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- W4283771079 abstract "Les statines constituent la pierre angulaire dans la prévention primaire et secondaire des maladies cardio-vasculaires. Toutefois, des variations interindividuelles en termes d’efficacité et de tolérance ont été observées. Bien que plusieurs polymorphismes impactant la pharmacologie des statines aient été identifiés, seuls ceux qui affectent leur transporteur Organic Anion Transporting Polypeptide family member 1B1 font l’objet de recommandations basées sur le génotype afin d’optimiser l’efficacité tout en réduisant la prévalence de la myotoxicité. Statins are the cornerstone in the primary and secondary prevention of cardiovascular disease. However, inter-individual variations in efficacy and safety have been observed. Although several polymorphisms impacting statin pharmacology have been identified, only those affecting their Organic Anion Transporting Polypeptide family member 1B1 are subject to genotype-based recommendations to optimize efficacy while reducing the prevalence of myotoxicity." @default.
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- W4283771079 date "2022-05-01" @default.
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- W4283771079 title "Apport de la pharmacogénétique dans le domaine cardio-vasculaire, l’exemple des statines" @default.
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- W4283771079 doi "https://doi.org/10.1016/j.actpha.2022.03.009" @default.
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