FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283755290> ?p ?o ?g. }

• W4283755290 endingPage "7464" @default.
• W4283755290 startingPage "7451" @default.
• W4283755290 abstract "Abstract Acetaldehyde (AA), a by-product of ethanol metabolism, is acutely toxic due to its ability to react with various biological molecules including DNA and proteins, which can greatly impede key processes such as replication and transcription and lead to DNA damage. As such AA is classified as a group 1 carcinogen by the International Agency for Research on Cancer (IARC). Previous in vitro studies have shown that AA generates bulky adducts on DNA, with signature guanine-centered (GG→TT) mutations. However, due to its weak mutagenicity, short chemical half-life, and the absence of powerful genetic assays, there is considerable variability in reporting the mutagenic effects of AA in vivo. Here, we used an established yeast genetic reporter system and demonstrate that AA treatment is highly mutagenic to cells and leads to strand-biased mutations on guanines (G→T) at a high frequency on single stranded DNA (ssDNA). We further demonstrate that AA-derived mutations occur through lesion bypass on ssDNA by the translesion polymerase Polζ. Finally, we describe a unique mutation signature for AA, which we then identify in several whole-genome and -exome sequenced cancers, particularly those associated with alcohol consumption. Our study proposes a key mechanism underlying carcinogenesis by acetaldehyde—mutagenesis of single-stranded DNA." @default.
• W4283755290 created "2022-07-02" @default.
• W4283755290 creator A5041833022 @default.
• W4283755290 creator A5063124326 @default.
• W4283755290 creator A5080468216 @default.
• W4283755290 creator A5090151610 @default.
• W4283755290 date "2022-07-01" @default.
• W4283755290 modified "2023-10-18" @default.
• W4283755290 title "Acetaldehyde makes a distinct mutation signature in single-stranded DNA" @default.
• W4283755290 cites W1544906050 @default.
• W4283755290 cites W1848772619 @default.
• W4283755290 cites W1904872562 @default.
• W4283755290 cites W1974102018 @default.
• W4283755290 cites W1975989399 @default.
• W4283755290 cites W1982453626 @default.
• W4283755290 cites W1983419506 @default.
• W4283755290 cites W1988669405 @default.
• W4283755290 cites W1990884838 @default.
• W4283755290 cites W2003665515 @default.
• W4283755290 cites W2007734732 @default.
• W4283755290 cites W2013827205 @default.
• W4283755290 cites W2022684980 @default.
• W4283755290 cites W2024002114 @default.
• W4283755290 cites W2028900510 @default.
• W4283755290 cites W2031292590 @default.
• W4283755290 cites W2033893102 @default.
• W4283755290 cites W2035043537 @default.
• W4283755290 cites W2043757605 @default.
• W4283755290 cites W2046082575 @default.
• W4283755290 cites W2050503768 @default.
• W4283755290 cites W2060008831 @default.
• W4283755290 cites W2064855999 @default.
• W4283755290 cites W2077921362 @default.
• W4283755290 cites W2079218548 @default.
• W4283755290 cites W2084369408 @default.
• W4283755290 cites W2102619694 @default.
• W4283755290 cites W2103441770 @default.
• W4283755290 cites W2108871359 @default.
• W4283755290 cites W2121906867 @default.
• W4283755290 cites W2122658576 @default.
• W4283755290 cites W2124977765 @default.
• W4283755290 cites W2126958674 @default.
• W4283755290 cites W2127505174 @default.
• W4283755290 cites W2129136620 @default.
• W4283755290 cites W2130785878 @default.
• W4283755290 cites W2147963772 @default.
• W4283755290 cites W2152061559 @default.
• W4283755290 cites W2154518311 @default.
• W4283755290 cites W2157784121 @default.
• W4283755290 cites W2161815151 @default.
• W4283755290 cites W2162891049 @default.
• W4283755290 cites W2163724411 @default.
• W4283755290 cites W2167926463 @default.
• W4283755290 cites W2168494144 @default.
• W4283755290 cites W2168698826 @default.
• W4283755290 cites W2171292356 @default.
• W4283755290 cites W2204392137 @default.
• W4283755290 cites W2266041843 @default.
• W4283755290 cites W2316837928 @default.
• W4283755290 cites W2325995818 @default.
• W4283755290 cites W2526693571 @default.
• W4283755290 cites W2618031479 @default.
• W4283755290 cites W2736499558 @default.
• W4283755290 cites W2739980119 @default.
• W4283755290 cites W2752729389 @default.
• W4283755290 cites W2782652436 @default.
• W4283755290 cites W2785745834 @default.
• W4283755290 cites W2793863120 @default.
• W4283755290 cites W2913707244 @default.
• W4283755290 cites W2938255062 @default.
• W4283755290 cites W2944789892 @default.
• W4283755290 cites W3004480399 @default.
• W4283755290 cites W3006500278 @default.
• W4283755290 cites W3009094837 @default.
• W4283755290 cites W3009584281 @default.
• W4283755290 cites W3009852343 @default.
• W4283755290 cites W3045396963 @default.
• W4283755290 cites W3163560222 @default.
• W4283755290 cites W4297855254 @default.
• W4283755290 doi "https://doi.org/10.1093/nar/gkac570" @default.
• W4283755290 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35776120" @default.
• W4283755290 hasPublicationYear "2022" @default.
• W4283755290 type Work @default.
• W4283755290 citedByCount "8" @default.
• W4283755290 countsByYear W42837552902022 @default.
• W4283755290 countsByYear W42837552902023 @default.
• W4283755290 crossrefType "journal-article" @default.
• W4283755290 hasAuthorship W4283755290A5041833022 @default.
• W4283755290 hasAuthorship W4283755290A5063124326 @default.
• W4283755290 hasAuthorship W4283755290A5080468216 @default.
• W4283755290 hasAuthorship W4283755290A5090151610 @default.
• W4283755290 hasBestOaLocation W42837552901 @default.
• W4283755290 hasConcept C104317684 @default.
• W4283755290 hasConcept C134935766 @default.
• W4283755290 hasConcept C143425029 @default.
• W4283755290 hasConcept C153911025 @default.
• W4283755290 hasConcept C16318435 @default.
• W4283755290 hasConcept C2756471 @default.

• next