4283750564 hasConceptScore W4283750564C2779083892 @default.
• W4283750564 hasConceptScore W4283750564C2779234561 @default.
• W4283750564 hasConceptScore W4283750564C2780938740 @default.
• W4283750564 hasConceptScore W4283750564C44249647 @default.
• W4283750564 hasConceptScore W4283750564C500014431 @default.
• W4283750564 hasConceptScore W4283750564C54355233 @default.
• W4283750564 hasConceptScore W4283750564C66322754 @default.
• W4283750564 hasConceptScore W4283750564C71924100 @default.
• W4283750564 hasConceptScore W4283750564C72563966 @default.
• W4283750564 hasConceptScore W4283750564C77350462 @default.
• W4283750564 hasConceptScore W4283750564C86803240 @default.
• W4283750564 hasIssue "Supplement_1" @default.
• W4283750564 hasLocation W42837505641 @default.
• W4283750564 hasOpenAccess W4283750564 @default.
• W4283750564 hasPrimaryLocation W42837505641 @default.
• W4283750564 hasRelatedWork W1560076786 @default.
• W4283750564 hasRelatedWork W1975207777 @default.
• W4283750564 hasRelatedWork W2050860786 @default.
• W4283750564 hasRelatedWork W2159123758 @default.
• W4283750564 hasRelatedWork W2168647818 @default.
• W4283750564 hasRelatedWork W2397969243 @default.
• W4283750564 hasRelatedWork W4200472551 @default.
• W4283750564 hasRelatedWork W4213125336 @default.
• W4283750564 hasRelatedWork W4213308035 @default.
• W4283750564 hasRelatedWork W2735401012 @default.
• W4283750564 hasVolume "37" @default.
• W4283750564 isParatext "false" @default.
• W4283750564 isRetracted "false" @default.
• W4283750564 workType "article" @default.