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- W4283778840 abstract "Abstract Vesicle budding and fusion in eukaryotes depend on a suite of protein types, such as Arfs, Rabs, coats and SNAREs. Distinct paralogs of these proteins act at distinct intracellular locations, suggesting a link between gene duplication and the expansion of vesicle traffic pathways. Genome doubling, a common source of paralogous genes in fungi, provides an ideal setting in which to explore this link. Here we trace the fates of paralog doublets derived from the 100-Ma-old hybridization event that gave rise to the whole genome duplication clade of budding yeast. We find that paralog doublets involved in specific vesicle traffic functions and pathways are convergently retained across the entire clade. Vesicle coats and adaptors involved in secretory and early-endocytic pathways are retained as doublets, at rates several-fold higher than expected by chance. Proteins involved in later endocytic steps and intra-Golgi traffic, including the entire set of multi-subunit and coiled-coil tethers, have reverted to singletons. These patterns demonstrate that selection has acted to expand and diversify the yeast vesicle traffic apparatus, across species and time." @default.
- W4283778840 created "2022-07-03" @default.
- W4283778840 creator A5037925242 @default.
- W4283778840 creator A5082543435 @default.
- W4283778840 date "2022-07-02" @default.
- W4283778840 modified "2023-09-26" @default.
- W4283778840 title "Genome doubling enabled the expansion of yeast vesicle traffic pathways" @default.
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- W4283778840 doi "https://doi.org/10.1038/s41598-022-15419-9" @default.
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