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- W4283769868 abstract "We aimed to demonstrate the effects circ_0058063 exerted on oral squamous cell carcinoma (OSCC) and its downstream mechanism associated with miR-145-5p and SERPINE1.The relevant contents of miR-145-5p, circ 0058063, and SERPINE1 mRNAs in OSCC were evaluated using quantitative reverse transcription polymerase chain reaction. Functional experiments including CCK-8, Transwell, Western blot, and in vivo experiment were implemented to investigate the biological impacts on OSCC cells. Using dual-luciferase reporter, RIP, and RNA pull-down assays, the direct binding relationship between miR-145-5p, circ 0058063, and SERPINE1, SMAD3, CYR61, and IGF1R mRNAs was verified.In OSCC, Circ 0058063 was significantly overexpressed. Knockdown of circ_0058063 suppressed OSCC cell migration and proliferation, but enhanced cell apoptosis. Functionally and mechanistically, circ_0058063 could specifically bind with miR-145-5p and thus upregulated expression of downstream target SERPINE1, which together contributed to the progression of OSCC.Circ_0058063 could promote the malignant behavior of OSCC by upregulating SERPINE1 through sponging miR-145-5p." @default.
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- W4283769868 date "2022-08-01" @default.
- W4283769868 modified "2023-09-29" @default.
- W4283769868 title "Circ_0058063 contributes to oral squamous cell carcinoma development by sponging miR‐145‐5p and upregulating SERPINE1" @default.
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- W4283769868 doi "https://doi.org/10.1111/jop.13331" @default.
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