Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283779264> ?p ?o ?g. }
- W4283779264 endingPage "114573" @default.
- W4283779264 startingPage "114573" @default.
- W4283779264 abstract "Pseudorabies virus (PrV) is one of the most important herpesviruses which can cause severe diseases in many mammals and some avian species. In recent years, repeated outbreaks of pseudorabies worldwide indicated an urgent need for new control measures. The results described in this study demonstrated that an extract prepared from the rhizome of Kaempferia galanga L (Kge), which consisted of flavonoids (2.82%), saccharides (61.37%), phenols (1.22%) and saponins (3.10%), possessed a potent anti-PrV activity. In PK-15 cells, Kge treatment inhibited PrV-induced cell death by more than 90% at a dose of 200 μg/mL. The 50% inhibitory concentration (IC50) was 55.85 μg/mL. In the PrV-infected mice treated with Kge, the survival rate was up to 60% at day 6 post-infection, while the infected mice without Kge treatment all died. The virus titers in the brains of the Kge-treated infected mice were significantly reduced. Kge treatment also alleviated the severity of the PrV-induced lesions in the heart, liver, spleen, lung and kidney. Kge exhibited immune-regulating activity through the regulation of cytokines (IFN-α, IFN-β, IL-4, IL-6 and TNF-α) in the serum of PrV-infected mice, suggesting that one possible mechanism of anti-PrV activity was through the regulation of immune function. These results suggested that Kge could be a promising drug candidate for treating PrV infections." @default.
- W4283779264 created "2022-07-03" @default.
- W4283779264 creator A5019444758 @default.
- W4283779264 creator A5037336737 @default.
- W4283779264 creator A5042785211 @default.
- W4283779264 creator A5043592553 @default.
- W4283779264 creator A5064308879 @default.
- W4283779264 creator A5065236570 @default.
- W4283779264 creator A5068053507 @default.
- W4283779264 creator A5070356958 @default.
- W4283779264 creator A5070812231 @default.
- W4283779264 creator A5081282024 @default.
- W4283779264 date "2022-09-01" @default.
- W4283779264 modified "2023-10-16" @default.
- W4283779264 title "Antiviral effect of an extract from Kaempferia galanga L. rhizome in mice infected with pseudorabies virus" @default.
- W4283779264 cites W1774354581 @default.
- W4283779264 cites W1895527819 @default.
- W4283779264 cites W1955347619 @default.
- W4283779264 cites W1966315678 @default.
- W4283779264 cites W1970574801 @default.
- W4283779264 cites W1977572216 @default.
- W4283779264 cites W1979411899 @default.
- W4283779264 cites W1986301216 @default.
- W4283779264 cites W1987328305 @default.
- W4283779264 cites W1991189992 @default.
- W4283779264 cites W1995852654 @default.
- W4283779264 cites W1995950743 @default.
- W4283779264 cites W1999095905 @default.
- W4283779264 cites W2013824956 @default.
- W4283779264 cites W2019072914 @default.
- W4283779264 cites W2029146518 @default.
- W4283779264 cites W2031406182 @default.
- W4283779264 cites W2032039622 @default.
- W4283779264 cites W2039237995 @default.
- W4283779264 cites W2039501259 @default.
- W4283779264 cites W2039778160 @default.
- W4283779264 cites W2041165983 @default.
- W4283779264 cites W2044402254 @default.
- W4283779264 cites W2051156715 @default.
- W4283779264 cites W2063311575 @default.
- W4283779264 cites W2064913788 @default.
- W4283779264 cites W2066539530 @default.
- W4283779264 cites W2096224929 @default.
- W4283779264 cites W2102285670 @default.
- W4283779264 cites W2105353585 @default.
- W4283779264 cites W2109493962 @default.
- W4283779264 cites W2118989770 @default.
- W4283779264 cites W2129415910 @default.
- W4283779264 cites W2137965676 @default.
- W4283779264 cites W2143360230 @default.
- W4283779264 cites W2153158939 @default.
- W4283779264 cites W2168314906 @default.
- W4283779264 cites W2308228209 @default.
- W4283779264 cites W2312511505 @default.
- W4283779264 cites W2316764847 @default.
- W4283779264 cites W2322028966 @default.
- W4283779264 cites W2495679092 @default.
- W4283779264 cites W2555060395 @default.
- W4283779264 cites W2568899563 @default.
- W4283779264 cites W2588647384 @default.
- W4283779264 cites W2593879388 @default.
- W4283779264 cites W2610867434 @default.
- W4283779264 cites W2623015503 @default.
- W4283779264 cites W2748210806 @default.
- W4283779264 cites W2781849109 @default.
- W4283779264 cites W2889299623 @default.
- W4283779264 cites W2937733380 @default.
- W4283779264 cites W2944714386 @default.
- W4283779264 cites W2976594871 @default.
- W4283779264 cites W3007888753 @default.
- W4283779264 cites W3021367353 @default.
- W4283779264 cites W3029706968 @default.
- W4283779264 cites W3088639750 @default.
- W4283779264 cites W4232692624 @default.
- W4283779264 cites W593308995 @default.
- W4283779264 doi "https://doi.org/10.1016/j.jviromet.2022.114573" @default.
- W4283779264 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35779703" @default.
- W4283779264 hasPublicationYear "2022" @default.
- W4283779264 type Work @default.
- W4283779264 citedByCount "3" @default.
- W4283779264 countsByYear W42837792642023 @default.
- W4283779264 crossrefType "journal-article" @default.
- W4283779264 hasAuthorship W4283779264A5019444758 @default.
- W4283779264 hasAuthorship W4283779264A5037336737 @default.
- W4283779264 hasAuthorship W4283779264A5042785211 @default.
- W4283779264 hasAuthorship W4283779264A5043592553 @default.
- W4283779264 hasAuthorship W4283779264A5064308879 @default.
- W4283779264 hasAuthorship W4283779264A5065236570 @default.
- W4283779264 hasAuthorship W4283779264A5068053507 @default.
- W4283779264 hasAuthorship W4283779264A5070356958 @default.
- W4283779264 hasAuthorship W4283779264A5070812231 @default.
- W4283779264 hasAuthorship W4283779264A5081282024 @default.
- W4283779264 hasConcept C159047783 @default.
- W4283779264 hasConcept C203014093 @default.
- W4283779264 hasConcept C2522874641 @default.
- W4283779264 hasConcept C2780931953 @default.
- W4283779264 hasConcept C2781092067 @default.
- W4283779264 hasConcept C86803240 @default.