Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283768093> ?p ?o ?g. }
- W4283768093 abstract "Copper is a critical regulator of plant growth and development. However, the mechanisms by which copper responds to virus invasion are unclear. We previously showed that SPL9-mediated transcriptional activation of miR528 adds a previously unidentified regulatory layer to the established ARGONAUTE (AGO18)-miR528-L-ascorbate oxidase (AO) antiviral defense. Here, we report that rice promotes copper accumulation in shoots by inducing copper transporter genes, including HMA5 and COPT, to counteract viral infection. Copper suppresses the transcriptional activation of miR528 by inhibiting the protein level of SPL9, thus alleviating miR528-mediated cleavage of AO transcripts to strengthen the antiviral response. Loss-of-function mutations in HMA5, COPT1, and COPT5 caused a significant reduction in copper accumulation and plant viral resistance because of the increased SPL9-mediated miR528 transcription. Gain in viral susceptibility was mitigated when SPL9 was mutated in the hma5 mutant background. Our study elucidates the molecular mechanisms and regulatory networks of copper homeostasis and the SPL9-miR528-AO antiviral pathway." @default.
- W4283768093 created "2022-07-03" @default.
- W4283768093 creator A5033658593 @default.
- W4283768093 creator A5039614239 @default.
- W4283768093 creator A5053497577 @default.
- W4283768093 creator A5054459491 @default.
- W4283768093 creator A5055525587 @default.
- W4283768093 creator A5058591736 @default.
- W4283768093 creator A5074687519 @default.
- W4283768093 creator A5079667853 @default.
- W4283768093 creator A5081451867 @default.
- W4283768093 creator A5082540861 @default.
- W4283768093 creator A5088082429 @default.
- W4283768093 date "2022-07-01" @default.
- W4283768093 modified "2023-10-16" @default.
- W4283768093 title "The key micronutrient copper orchestrates broad-spectrum virus resistance in rice" @default.
- W4283768093 cites W1201157366 @default.
- W4283768093 cites W1553898020 @default.
- W4283768093 cites W1985685584 @default.
- W4283768093 cites W1988549734 @default.
- W4283768093 cites W1990492842 @default.
- W4283768093 cites W2004772940 @default.
- W4283768093 cites W2009071581 @default.
- W4283768093 cites W2057847071 @default.
- W4283768093 cites W2088149687 @default.
- W4283768093 cites W2091001899 @default.
- W4283768093 cites W2098169788 @default.
- W4283768093 cites W2099540110 @default.
- W4283768093 cites W2100224754 @default.
- W4283768093 cites W2100750955 @default.
- W4283768093 cites W2118159036 @default.
- W4283768093 cites W2124163020 @default.
- W4283768093 cites W2125037450 @default.
- W4283768093 cites W2128171377 @default.
- W4283768093 cites W2129740389 @default.
- W4283768093 cites W2139954188 @default.
- W4283768093 cites W2146355571 @default.
- W4283768093 cites W2149996760 @default.
- W4283768093 cites W2151284271 @default.
- W4283768093 cites W2155973543 @default.
- W4283768093 cites W2161205514 @default.
- W4283768093 cites W2162515800 @default.
- W4283768093 cites W2165445397 @default.
- W4283768093 cites W2166211878 @default.
- W4283768093 cites W2279087517 @default.
- W4283768093 cites W2510765724 @default.
- W4283768093 cites W2538671407 @default.
- W4283768093 cites W2568472318 @default.
- W4283768093 cites W2755926329 @default.
- W4283768093 cites W2761186049 @default.
- W4283768093 cites W2767422184 @default.
- W4283768093 cites W2774863101 @default.
- W4283768093 cites W2777036343 @default.
- W4283768093 cites W2796171951 @default.
- W4283768093 cites W2803645366 @default.
- W4283768093 cites W2805389654 @default.
- W4283768093 cites W2892143110 @default.
- W4283768093 cites W2895829909 @default.
- W4283768093 cites W2914597028 @default.
- W4283768093 cites W2942984823 @default.
- W4283768093 cites W2943688198 @default.
- W4283768093 cites W2944642790 @default.
- W4283768093 cites W2997864947 @default.
- W4283768093 cites W3014578986 @default.
- W4283768093 cites W3027771447 @default.
- W4283768093 cites W3033619531 @default.
- W4283768093 cites W3036118684 @default.
- W4283768093 cites W3046808342 @default.
- W4283768093 cites W3082424113 @default.
- W4283768093 cites W3108369632 @default.
- W4283768093 cites W3109865286 @default.
- W4283768093 cites W3126611528 @default.
- W4283768093 cites W3129128116 @default.
- W4283768093 cites W3131823142 @default.
- W4283768093 cites W3165655619 @default.
- W4283768093 cites W3165676933 @default.
- W4283768093 cites W4237902408 @default.
- W4283768093 doi "https://doi.org/10.1126/sciadv.abm0660" @default.
- W4283768093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35776788" @default.
- W4283768093 hasPublicationYear "2022" @default.
- W4283768093 type Work @default.
- W4283768093 citedByCount "9" @default.
- W4283768093 countsByYear W42837680932022 @default.
- W4283768093 countsByYear W42837680932023 @default.
- W4283768093 crossrefType "journal-article" @default.
- W4283768093 hasAuthorship W4283768093A5033658593 @default.
- W4283768093 hasAuthorship W4283768093A5039614239 @default.
- W4283768093 hasAuthorship W4283768093A5053497577 @default.
- W4283768093 hasAuthorship W4283768093A5054459491 @default.
- W4283768093 hasAuthorship W4283768093A5055525587 @default.
- W4283768093 hasAuthorship W4283768093A5058591736 @default.
- W4283768093 hasAuthorship W4283768093A5074687519 @default.
- W4283768093 hasAuthorship W4283768093A5079667853 @default.
- W4283768093 hasAuthorship W4283768093A5081451867 @default.
- W4283768093 hasAuthorship W4283768093A5082540861 @default.
- W4283768093 hasAuthorship W4283768093A5088082429 @default.
- W4283768093 hasConcept C104317684 @default.
- W4283768093 hasConcept C138885662 @default.
- W4283768093 hasConcept C143065580 @default.
- W4283768093 hasConcept C14522933 @default.