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- W4283767552 abstract "Systemic chemotherapy is the mainstay of treatment of pancreatic adenocarcinoma (PAC). Evaluating therapeutic response is essential to achieve the maximum possible benefit. We aimed to investigate the role of tissue- and blood -based biomarkers in their feasibility to predict the effect of chemotherapy in PAC patients. Between April 2019 and December 2020, a total of 238 patients were sequentially enrolled in this prospective cohort study. Among them, 112 (47%) had metastatic or recurrent PAC. Tumor tissue expression of hENT1, DCK, CES2, and SMAD4 were evaluated by immunohistochemistry, which biomarkers were reported to predict the response to gemcitabine or FOLFIRINOX chemotherapies. Germline BRCA mutations and MSI status were also tested. The concentration and fraction of KRAS mutations were determined through multiplex detection of KRAS mutations in plasma samples by use of a droplet digital PCR kit (Bio-Rad). One hundred thirty patients were received FOLFIRINOX as first-line chemotherapy, while 58 patients were treated with gemcitabine-based chemotherapy. Progression-free survival and overall survival were compared according to marker expression. There is no significant association between tissue expressions of hENT1, DCK, CES2, and SMAD4 and survival outcomes. Higher mutant KRAS concentration was significantly associated with poorer progression-free survival (HR 2.72, 95% CI 1.53-4.82; P < 0.001) and overall survival (HR 2.73, 95% CI 1.36-5.47; P < 0.01) in patient who received FOLFIRINOX. There was no predictive effect of mutant KRAS concentration in patient with gemcitabine-based chemotherapy. The preliminary results suggest that high pre-treatment KRAS mutation was associated with a negative impact on survival in patients with FOLFIRINOX. Further investigations are warranted." @default.
- W4283767552 created "2022-07-03" @default.
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- W4283767552 date "2022-06-01" @default.
- W4283767552 modified "2023-09-29" @default.
- W4283767552 title "P-196 Circulating tumor DNA as a prognostic biomarker in pancreatic cancer patients treated with FOLFIRINOX: A prospective cohort study" @default.
- W4283767552 doi "https://doi.org/10.1016/j.annonc.2022.04.286" @default.
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