FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283777186> ?p ?o ?g. }

• W4283777186 endingPage "143" @default.
• W4283777186 startingPage "125" @default.
• W4283777186 abstract "In presymptomatic amyotrophic lateral sclerosis (ALS), spinal motoneurons (MNs) have reduced firing patterns and synaptic excitation levels. Preliminary data indicated that in the SOD1 G93A mouse model of ALS, monosynaptic excitatory postsynaptic potentials (EPSPs) evoked in spinal MN by Ia proprioceptive afferent stimulation could be facilitated by trans-spinal direct current stimulation (tsDCS). However, which element of the Ia afferent-MN circuit is affected by tsDCS, and whether tsDCS-induced EPSP facilitation is a general phenomenon or specific to the superoxide dismutase type-1 (SOD1) Glycine to Alanine substitution at position 93 (G93A) mutation, remain to be determined. In this study, we have applied 15-minute tsDCS to the lumbar segments of presymptomatic SOD1 and wildtype (WT) mice and explored its impact on MN passive membrane properties, EPSP amplitude, and Ia afferent activity. While anodal tsDCS induced short-lasting EPSP facilitation in both SOD1 and WT mice, Ia afferent activity and passive membrane properties were altered only in SOD1 mice. Interestingly, EPSP amplitudes of SOD1 mice remained facilitated for at least 1 h after current application, but no long-lasting effect was observed in WT mice. Moreover, anodal tsDCS failed to induce any long-lasting changes in MN passive membrane properties in both SOD1 and WT mice. Conversely, cathodal tsDCS decreased Ia afferent induced EPSP amplitudes only during current application in SOD1 MNs, and no significant effects on Ia afferents excitability were observed. Our findings indicate the high susceptibility of SOD1 MNs to tsDCS and highlight the potential of this neuromodulation technique for the treatment of ALS." @default.
• W4283777186 created "2022-07-03" @default.
• W4283777186 creator A5055232685 @default.
• W4283777186 creator A5057481711 @default.
• W4283777186 creator A5064816109 @default.
• W4283777186 date "2022-08-01" @default.
• W4283777186 modified "2023-10-18" @default.
• W4283777186 title "Differential Effects of Invasive Anodal Trans-spinal Direct Current Stimulation on Monosynaptic Excitatory Postsynaptic Potentials, Ia Afferents Excitability, and Motoneuron Intrinsic Properties Between Superoxide Dismutase Type-1 Glycine to Alanine Substitution at Position 93 and Wildtype Mice" @default.
• W4283777186 cites W1512899315 @default.
• W4283777186 cites W1538003228 @default.
• W4283777186 cites W1571300248 @default.
• W4283777186 cites W1936114395 @default.
• W4283777186 cites W1978116811 @default.
• W4283777186 cites W1979903825 @default.
• W4283777186 cites W1981182334 @default.
• W4283777186 cites W1987794229 @default.
• W4283777186 cites W1988931872 @default.
• W4283777186 cites W1997621711 @default.
• W4283777186 cites W1999967173 @default.
• W4283777186 cites W2003346028 @default.
• W4283777186 cites W2017209077 @default.
• W4283777186 cites W2028856372 @default.
• W4283777186 cites W2033447200 @default.
• W4283777186 cites W2035334102 @default.
• W4283777186 cites W2036205071 @default.
• W4283777186 cites W2036898865 @default.
• W4283777186 cites W2047007033 @default.
• W4283777186 cites W2052332287 @default.
• W4283777186 cites W2058183189 @default.
• W4283777186 cites W2065300495 @default.
• W4283777186 cites W2068522066 @default.
• W4283777186 cites W2069922537 @default.
• W4283777186 cites W2070720564 @default.
• W4283777186 cites W2087500130 @default.
• W4283777186 cites W2099036911 @default.
• W4283777186 cites W2107486044 @default.
• W4283777186 cites W2114792780 @default.
• W4283777186 cites W2116403843 @default.
• W4283777186 cites W2122371015 @default.
• W4283777186 cites W2133232170 @default.
• W4283777186 cites W2134845797 @default.
• W4283777186 cites W2140594760 @default.
• W4283777186 cites W2146546145 @default.
• W4283777186 cites W2149223842 @default.
• W4283777186 cites W2168690368 @default.
• W4283777186 cites W2269366177 @default.
• W4283777186 cites W2275646918 @default.
• W4283777186 cites W2291221974 @default.
• W4283777186 cites W2297040637 @default.
• W4283777186 cites W2310204605 @default.
• W4283777186 cites W2507454632 @default.
• W4283777186 cites W2512493705 @default.
• W4283777186 cites W2553260896 @default.
• W4283777186 cites W2559228005 @default.
• W4283777186 cites W2597399186 @default.
• W4283777186 cites W2599550601 @default.
• W4283777186 cites W2616602548 @default.
• W4283777186 cites W2618039156 @default.
• W4283777186 cites W2754728829 @default.
• W4283777186 cites W2790800342 @default.
• W4283777186 cites W2794337710 @default.
• W4283777186 cites W2795357920 @default.
• W4283777186 cites W2809005511 @default.
• W4283777186 cites W2903415950 @default.
• W4283777186 cites W2920480868 @default.
• W4283777186 cites W2946303387 @default.
• W4283777186 cites W2962982115 @default.
• W4283777186 cites W2969907305 @default.
• W4283777186 cites W2973416962 @default.
• W4283777186 cites W2989170633 @default.
• W4283777186 cites W2993424755 @default.
• W4283777186 cites W3006375948 @default.
• W4283777186 cites W3032278529 @default.
• W4283777186 cites W3032721741 @default.
• W4283777186 cites W3042629348 @default.
• W4283777186 cites W3045881738 @default.
• W4283777186 cites W3048751138 @default.
• W4283777186 cites W3124057704 @default.
• W4283777186 cites W3169978105 @default.
• W4283777186 cites W3199184071 @default.
• W4283777186 cites W3205083903 @default.
• W4283777186 cites W4224241649 @default.
• W4283777186 cites W4224325294 @default.
• W4283777186 cites W4226344294 @default.
• W4283777186 doi "https://doi.org/10.1016/j.neuroscience.2022.06.035" @default.
• W4283777186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35792195" @default.
• W4283777186 hasPublicationYear "2022" @default.
• W4283777186 type Work @default.
• W4283777186 citedByCount "1" @default.
• W4283777186 countsByYear W42837771862022 @default.
• W4283777186 crossrefType "journal-article" @default.
• W4283777186 hasAuthorship W4283777186A5055232685 @default.
• W4283777186 hasAuthorship W4283777186A5057481711 @default.
• W4283777186 hasAuthorship W4283777186A5064816109 @default.
• W4283777186 hasConcept C112592302 @default.
• W4283777186 hasConcept C126322002 @default.
• W4283777186 hasConcept C169760540 @default.
• W4283777186 hasConcept C17077164 @default.

• next