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- W4283754730 startingPage "361" @default.
- W4283754730 abstract "To describe recent development of an autoantigen (GAD) treatment towards well tolerated and efficacious precision medicine in type 1 diabetes.Although subcutaneous GAD-alum treatment failed to reach primary endpoint in a phase III trial, metanalyses showed a 97% probability of efficacy, and clear efficacy in patients carrying Hyman Leucoycte Antigen (HLA) DR3DQ2. Efforts have been made to improve efficacy by trying combination therapies with vitamin D + Ibuprofen resp vitamin D + Etanercept (TNF-α inhibition), without any breakthrough until the administration of GAD-alum was changed from subcutaneous to intralymphatic. With a very small dose of GAD-alum (4 μg) given into an inguinal lymph three times with 1 month interval, the efficacy in patients with HLADR3DQ2 has been impressive, with significantly better beta cell preservation than patients who got placebo in a double-blind randomized trial, and clinical efficacy with more patients in partial remission (IDAA1c < 9) and larger proportion of patients with CGM-measured blood glucose Time In Range (TIR), significantly correlated to the C-peptide values. The treatment has been easy for patients and healthcare without treatment-related risk or adverse events.Intralymphatic GAD-alum treatment in type 1 diabetes patients carrying HLA DR3DQ2 seems to be an attractive immune intervention." @default.
- W4283754730 created "2022-07-02" @default.
- W4283754730 creator A5075567727 @default.
- W4283754730 date "2022-07-02" @default.
- W4283754730 modified "2023-09-27" @default.
- W4283754730 title "Glutamic acid decarboxylase immunotherapy for type 1 diabetes" @default.
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- W4283754730 doi "https://doi.org/10.1097/med.0000000000000748" @default.
- W4283754730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35776501" @default.
- W4283754730 hasPublicationYear "2022" @default.
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