FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283781941> ?p ?o ?g. }

• W4283781941 abstract "Metformin is a commonly used drug for the treatment of diabetes. Accumulating evidence suggests that it exerts anti-cancer effects in many cancers, including colorectal cancer. However, the underlying molecular mechanisms of colorectal cancer metastasis remain unclear. Colorectal cancer cell lines were treated with metformin, and cell proliferation, invasion, and migration were analyzed in vitro. The relationship between metformin and the AMPK–mTOR axis was assessed by Western blot analysis and transfection with small interfering RNA. A colorectal cancer xenograft mouse model was used to observe the effects of metformin on liver metastasis. Immunohistochemical analysis was performed on liver metastatic tumors. In in vitro experiments, metformin significantly inhibited the proliferation, migration, and invasion only in HCT116 and SW837 cells, but not in HCT8 and Lovo cells. Only in HCT116 and SW837, a change in AMPK–mTOR expression was observed in a dose-dependent manner. In colorectal cancer xenograft mice, the liver metastatic rate (10% vs. 50%, p = 0.05) and the number of liver metastatic nodules (0.1/body vs. 1.2/body, p = 0.04) were significantly lower in the metformin group. Tumor proliferation and EMT were decreased and apoptosis was promoted only in metastatic liver tumors of mice treated with metformin. The molecular mechanism of the anti-cancer effects of metformin involves repression of mTOR pathways via AMPK activation. Moreover, the differences in metformin sensitivity depend on the response of the AMPK–mTOR pathway to metformin. Our study provides a theoretical basis for the anti-metastatic treatment of colorectal cancer using metformin." @default.
• W4283781941 created "2022-07-03" @default.
• W4283781941 creator A5015403854 @default.
• W4283781941 creator A5015823083 @default.
• W4283781941 creator A5018112691 @default.
• W4283781941 creator A5029936226 @default.
• W4283781941 creator A5038634491 @default.
• W4283781941 creator A5038817476 @default.
• W4283781941 creator A5044749266 @default.
• W4283781941 creator A5083486893 @default.
• W4283781941 date "2022-07-02" @default.
• W4283781941 modified "2023-10-18" @default.
• W4283781941 title "Metformin inhibits the development and metastasis of colorectal cancer" @default.
• W4283781941 cites W1804369980 @default.
• W4283781941 cites W1853280320 @default.
• W4283781941 cites W1910603616 @default.
• W4283781941 cites W1965265512 @default.
• W4283781941 cites W1967349754 @default.
• W4283781941 cites W1990063646 @default.
• W4283781941 cites W1992894966 @default.
• W4283781941 cites W1994735160 @default.
• W4283781941 cites W1998912122 @default.
• W4283781941 cites W2005157575 @default.
• W4283781941 cites W2024105335 @default.
• W4283781941 cites W2026967508 @default.
• W4283781941 cites W2028083041 @default.
• W4283781941 cites W2054030645 @default.
• W4283781941 cites W2061955385 @default.
• W4283781941 cites W2064656431 @default.
• W4283781941 cites W2069887628 @default.
• W4283781941 cites W2078190084 @default.
• W4283781941 cites W2079537922 @default.
• W4283781941 cites W2085331940 @default.
• W4283781941 cites W2090836265 @default.
• W4283781941 cites W2093664485 @default.
• W4283781941 cites W2109834815 @default.
• W4283781941 cites W2118073504 @default.
• W4283781941 cites W2119437574 @default.
• W4283781941 cites W2126569401 @default.
• W4283781941 cites W2129577018 @default.
• W4283781941 cites W2138226825 @default.
• W4283781941 cites W2158080423 @default.
• W4283781941 cites W2173366817 @default.
• W4283781941 cites W2208233382 @default.
• W4283781941 cites W2288971050 @default.
• W4283781941 cites W2349230331 @default.
• W4283781941 cites W2549108333 @default.
• W4283781941 cites W2613571143 @default.
• W4283781941 cites W2619466894 @default.
• W4283781941 cites W2791798069 @default.
• W4283781941 cites W2806173386 @default.
• W4283781941 cites W2819238051 @default.
• W4283781941 cites W2895836456 @default.
• W4283781941 cites W2907606171 @default.
• W4283781941 cites W2955745348 @default.
• W4283781941 cites W2956314099 @default.
• W4283781941 cites W3037920944 @default.
• W4283781941 cites W3048690076 @default.
• W4283781941 cites W3118971387 @default.
• W4283781941 cites W4210952142 @default.
• W4283781941 cites W4251622665 @default.
• W4283781941 doi "https://doi.org/10.1007/s12032-022-01722-y" @default.
• W4283781941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35780231" @default.
• W4283781941 hasPublicationYear "2022" @default.
• W4283781941 type Work @default.
• W4283781941 citedByCount "4" @default.
• W4283781941 countsByYear W42837819412022 @default.
• W4283781941 countsByYear W42837819412023 @default.
• W4283781941 crossrefType "journal-article" @default.
• W4283781941 hasAuthorship W4283781941A5015403854 @default.
• W4283781941 hasAuthorship W4283781941A5015823083 @default.
• W4283781941 hasAuthorship W4283781941A5018112691 @default.
• W4283781941 hasAuthorship W4283781941A5029936226 @default.
• W4283781941 hasAuthorship W4283781941A5038634491 @default.
• W4283781941 hasAuthorship W4283781941A5038817476 @default.
• W4283781941 hasAuthorship W4283781941A5044749266 @default.
• W4283781941 hasAuthorship W4283781941A5083486893 @default.
• W4283781941 hasBestOaLocation W42837819412 @default.
• W4283781941 hasConcept C121608353 @default.
• W4283781941 hasConcept C126322002 @default.
• W4283781941 hasConcept C143998085 @default.
• W4283781941 hasConcept C184235292 @default.
• W4283781941 hasConcept C190283241 @default.
• W4283781941 hasConcept C2779013556 @default.
• W4283781941 hasConcept C2779306644 @default.
• W4283781941 hasConcept C2780124434 @default.
• W4283781941 hasConcept C2780323712 @default.
• W4283781941 hasConcept C502942594 @default.
• W4283781941 hasConcept C526805850 @default.
• W4283781941 hasConcept C55493867 @default.
• W4283781941 hasConcept C71924100 @default.
• W4283781941 hasConcept C86554907 @default.
• W4283781941 hasConcept C86803240 @default.
• W4283781941 hasConcept C95444343 @default.
• W4283781941 hasConcept C97029542 @default.
• W4283781941 hasConceptScore W4283781941C121608353 @default.
• W4283781941 hasConceptScore W4283781941C126322002 @default.
• W4283781941 hasConceptScore W4283781941C143998085 @default.
• W4283781941 hasConceptScore W4283781941C184235292 @default.
• W4283781941 hasConceptScore W4283781941C190283241 @default.

• next