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- W4283766044 abstract "Dermal papilla cells (DPCs) are an important element of the hair follicle (HF) niche, widely used as an in vitro model to study hair growth-related research. These cells are usually grown in 2D culture, but this system did not show efficient therapeutic effects on HF regeneration and growth, and key differences were observed between cell activity in vitro and in vivo. Recent studies have showed that DPCs grown in 3D hanging spheroids are more morphologically akin to an intact DP microenvironment. In this current study, global gene molecular analysis showed that the 3D model highly affected cell adhesion molecules and hair growth-related pathways. Furthermore, we compared the expression of signalling molecules and metabolism-associated proteins of DPCs treated with minoxidil (an FDA-approved drug for hair loss treatment) and 3,4,5-tri-O-caffeoylquinic acid (TCQA) (recently found to induce hair growth in vitro and in vivo) in 3D spheroid hanging drops and a 2D monolayer using DNA microarray analysis. Further validations by determining the gene and protein expressions of key signature molecules showed the suitability of this 3D system for enhancing the DPC activity of the hair growth-promoting agents minoxidil and TCQA." @default.
- W4283766044 created "2022-07-02" @default.
- W4283766044 creator A5031870381 @default.
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- W4283766044 creator A5068111629 @default.
- W4283766044 creator A5078891793 @default.
- W4283766044 creator A5086514346 @default.
- W4283766044 date "2022-06-30" @default.
- W4283766044 modified "2023-09-26" @default.
- W4283766044 title "3D Spheroid Human Dermal Papilla Cell as an Effective Model for the Screening of Hair Growth Promoting Compounds: Examples of Minoxidil and 3,4,5-Tri-O-caffeoylquinic acid (TCQA)" @default.
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- W4283766044 doi "https://doi.org/10.3390/cells11132093" @default.
- W4283766044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35805177" @default.
- W4283766044 hasPublicationYear "2022" @default.
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