Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283767945> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W4283767945 endingPage "191" @default.
- W4283767945 startingPage "177" @default.
- W4283767945 abstract "Epilepsy is a common neurological disorder that affects around 70 million people in the world, which represents approximately 1%of the world population. Seizures are transitory episodes produced by excessive neuronal discharges. They are characterized bytransient behavioral changes that are caused by abnormal and excessive neuronal synchronization in the brain. These episodes canbe triggered by genetic or acquired factors that alter normal brain function such as autoimmune diseases, genetic mutations,encephalopathies, head trauma, cerebrovascular accidents, febrile seizures or statusepilepticus. Temporal lobe epilepsy is a seriousneurological disorder, which represents 60% to 70% of drug-resistant epilepsy, and is an important form of epilepsy acquired byany of the factors mentioned. Seizures can generate recurrent cycles of excitotoxicity and oxidative stress that cause neuronaldamage and cell death. Oxidative stress is an imbalance between the endogenous antioxidant system and the overproduction ofreactive oxygen species (ROS), consequently, oxidation of proteins, lipids and nucleic acids occurs in the brain, resulting inapoptosis, proteopathies, mitochondrial dysfunction, glial cell activation and neuroinflammation. ROS are responsible for thegeneration of oxidative stress and could be involved in neuronal damage that contributes to the establishment of epileptogenesis andspontaneous seizures in patients and experimental models. The administration of agents with antioxidant and anti-inflammatoryproperties could represent a therapeutic alternative aimed at reducing oxidative stress during epileptogenesis or seizures to reducethe severity of the pathological processes involved, and thus attenuate the neurobiological consequences that occur in temporal lobeepilepsy." @default.
- W4283767945 created "2022-07-03" @default.
- W4283767945 creator A5063764162 @default.
- W4283767945 creator A5065651854 @default.
- W4283767945 creator A5090330010 @default.
- W4283767945 date "2022-04-26" @default.
- W4283767945 modified "2023-10-14" @default.
- W4283767945 title "Efecto de los antioxidantes en la epilepsia del lóbulo temporal" @default.
- W4283767945 doi "https://doi.org/10.32870/ecucba.vi18.252" @default.
- W4283767945 hasPublicationYear "2022" @default.
- W4283767945 type Work @default.
- W4283767945 citedByCount "0" @default.
- W4283767945 crossrefType "journal-article" @default.
- W4283767945 hasAuthorship W4283767945A5063764162 @default.
- W4283767945 hasAuthorship W4283767945A5065651854 @default.
- W4283767945 hasAuthorship W4283767945A5090330010 @default.
- W4283767945 hasBestOaLocation W42837679451 @default.
- W4283767945 hasConcept C126322002 @default.
- W4283767945 hasConcept C15744967 @default.
- W4283767945 hasConcept C169760540 @default.
- W4283767945 hasConcept C170493617 @default.
- W4283767945 hasConcept C25498285 @default.
- W4283767945 hasConcept C2776151105 @default.
- W4283767945 hasConcept C2777341932 @default.
- W4283767945 hasConcept C2778186239 @default.
- W4283767945 hasConcept C2781012912 @default.
- W4283767945 hasConcept C2908647359 @default.
- W4283767945 hasConcept C57236427 @default.
- W4283767945 hasConcept C61174792 @default.
- W4283767945 hasConcept C71924100 @default.
- W4283767945 hasConcept C99454951 @default.
- W4283767945 hasConceptScore W4283767945C126322002 @default.
- W4283767945 hasConceptScore W4283767945C15744967 @default.
- W4283767945 hasConceptScore W4283767945C169760540 @default.
- W4283767945 hasConceptScore W4283767945C170493617 @default.
- W4283767945 hasConceptScore W4283767945C25498285 @default.
- W4283767945 hasConceptScore W4283767945C2776151105 @default.
- W4283767945 hasConceptScore W4283767945C2777341932 @default.
- W4283767945 hasConceptScore W4283767945C2778186239 @default.
- W4283767945 hasConceptScore W4283767945C2781012912 @default.
- W4283767945 hasConceptScore W4283767945C2908647359 @default.
- W4283767945 hasConceptScore W4283767945C57236427 @default.
- W4283767945 hasConceptScore W4283767945C61174792 @default.
- W4283767945 hasConceptScore W4283767945C71924100 @default.
- W4283767945 hasConceptScore W4283767945C99454951 @default.
- W4283767945 hasIssue "18" @default.
- W4283767945 hasLocation W42837679451 @default.
- W4283767945 hasOpenAccess W4283767945 @default.
- W4283767945 hasPrimaryLocation W42837679451 @default.
- W4283767945 hasRelatedWork W1125507816 @default.
- W4283767945 hasRelatedWork W1969430202 @default.
- W4283767945 hasRelatedWork W1994308963 @default.
- W4283767945 hasRelatedWork W2010549246 @default.
- W4283767945 hasRelatedWork W2040244997 @default.
- W4283767945 hasRelatedWork W2063228636 @default.
- W4283767945 hasRelatedWork W2077302930 @default.
- W4283767945 hasRelatedWork W2162771767 @default.
- W4283767945 hasRelatedWork W2409759976 @default.
- W4283767945 hasRelatedWork W77394603 @default.
- W4283767945 hasVolume "9" @default.
- W4283767945 isParatext "false" @default.
- W4283767945 isRetracted "false" @default.
- W4283767945 workType "article" @default.