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• W4283775008 endingPage "1003" @default.
• W4283775008 startingPage "1003" @default.
• W4283775008 abstract "Colon cancer is considered as a complex disease that consists of metastatic seeding in early stages. Such disease is not simply caused by the action of a single RNA, but is associated with disorders of many kinds of RNAs and their regulation relationships. Hence, it is of great significance to study the complex regulatory roles among mRNAs, miRNAs and lncRNAs for further understanding the pathogenic mechanism of colon cancer. In this study, we constructed a heterogeneous network consisting of differentially expressed mRNAs, miRNAs and lncRNAs. This contains three kinds of vertices and six types of edges. All RNAs were re-divided into three categories, which were related, irrelevant and unlabeled. They were processed by dynamic excitation restart random walk (RW-DIR) for identifying colon cancer-related RNAs. Ten RNAs were finally obtained related to colon cancer, which were hsa-miR-2682-5p, hsa-miR-1277-3p, ANGPTL1, SLC22A18AS, FENDRR, PHLPP2, hsa-miR-302a-5p, APCDD1, MEX3A and hsa-miR-509-3-5p. Numerical experiments have indicated that the proposed network construction framework and the following RW-DIR algorithm are effective for identifying colon cancer-related RNAs, and this kind of analysis framework can also be easily extended to other diseases, effectively narrowing the scope of biological experimental research." @default.
• W4283775008 created "2022-07-03" @default.
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• W4283775008 date "2022-07-02" @default.
• W4283775008 modified "2023-10-16" @default.
• W4283775008 title "Identification of Colon Cancer-Related RNAs Based on Heterogeneous Networks and Random Walk" @default.
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• W4283775008 doi "https://doi.org/10.3390/biology11071003" @default.
• W4283775008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36101384" @default.
• W4283775008 hasPublicationYear "2022" @default.
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