FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283754016> ?p ?o ?g. }

• W4283754016 endingPage "2089" @default.
• W4283754016 startingPage "2089" @default.
• W4283754016 abstract "L-PRF is an autologous blood-derived biomaterial (ABDB) capable of releasing biologically active agents to promote healing. Little is known about its release profile of growth factors (GFs), cytokines, and MMPs. This study reported the in vitro and ex vivo release kinetics of GFs, cytokines, and MMPs from L-PRF at 6, 24, 72, and 168 h. The in vitro release rates of PDGF, TGF-β1, EGF, FGF-2, VEGF, and MMPs decreased over time with different rates, while those of IL-1β, IL-6, TNF-α, IL-8, and IL-10 were low at 6 h and then increased rapidly for up to 24 h and subsequently decreased. Of note, the release rates of the GFs followed first-order kinetics both in vitro and ex vivo. Higher rates of release were found ex vivo, suggesting that significant amounts of GFs were produced by the local cells within the wound. In addition, the half-life times of GFs locally produced in the wound, including PDGF-AA, PDGF-AB/BB, and VEGF, were significantly extended (p < 0.05). This work demonstrates that L-PRF can sustain the release of GFs and cytokines for up to 7 days, and it shows that the former can activate cells to produce additional mediators and amplify the communication network for optimizing the wound environment, thereby enhancing healing." @default.
• W4283754016 created "2022-07-02" @default.
• W4283754016 creator A5000172599 @default.
• W4283754016 creator A5019340563 @default.
• W4283754016 creator A5029550343 @default.
• W4283754016 creator A5073733134 @default.
• W4283754016 creator A5081122871 @default.
• W4283754016 date "2022-06-30" @default.
• W4283754016 modified "2023-10-03" @default.
• W4283754016 title "In Vitro and Ex Vivo Kinetic Release Profile of Growth Factors and Cytokines from Leucocyte- and Platelet-Rich Fibrin (L-PRF) Preparations" @default.
• W4283754016 cites W1509347720 @default.
• W4283754016 cites W1949832432 @default.
• W4283754016 cites W1978825144 @default.
• W4283754016 cites W1990213925 @default.
• W4283754016 cites W2038327247 @default.
• W4283754016 cites W2089692311 @default.
• W4283754016 cites W2097836091 @default.
• W4283754016 cites W2252857368 @default.
• W4283754016 cites W2282450682 @default.
• W4283754016 cites W2295353058 @default.
• W4283754016 cites W2338488578 @default.
• W4283754016 cites W2484410704 @default.
• W4283754016 cites W2584707707 @default.
• W4283754016 cites W2609539491 @default.
• W4283754016 cites W2617852027 @default.
• W4283754016 cites W2771627622 @default.
• W4283754016 cites W2807308263 @default.
• W4283754016 cites W2887528329 @default.
• W4283754016 cites W2895314600 @default.
• W4283754016 cites W2912875180 @default.
• W4283754016 cites W2921097418 @default.
• W4283754016 cites W2969390796 @default.
• W4283754016 cites W3034738711 @default.
• W4283754016 cites W3084661121 @default.
• W4283754016 cites W3086525130 @default.
• W4283754016 cites W3091781752 @default.
• W4283754016 cites W3121446805 @default.
• W4283754016 cites W3176564191 @default.
• W4283754016 cites W3213571094 @default.
• W4283754016 cites W4283373548 @default.
• W4283754016 doi "https://doi.org/10.3390/cells11132089" @default.
• W4283754016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35805173" @default.
• W4283754016 hasPublicationYear "2022" @default.
• W4283754016 type Work @default.
• W4283754016 citedByCount "4" @default.
• W4283754016 countsByYear W42837540162022 @default.
• W4283754016 countsByYear W42837540162023 @default.
• W4283754016 crossrefType "journal-article" @default.
• W4283754016 hasAuthorship W4283754016A5000172599 @default.
• W4283754016 hasAuthorship W4283754016A5019340563 @default.
• W4283754016 hasAuthorship W4283754016A5029550343 @default.
• W4283754016 hasAuthorship W4283754016A5073733134 @default.
• W4283754016 hasAuthorship W4283754016A5081122871 @default.
• W4283754016 hasBestOaLocation W42837540161 @default.
• W4283754016 hasConcept C109523444 @default.
• W4283754016 hasConcept C150903083 @default.
• W4283754016 hasConcept C170493617 @default.
• W4283754016 hasConcept C180361614 @default.
• W4283754016 hasConcept C185592680 @default.
• W4283754016 hasConcept C202751555 @default.
• W4283754016 hasConcept C203014093 @default.
• W4283754016 hasConcept C207001950 @default.
• W4283754016 hasConcept C26291073 @default.
• W4283754016 hasConcept C2775960820 @default.
• W4283754016 hasConcept C2778690821 @default.
• W4283754016 hasConcept C2780269544 @default.
• W4283754016 hasConcept C54173615 @default.
• W4283754016 hasConcept C55493867 @default.
• W4283754016 hasConcept C86803240 @default.
• W4283754016 hasConcept C89560881 @default.
• W4283754016 hasConcept C95444343 @default.
• W4283754016 hasConcept C98274493 @default.
• W4283754016 hasConceptScore W4283754016C109523444 @default.
• W4283754016 hasConceptScore W4283754016C150903083 @default.
• W4283754016 hasConceptScore W4283754016C170493617 @default.
• W4283754016 hasConceptScore W4283754016C180361614 @default.
• W4283754016 hasConceptScore W4283754016C185592680 @default.
• W4283754016 hasConceptScore W4283754016C202751555 @default.
• W4283754016 hasConceptScore W4283754016C203014093 @default.
• W4283754016 hasConceptScore W4283754016C207001950 @default.
• W4283754016 hasConceptScore W4283754016C26291073 @default.
• W4283754016 hasConceptScore W4283754016C2775960820 @default.
• W4283754016 hasConceptScore W4283754016C2778690821 @default.
• W4283754016 hasConceptScore W4283754016C2780269544 @default.
• W4283754016 hasConceptScore W4283754016C54173615 @default.
• W4283754016 hasConceptScore W4283754016C55493867 @default.
• W4283754016 hasConceptScore W4283754016C86803240 @default.
• W4283754016 hasConceptScore W4283754016C89560881 @default.
• W4283754016 hasConceptScore W4283754016C95444343 @default.
• W4283754016 hasConceptScore W4283754016C98274493 @default.
• W4283754016 hasIssue "13" @default.
• W4283754016 hasLocation W42837540161 @default.
• W4283754016 hasLocation W42837540162 @default.
• W4283754016 hasLocation W42837540163 @default.
• W4283754016 hasLocation W42837540164 @default.
• W4283754016 hasOpenAccess W4283754016 @default.
• W4283754016 hasPrimaryLocation W42837540161 @default.
• W4283754016 hasRelatedWork W2008708920 @default.

• next