FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283764458> ?p ?o ?g. }

• W4283764458 endingPage "16" @default.
• W4283764458 startingPage "1" @default.
• W4283764458 abstract "Acute myocardial ischemia (AMI) is a condition caused by a decrease in blood flow to the heart that can sometimes predispose to acquired long QT syndrome (LQTS), thereby resulting in sudden cardiac death. Recent evidence indicates that electroacupuncture (EA) can alleviate MI injury, but its specific mechanism remains unclear. This study was aimed at investigating the efficacy of EA, which utilizes α1A-adrenergic receptors (α1A-AR) in alleviating MI injury as well as the resulting LQTS. The AMI model was established by ligating the left anterior descending arteries (LAD) of both the wild-type and α1A gene-knockout mice and treating them with EA for three consecutive days. A PowerLab 16 physiological recorder was used to collect the electrocardiogram (ECG) while the serum creatine kinase isoenzymes (CK-MB), lactate dehydrogenase (LDH), and norepinephrine (NE) levels in myocardial tissue were determined by using the enzyme-linked immunosorbent assay (ELISA) kit. Moreover, TTC staining was used to observe the myocardial ischemic area, while H&E and TUNEL staining determined the pathological morphology of the myocardium. Quantitative real-time PCR (qRT-PCR) was used to detect the α1A mRNA, and Western blot was used to detect the specific proteins, such as α1A, cleaved caspase-3, Gq, PLC, p-PKCα, and p-hERG. Our results showed that EA could effectively reduce elevated ST-segment, shorten the extended QT interval, and reduce the serum myocardial enzyme content and the degree of pathological injury in wild mice with MI. EA can also decrease the expression of α1A-AR, PLC, p-PKCα, and NE content in myocardial tissues of wild mice, while those of p-hERG increased in ischemic myocardial tissue. These findings suggested that α1A-AR is involved in the development of MI as well as LQTS. Additionally, EA treatment improves the cardiac function and ischemic long QT interval and plays an important role in reducing the hERG inhibition through the α1A-AR-mediated Gq/PLC/PKCα pathway and myocardial apoptosis. Hence, it is suggested that α1A-AR might become a potential target for EA in treating AMI treatment of myocardial ischemia injury and acquired long QT intervals caused by MI." @default.
• W4283764458 created "2022-07-02" @default.
• W4283764458 creator A5013478795 @default.
• W4283764458 creator A5015100484 @default.
• W4283764458 creator A5026170167 @default.
• W4283764458 creator A5051086805 @default.
• W4283764458 creator A5059702655 @default.
• W4283764458 creator A5081868806 @default.
• W4283764458 creator A5083027530 @default.
• W4283764458 creator A5085067672 @default.
• W4283764458 creator A5089360021 @default.
• W4283764458 date "2022-06-30" @default.
• W4283764458 modified "2023-10-14" @default.
• W4283764458 title "Electroacupuncture Ameliorates Acute Myocardial Ischemic Injury and Long QT Interval in Mice through the α1A-Adrenergic Receptor: Electrophysiological, Morphological, and Molecular Evidence" @default.
• W4283764458 cites W1544396097 @default.
• W4283764458 cites W1966659841 @default.
• W4283764458 cites W1967525035 @default.
• W4283764458 cites W1975540310 @default.
• W4283764458 cites W1979417953 @default.
• W4283764458 cites W1980249371 @default.
• W4283764458 cites W1984741559 @default.
• W4283764458 cites W1993401259 @default.
• W4283764458 cites W1993828897 @default.
• W4283764458 cites W1995527760 @default.
• W4283764458 cites W2038996373 @default.
• W4283764458 cites W2048994896 @default.
• W4283764458 cites W2061463522 @default.
• W4283764458 cites W2073902635 @default.
• W4283764458 cites W2077562802 @default.
• W4283764458 cites W2078338402 @default.
• W4283764458 cites W2080867320 @default.
• W4283764458 cites W2090058377 @default.
• W4283764458 cites W2095440004 @default.
• W4283764458 cites W2112823717 @default.
• W4283764458 cites W2123679070 @default.
• W4283764458 cites W2132267388 @default.
• W4283764458 cites W2146037149 @default.
• W4283764458 cites W2169880599 @default.
• W4283764458 cites W2190372945 @default.
• W4283764458 cites W2227236903 @default.
• W4283764458 cites W2461822751 @default.
• W4283764458 cites W2496445900 @default.
• W4283764458 cites W2503732928 @default.
• W4283764458 cites W2548502736 @default.
• W4283764458 cites W2548844238 @default.
• W4283764458 cites W2562742081 @default.
• W4283764458 cites W2612637790 @default.
• W4283764458 cites W2745072699 @default.
• W4283764458 cites W2751405380 @default.
• W4283764458 cites W2759364043 @default.
• W4283764458 cites W2763468619 @default.
• W4283764458 cites W2772221195 @default.
• W4283764458 cites W2781991992 @default.
• W4283764458 cites W2792266541 @default.
• W4283764458 cites W2795188112 @default.
• W4283764458 cites W2809600798 @default.
• W4283764458 cites W2897399130 @default.
• W4283764458 cites W2907162817 @default.
• W4283764458 cites W2909188869 @default.
• W4283764458 cites W2953282350 @default.
• W4283764458 cites W2963749827 @default.
• W4283764458 cites W2965483652 @default.
• W4283764458 cites W2968104010 @default.
• W4283764458 cites W2969623738 @default.
• W4283764458 cites W2970447141 @default.
• W4283764458 cites W2995626362 @default.
• W4283764458 cites W2996791939 @default.
• W4283764458 cites W3000172297 @default.
• W4283764458 cites W3003639774 @default.
• W4283764458 cites W3014613440 @default.
• W4283764458 cites W3020395659 @default.
• W4283764458 cites W3112056065 @default.
• W4283764458 cites W3156393561 @default.
• W4283764458 cites W3200404475 @default.
• W4283764458 doi "https://doi.org/10.1155/2022/1984706" @default.
• W4283764458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35814274" @default.
• W4283764458 hasPublicationYear "2022" @default.
• W4283764458 type Work @default.
• W4283764458 citedByCount "0" @default.
• W4283764458 crossrefType "journal-article" @default.
• W4283764458 hasAuthorship W4283764458A5013478795 @default.
• W4283764458 hasAuthorship W4283764458A5015100484 @default.
• W4283764458 hasAuthorship W4283764458A5026170167 @default.
• W4283764458 hasAuthorship W4283764458A5051086805 @default.
• W4283764458 hasAuthorship W4283764458A5059702655 @default.
• W4283764458 hasAuthorship W4283764458A5081868806 @default.
• W4283764458 hasAuthorship W4283764458A5083027530 @default.
• W4283764458 hasAuthorship W4283764458A5085067672 @default.
• W4283764458 hasAuthorship W4283764458A5089360021 @default.
• W4283764458 hasBestOaLocation W42837644581 @default.
• W4283764458 hasConcept C118441451 @default.
• W4283764458 hasConcept C126322002 @default.
• W4283764458 hasConcept C134018914 @default.
• W4283764458 hasConcept C158453852 @default.
• W4283764458 hasConcept C164705383 @default.
• W4283764458 hasConcept C170493617 @default.
• W4283764458 hasConcept C181199279 @default.
• W4283764458 hasConcept C2775935837 @default.

• next