FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283764180> ?p ?o ?g. }

• W4283764180 abstract "Colorectal cancer (CRC) is characterized by early metastasis, resistance to anti-cancer therapy, and high mortality rate. Despite considerable progress in the development of new treatment options that improved survival benefits in patients with early-stage or advanced CRC, many patients relapse due to the activation of intrinsic or acquired chemoresistance mechanisms. Recently, we reported novel findings about the role of Jagged1 in CRC tumors with Kras signatures. We showed that Jagged1 is a novel proteolytic target of Kras signaling, which induces Jagged1 processing/activation resulting in Jag1-ICD release, which favors tumor development in vivo, through a non-canonical mechanism. Herein, we demonstrate that OXP and 5FU cause a strong accumulation of Jag1-ICD oncogene, through ERK1/2 activation, unveiling a surviving subpopulation with an enforced Jag1-ICD expression, presenting the ability to counteract OXP/5FU-induced apoptosis. Remarkably, we also clarify the clinical ineffectiveness of γ-secretase inhibitors (GSIs) in metastatic CRC (mCRC) patients. Indeed, we show that GSI compounds trigger Jag1-ICD release, which promotes cellular growth and EMT processes, functioning as tumor-promoting agents in CRC cells overexpressing Jagged1. We finally demonstrate that Jagged1 silencing in OXP- or 5FU-resistant subpopulations is enough to restore the sensitivity to chemotherapy, confirming that drug sensitivity/resistance is Jag1-ICD-dependent, suggesting Jagged1 as a molecular predictive marker for the outcome of chemotherapy." @default.
• W4283764180 created "2022-07-02" @default.
• W4283764180 creator A5012308260 @default.
• W4283764180 creator A5013094061 @default.
• W4283764180 creator A5013703740 @default.
• W4283764180 creator A5013727905 @default.
• W4283764180 creator A5015680218 @default.
• W4283764180 creator A5035053804 @default.
• W4283764180 creator A5038130714 @default.
• W4283764180 creator A5039432271 @default.
• W4283764180 creator A5047735457 @default.
• W4283764180 creator A5065676249 @default.
• W4283764180 creator A5068216029 @default.
• W4283764180 date "2022-07-01" @default.
• W4283764180 modified "2023-09-26" @default.
• W4283764180 title "5FU/Oxaliplatin-Induced Jagged1 Cleavage Counteracts Apoptosis Induction in Colorectal Cancer: A Novel Mechanism of Intrinsic Drug Resistance" @default.
• W4283764180 cites W1538208486 @default.
• W4283764180 cites W1983708448 @default.
• W4283764180 cites W2007431130 @default.
• W4283764180 cites W2007514087 @default.
• W4283764180 cites W2017926292 @default.
• W4283764180 cites W2047312475 @default.
• W4283764180 cites W2051225015 @default.
• W4283764180 cites W2062150443 @default.
• W4283764180 cites W2081360195 @default.
• W4283764180 cites W2090718507 @default.
• W4283764180 cites W2094328127 @default.
• W4283764180 cites W2113672344 @default.
• W4283764180 cites W2121368761 @default.
• W4283764180 cites W2125210959 @default.
• W4283764180 cites W2128447158 @default.
• W4283764180 cites W2130177169 @default.
• W4283764180 cites W2135201496 @default.
• W4283764180 cites W2140843725 @default.
• W4283764180 cites W2141665958 @default.
• W4283764180 cites W2143234817 @default.
• W4283764180 cites W2158910681 @default.
• W4283764180 cites W2168833693 @default.
• W4283764180 cites W2221837786 @default.
• W4283764180 cites W2239414584 @default.
• W4283764180 cites W2417978719 @default.
• W4283764180 cites W2565226894 @default.
• W4283764180 cites W2591370630 @default.
• W4283764180 cites W2611295065 @default.
• W4283764180 cites W2734805760 @default.
• W4283764180 cites W2736866570 @default.
• W4283764180 cites W2792088665 @default.
• W4283764180 cites W2803370004 @default.
• W4283764180 cites W2903204123 @default.
• W4283764180 cites W2925631060 @default.
• W4283764180 cites W2972637542 @default.
• W4283764180 cites W3011481749 @default.
• W4283764180 cites W3092885446 @default.
• W4283764180 cites W3150482294 @default.
• W4283764180 doi "https://doi.org/10.3389/fonc.2022.918763" @default.
• W4283764180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35847908" @default.
• W4283764180 hasPublicationYear "2022" @default.
• W4283764180 type Work @default.
• W4283764180 citedByCount "0" @default.
• W4283764180 crossrefType "journal-article" @default.
• W4283764180 hasAuthorship W4283764180A5012308260 @default.
• W4283764180 hasAuthorship W4283764180A5013094061 @default.
• W4283764180 hasAuthorship W4283764180A5013703740 @default.
• W4283764180 hasAuthorship W4283764180A5013727905 @default.
• W4283764180 hasAuthorship W4283764180A5015680218 @default.
• W4283764180 hasAuthorship W4283764180A5035053804 @default.
• W4283764180 hasAuthorship W4283764180A5038130714 @default.
• W4283764180 hasAuthorship W4283764180A5039432271 @default.
• W4283764180 hasAuthorship W4283764180A5047735457 @default.
• W4283764180 hasAuthorship W4283764180A5065676249 @default.
• W4283764180 hasAuthorship W4283764180A5068216029 @default.
• W4283764180 hasBestOaLocation W42837641801 @default.
• W4283764180 hasConcept C104317684 @default.
• W4283764180 hasConcept C119056186 @default.
• W4283764180 hasConcept C121608353 @default.
• W4283764180 hasConcept C126322002 @default.
• W4283764180 hasConcept C161879069 @default.
• W4283764180 hasConcept C170493617 @default.
• W4283764180 hasConcept C190283241 @default.
• W4283764180 hasConcept C2776694085 @default.
• W4283764180 hasConcept C2778668844 @default.
• W4283764180 hasConcept C2779013556 @default.
• W4283764180 hasConcept C2780962732 @default.
• W4283764180 hasConcept C2781187634 @default.
• W4283764180 hasConcept C502942594 @default.
• W4283764180 hasConcept C526805850 @default.
• W4283764180 hasConcept C55493867 @default.
• W4283764180 hasConcept C71924100 @default.
• W4283764180 hasConcept C86803240 @default.
• W4283764180 hasConceptScore W4283764180C104317684 @default.
• W4283764180 hasConceptScore W4283764180C119056186 @default.
• W4283764180 hasConceptScore W4283764180C121608353 @default.
• W4283764180 hasConceptScore W4283764180C126322002 @default.
• W4283764180 hasConceptScore W4283764180C161879069 @default.
• W4283764180 hasConceptScore W4283764180C170493617 @default.
• W4283764180 hasConceptScore W4283764180C190283241 @default.
• W4283764180 hasConceptScore W4283764180C2776694085 @default.
• W4283764180 hasConceptScore W4283764180C2778668844 @default.
• W4283764180 hasConceptScore W4283764180C2779013556 @default.
• W4283764180 hasConceptScore W4283764180C2780962732 @default.

• next