Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283753287> ?p ?o ?g. }
- W4283753287 endingPage "128877" @default.
- W4283753287 startingPage "128877" @default.
- W4283753287 abstract "Aiming to discover novel antifungal agents, a series of 2‑substituted‑4‑amino-quinolines and -quinazoline were prepared and characterized using IR, 1H NMR, 13C NMR, and HRMS spectroscopic techniques. Their antifungal activities against four invasive fungi were evaluated, and the results revealed that some of the target compounds exhibited moderate to excellent inhibitory potencies. The most promising compounds III11, III14, III15, and III23 exhibited potent and broad-spectrum antifungal activities with MIC values of 4-32 μg/mL. The mechanism studies showed that compound III11 (N,2-di-p-tolylquinolin-4-amine hydrochloride) did not play antifungal potency by disrupting fungal membrane, which was quite different from many traditional membrane-active antifungal drugs. Meanwhile, III11 also demonstrated a low likelihood of inducing resistance, and excellent stability in mouse plasma. In addition, some interesting structure-activity relationships (SARs) were also discussed. These results suggest that some 4‑aminoquinolines may serve as new and promising candidates for further antifungal drug discovery." @default.
- W4283753287 created "2022-07-02" @default.
- W4283753287 creator A5026494478 @default.
- W4283753287 creator A5038327626 @default.
- W4283753287 creator A5050180063 @default.
- W4283753287 creator A5055216706 @default.
- W4283753287 creator A5060775764 @default.
- W4283753287 creator A5061992539 @default.
- W4283753287 date "2022-09-01" @default.
- W4283753287 modified "2023-10-17" @default.
- W4283753287 title "Synthesis and biological evaluation of new 2‑substituted‑4‑amino-quinolines and -quinazoline as potential antifungal agents" @default.
- W4283753287 cites W1816481610 @default.
- W4283753287 cites W2107794472 @default.
- W4283753287 cites W2400575045 @default.
- W4283753287 cites W2516301883 @default.
- W4283753287 cites W2589481236 @default.
- W4283753287 cites W2611710778 @default.
- W4283753287 cites W2619196045 @default.
- W4283753287 cites W2621025690 @default.
- W4283753287 cites W2764102065 @default.
- W4283753287 cites W2766061760 @default.
- W4283753287 cites W2804572516 @default.
- W4283753287 cites W2889011268 @default.
- W4283753287 cites W2905792532 @default.
- W4283753287 cites W2906159259 @default.
- W4283753287 cites W2914478931 @default.
- W4283753287 cites W2974377858 @default.
- W4283753287 cites W2986297431 @default.
- W4283753287 cites W3003450206 @default.
- W4283753287 cites W3006793634 @default.
- W4283753287 cites W3011366455 @default.
- W4283753287 cites W3048461046 @default.
- W4283753287 cites W3080669837 @default.
- W4283753287 cites W3087478168 @default.
- W4283753287 cites W3098849776 @default.
- W4283753287 cites W3110943759 @default.
- W4283753287 cites W3110945670 @default.
- W4283753287 cites W3115360785 @default.
- W4283753287 cites W3119849765 @default.
- W4283753287 cites W3120498776 @default.
- W4283753287 cites W3123893662 @default.
- W4283753287 cites W3126785111 @default.
- W4283753287 cites W3133778573 @default.
- W4283753287 cites W3138453702 @default.
- W4283753287 cites W3149268094 @default.
- W4283753287 cites W3159058049 @default.
- W4283753287 cites W3164317216 @default.
- W4283753287 cites W3196171030 @default.
- W4283753287 doi "https://doi.org/10.1016/j.bmcl.2022.128877" @default.
- W4283753287 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35788035" @default.
- W4283753287 hasPublicationYear "2022" @default.
- W4283753287 type Work @default.
- W4283753287 citedByCount "9" @default.
- W4283753287 countsByYear W42837532872022 @default.
- W4283753287 countsByYear W42837532872023 @default.
- W4283753287 crossrefType "journal-article" @default.
- W4283753287 hasAuthorship W4283753287A5026494478 @default.
- W4283753287 hasAuthorship W4283753287A5038327626 @default.
- W4283753287 hasAuthorship W4283753287A5050180063 @default.
- W4283753287 hasAuthorship W4283753287A5055216706 @default.
- W4283753287 hasAuthorship W4283753287A5060775764 @default.
- W4283753287 hasAuthorship W4283753287A5061992539 @default.
- W4283753287 hasConcept C103319777 @default.
- W4283753287 hasConcept C116073593 @default.
- W4283753287 hasConcept C131779359 @default.
- W4283753287 hasConcept C163111631 @default.
- W4283753287 hasConcept C176947019 @default.
- W4283753287 hasConcept C178790620 @default.
- W4283753287 hasConcept C185592680 @default.
- W4283753287 hasConcept C193042331 @default.
- W4283753287 hasConcept C202751555 @default.
- W4283753287 hasConcept C21951064 @default.
- W4283753287 hasConcept C2778866207 @default.
- W4283753287 hasConcept C2779548794 @default.
- W4283753287 hasConcept C2991737395 @default.
- W4283753287 hasConcept C55493867 @default.
- W4283753287 hasConcept C57992300 @default.
- W4283753287 hasConcept C71240020 @default.
- W4283753287 hasConcept C86803240 @default.
- W4283753287 hasConcept C89423630 @default.
- W4283753287 hasConceptScore W4283753287C103319777 @default.
- W4283753287 hasConceptScore W4283753287C116073593 @default.
- W4283753287 hasConceptScore W4283753287C131779359 @default.
- W4283753287 hasConceptScore W4283753287C163111631 @default.
- W4283753287 hasConceptScore W4283753287C176947019 @default.
- W4283753287 hasConceptScore W4283753287C178790620 @default.
- W4283753287 hasConceptScore W4283753287C185592680 @default.
- W4283753287 hasConceptScore W4283753287C193042331 @default.
- W4283753287 hasConceptScore W4283753287C202751555 @default.
- W4283753287 hasConceptScore W4283753287C21951064 @default.
- W4283753287 hasConceptScore W4283753287C2778866207 @default.
- W4283753287 hasConceptScore W4283753287C2779548794 @default.
- W4283753287 hasConceptScore W4283753287C2991737395 @default.
- W4283753287 hasConceptScore W4283753287C55493867 @default.
- W4283753287 hasConceptScore W4283753287C57992300 @default.
- W4283753287 hasConceptScore W4283753287C71240020 @default.
- W4283753287 hasConceptScore W4283753287C86803240 @default.
- W4283753287 hasConceptScore W4283753287C89423630 @default.