Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283760147> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W4283760147 endingPage "490" @default.
- W4283760147 startingPage "481" @default.
- W4283760147 abstract "The last 50 years have experienced a rapid evolution in the development of lipid-lowering agents to reduce low-density lipoprotein cholesterol levels. This significant advance in medicine has not occurred without debate. Whether lowering blood cholesterol levels was beneficial has remained one of the most controversial issues during the past 50 years. The discovery of statins was the revolution that made it possible to delay and stop the progression of the atherosclerotic process resulting in improved health and longevity for millions of people. To date, statins remain the drugs of choice for the treatment of hypercholesterolemia. Despite their use, the risk of cardiovascular events persists. Therefore, the use of non-statin drugs, such as ezetimibe or PCSK9 inhibitors, in combination with statins has been shown to further reduce the risk of cardiovascular events. This review aims to summarize the advances in the field of lipid-lowering therapies over the past 50 years, focusing on advances in the development of drug therapies up to and including gene silencing or gene editing treatments that are expected in the near future." @default.
- W4283760147 created "2022-07-02" @default.
- W4283760147 creator A5000200390 @default.
- W4283760147 creator A5004895617 @default.
- W4283760147 creator A5055478790 @default.
- W4283760147 creator A5068281952 @default.
- W4283760147 creator A5087924459 @default.
- W4283760147 date "2022-07-01" @default.
- W4283760147 modified "2023-10-14" @default.
- W4283760147 title "[From statin revolution to gene silencing therapy: 50 years of evolution in the treatment of hypercholesterolemia]." @default.
- W4283760147 doi "https://doi.org/10.1714/3831.38165" @default.
- W4283760147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35771013" @default.
- W4283760147 hasPublicationYear "2022" @default.
- W4283760147 type Work @default.
- W4283760147 citedByCount "1" @default.
- W4283760147 countsByYear W42837601472023 @default.
- W4283760147 crossrefType "journal-article" @default.
- W4283760147 hasAuthorship W4283760147A5000200390 @default.
- W4283760147 hasAuthorship W4283760147A5004895617 @default.
- W4283760147 hasAuthorship W4283760147A5055478790 @default.
- W4283760147 hasAuthorship W4283760147A5068281952 @default.
- W4283760147 hasAuthorship W4283760147A5087924459 @default.
- W4283760147 hasConcept C104317684 @default.
- W4283760147 hasConcept C119056186 @default.
- W4283760147 hasConcept C126322002 @default.
- W4283760147 hasConcept C177713679 @default.
- W4283760147 hasConcept C2776839432 @default.
- W4283760147 hasConcept C2778657065 @default.
- W4283760147 hasConcept C54355233 @default.
- W4283760147 hasConcept C60644358 @default.
- W4283760147 hasConcept C71924100 @default.
- W4283760147 hasConcept C86803240 @default.
- W4283760147 hasConcept C98274493 @default.
- W4283760147 hasConceptScore W4283760147C104317684 @default.
- W4283760147 hasConceptScore W4283760147C119056186 @default.
- W4283760147 hasConceptScore W4283760147C126322002 @default.
- W4283760147 hasConceptScore W4283760147C177713679 @default.
- W4283760147 hasConceptScore W4283760147C2776839432 @default.
- W4283760147 hasConceptScore W4283760147C2778657065 @default.
- W4283760147 hasConceptScore W4283760147C54355233 @default.
- W4283760147 hasConceptScore W4283760147C60644358 @default.
- W4283760147 hasConceptScore W4283760147C71924100 @default.
- W4283760147 hasConceptScore W4283760147C86803240 @default.
- W4283760147 hasConceptScore W4283760147C98274493 @default.
- W4283760147 hasIssue "7" @default.
- W4283760147 hasLocation W42837601471 @default.
- W4283760147 hasOpenAccess W4283760147 @default.
- W4283760147 hasPrimaryLocation W42837601471 @default.
- W4283760147 hasRelatedWork W10460107 @default.
- W4283760147 hasRelatedWork W11941710 @default.
- W4283760147 hasRelatedWork W1394974 @default.
- W4283760147 hasRelatedWork W18589541 @default.
- W4283760147 hasRelatedWork W1921770 @default.
- W4283760147 hasRelatedWork W20153909 @default.
- W4283760147 hasRelatedWork W3033428 @default.
- W4283760147 hasRelatedWork W4006971 @default.
- W4283760147 hasRelatedWork W5036666 @default.
- W4283760147 hasRelatedWork W5949843 @default.
- W4283760147 hasVolume "23" @default.
- W4283760147 isParatext "false" @default.
- W4283760147 isRetracted "false" @default.
- W4283760147 workType "article" @default.