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- W4283788082 abstract "Bile acid metabolites have been increasingly recognized as pleiotropic signaling molecules that regulate cardiovascular functions, but their role in mesenchymal stromal cells (MSC)-based therapy has never been investigated. It is found that overexpression of farnesoid X receptor (FXR), a main receptor for bile acids, improves the retention and cardioprotection of adipose tissue-derived MSC (ADSC) administered by intramyocardial injection in mice with myocardial infarction (MI), which shows enhanced antiapoptotic, proangiogenic, and antifibrotic effects. RNA sequencing, LC-MS/MS, and loss-of-function studies reveal that FXR overexpression promotes ADSC paracrine angiogenesis via Angptl4. FXR overexpression improves ADSC survival in vivo but fails in vitro. By performing bile acid-targeted metabolomics using ischemic heart tissue, 19 bile acids are identified. Among them, cholic acid and deoxycholic acid significantly increase Angptl4 secretion from ADSC overexpressing FXR and further improve their proangiogenic capability. Moreover, ADSC overexpressing FXR shows significantly lower apoptosis by upregulating Nqo-1 expression only in the presence of FXR ligands. Retinoid X receptor α is identified as a coactivator of FXR. It is first demonstrated that there is a bile acid pool in the myocardial microenvironment. Targeting the bile acid-FXR axis may be a novel strategy for improving the curative effect of MSC-based therapy for MI." @default.
- W4283788082 created "2022-07-04" @default.
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- W4283788082 date "2022-07-03" @default.
- W4283788082 modified "2023-10-02" @default.
- W4283788082 title "Mesenchymal Stromal Cells Overexpressing Farnesoid X Receptor Exert Cardioprotective Effects Against Acute Ischemic Heart Injury by Binding Endogenous Bile Acids" @default.
- W4283788082 cites W1842333848 @default.
- W4283788082 cites W1879790169 @default.
- W4283788082 cites W1967966071 @default.
- W4283788082 cites W1976621716 @default.
- W4283788082 cites W2025570171 @default.
- W4283788082 cites W2030672139 @default.
- W4283788082 cites W2045954655 @default.
- W4283788082 cites W2049460097 @default.
- W4283788082 cites W2053581007 @default.
- W4283788082 cites W2058095177 @default.
- W4283788082 cites W2062011959 @default.
- W4283788082 cites W2062121786 @default.
- W4283788082 cites W2062817574 @default.
- W4283788082 cites W2072822958 @default.
- W4283788082 cites W2073017976 @default.
- W4283788082 cites W2089182187 @default.
- W4283788082 cites W2097801360 @default.
- W4283788082 cites W2105259330 @default.
- W4283788082 cites W2116452468 @default.
- W4283788082 cites W2123950519 @default.
- W4283788082 cites W2125086964 @default.
- W4283788082 cites W2126047917 @default.
- W4283788082 cites W2148535164 @default.
- W4283788082 cites W2165760175 @default.
- W4283788082 cites W2168112142 @default.
- W4283788082 cites W2191965684 @default.
- W4283788082 cites W2264964555 @default.
- W4283788082 cites W2290598938 @default.
- W4283788082 cites W2300734873 @default.
- W4283788082 cites W2461407658 @default.
- W4283788082 cites W2572321150 @default.
- W4283788082 cites W2592901756 @default.
- W4283788082 cites W2605245050 @default.
- W4283788082 cites W2740083606 @default.
- W4283788082 cites W2763827226 @default.
- W4283788082 cites W2770747629 @default.
- W4283788082 cites W2781155055 @default.
- W4283788082 cites W2783862581 @default.
- W4283788082 cites W2784252303 @default.
- W4283788082 cites W2787647639 @default.
- W4283788082 cites W2793559013 @default.
- W4283788082 cites W2797922873 @default.
- W4283788082 cites W2801388770 @default.
- W4283788082 cites W2808912161 @default.
- W4283788082 cites W2810485115 @default.
- W4283788082 cites W2894803492 @default.
- W4283788082 cites W2900774558 @default.
- W4283788082 cites W2911886724 @default.
- W4283788082 cites W2912418307 @default.
- W4283788082 cites W2917155356 @default.
- W4283788082 cites W2955989795 @default.
- W4283788082 cites W2958319749 @default.
- W4283788082 cites W2970411693 @default.
- W4283788082 cites W2972223720 @default.
- W4283788082 cites W2990095623 @default.
- W4283788082 cites W2990949621 @default.
- W4283788082 cites W2992784349 @default.
- W4283788082 cites W3000813720 @default.
- W4283788082 cites W3003299879 @default.
- W4283788082 cites W3007239783 @default.
- W4283788082 cites W3012695764 @default.
- W4283788082 cites W3032363780 @default.
- W4283788082 cites W3033181066 @default.
- W4283788082 cites W3038279475 @default.
- W4283788082 cites W3040503741 @default.
- W4283788082 cites W3047535911 @default.
- W4283788082 cites W3048188989 @default.
- W4283788082 cites W3048670563 @default.
- W4283788082 cites W3095764625 @default.
- W4283788082 cites W3112849870 @default.
- W4283788082 cites W3133011606 @default.
- W4283788082 cites W3137314888 @default.
- W4283788082 cites W3212725035 @default.
- W4283788082 cites W4283788082 @default.
- W4283788082 cites W60074506 @default.
- W4283788082 doi "https://doi.org/10.1002/advs.202200431" @default.
- W4283788082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35780502" @default.
- W4283788082 hasPublicationYear "2022" @default.