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- W4283757038 endingPage "104561" @default.
- W4283757038 startingPage "104561" @default.
- W4283757038 abstract "ACOD1 (also known as IRG1) has emerged as a regulator of immunometabolism that operates by producing metabolite itaconate. Here, we report a key role of STING1 (also known as STING and TMEM173) in mediating ACOD1 expression in myeloid cells in response to toll-like receptor (TLR) signaling. The activation of STING1 through exogenous cyclic dinucleotides (e.g., 3'3'-cGAMP) or endogenous gain-of-function mutation (e.g., V155M) enhances lipopolysaccharide-induced ACOD1 expression and itaconate production in macrophages and monocytes, whereas the deletion of STING1 blocks this process. The adaptor protein MYD88, instead of DNA sensor cyclic GMP-AMP synthase (CGAS), favors STING1-dependent ACOD1 expression. Mechanistically, MYD88 directly blocks autophagic degradation of STING1 and causes subsequent IRF3/JUN-mediated ACOD1 gene transcription. Consequently, the conditional deletion of STING1 in myeloid cells fails to produce ACOD1 and itaconate, thereby protecting mice against endotoxemia and polymicrobial sepsis. Our results, therefore, establish a direct link between TLR4 signaling and ACOD1 expression through the STING1-MYD88 complex during septic shock." @default.
- W4283757038 created "2022-07-02" @default.
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- W4283757038 creator A5055468442 @default.
- W4283757038 creator A5091664811 @default.
- W4283757038 date "2022-07-01" @default.
- W4283757038 modified "2023-10-16" @default.
- W4283757038 title "The STING1-MYD88 complex drives ACOD1/IRG1 expression and function in lethal innate immunity" @default.
- W4283757038 cites W1966408457 @default.
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- W4283757038 cites W1975556592 @default.
- W4283757038 cites W1994190235 @default.
- W4283757038 cites W1994691573 @default.
- W4283757038 cites W2004465286 @default.
- W4283757038 cites W2011103030 @default.
- W4283757038 cites W2015310325 @default.
- W4283757038 cites W2016131266 @default.
- W4283757038 cites W2031182394 @default.
- W4283757038 cites W2060004514 @default.
- W4283757038 cites W2066818317 @default.
- W4283757038 cites W2068619092 @default.
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- W4283757038 cites W2093139840 @default.
- W4283757038 cites W2114242405 @default.
- W4283757038 cites W2129319296 @default.
- W4283757038 cites W2139936109 @default.
- W4283757038 cites W2158738222 @default.
- W4283757038 cites W2164714222 @default.
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- W4283757038 cites W2165748936 @default.
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- W4283757038 cites W2797967513 @default.
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- W4283757038 cites W3016406540 @default.
- W4283757038 cites W3023051922 @default.
- W4283757038 cites W3026959467 @default.
- W4283757038 cites W3037861729 @default.
- W4283757038 cites W3044531785 @default.
- W4283757038 cites W3048446878 @default.
- W4283757038 cites W3093435904 @default.
- W4283757038 cites W3096653119 @default.
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- W4283757038 doi "https://doi.org/10.1016/j.isci.2022.104561" @default.
- W4283757038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35769880" @default.
- W4283757038 hasPublicationYear "2022" @default.
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