FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283789736> ?p ?o ?g. }

• W4283789736 endingPage "154306" @default.
• W4283789736 startingPage "154306" @default.
• W4283789736 abstract "Acute kidney injury (AKI) is a common complication in clinical inpatients, and it continues a high morbidity and mortality rate despite many clinical treatment measures. AKI is triggered by infections, surgery, heavy metal exposure and drug side effects, but current chemical drugs often fall short of expectations for AKI treatment and have toxic side effects. Therefore, finding new interventions and treatments, especially of natural origin, is of remarkable clinical significance and application. The herbal monomer curcumin is a natural phenolic compound extracted from the plant Curcuma longa and showed various biological activities, including AKI. Furthermore, recent studies have shown that curcumin restores renal function by modulating the immune system and the release of inflammatory mediators, scavenging oxygen free radicals, reducing apoptosis and improving mitochondrial dynamics. However, curcumin has a low bioavailability, which limits its clinical application. For this reason, it is essential to investigate the therapeutic effects and molecular mechanisms of curcumin in AKI, as well as to improve its bioavailability for curcumin formulation development and clinical application.This review summarizes the sources, pharmacokinetics, and limitations in the clinical application of curcumin and explores methods to optimize its bioavailability using nanotechnology. In particular, the therapeutic effects and molecular mechanisms of curcumin on AKI are highlighted to provide a theoretical basis for AKI treatment in clinical practices.This review was specifically searched by means of a search of three databases (Web of Science, PubMed and Science Direct), till December 2021. Search terms were Curcumin, Acute kidney injury, AKI, Pharmacokinetics, Mitochondria and Nano formulations. The retrieved data followed PRISMA criteria (preferred reporting items for systematic review) RESULTS: Studies have shown that curcumin responded to AKI-induced renal injury and restored renal tubular epithelial cell function by affecting multiple signaling pathways in AKI models induced by factors such as cisplatin, lipopolysaccharide, ischemia/reperfusion, gentamicin and potassium dichromate. Curcumin was able to affect NF-κB signaling pathway and reduce the expression of IL-1β, IL-6, IL-8 and TNF-α, thus preventing renal inflammatory injury. In the prevention of renal tubular oxidative damage, curcumin reduced ROS production by activating the activity of Nrf2, HO-1 and PGC-1α. In addition, curcumin restored mitochondrial homeostasis by upregulating OPA1 and downregulating DRP1 expression, while reducing apoptosis by inhibiting the caspase-3 apoptotic pathway. In addition, due to the low bioavailability and poor absorption of curcumin in vivo, curcumin nanoformulations including nanoparticles, liposomes, and polymeric micelles are formulated to improve the bioavailability.This review provides new ideas for the use of curcumin in the prevention and treatment of AKI by modulating the molecular targets of several different cellular signaling pathways." @default.
• W4283789736 created "2022-07-05" @default.
• W4283789736 creator A5005769195 @default.
• W4283789736 creator A5006254788 @default.
• W4283789736 creator A5008788902 @default.
• W4283789736 creator A5014679890 @default.
• W4283789736 creator A5022299456 @default.
• W4283789736 creator A5030021829 @default.
• W4283789736 creator A5038143090 @default.
• W4283789736 creator A5046436076 @default.
• W4283789736 creator A5052119050 @default.
• W4283789736 creator A5060553443 @default.
• W4283789736 creator A5079137368 @default.
• W4283789736 creator A5090865944 @default.
• W4283789736 date "2022-09-01" @default.
• W4283789736 modified "2023-10-14" @default.
• W4283789736 title "Role of curcumin in the treatment of acute kidney injury: research challenges and opportunities" @default.
• W4283789736 cites W1735882853 @default.
• W4283789736 cites W1965920807 @default.
• W4283789736 cites W1972179974 @default.
• W4283789736 cites W1993915524 @default.
• W4283789736 cites W2001356850 @default.
• W4283789736 cites W2052471590 @default.
• W4283789736 cites W2056557856 @default.
• W4283789736 cites W2071847433 @default.
• W4283789736 cites W2080731177 @default.
• W4283789736 cites W2126894693 @default.
• W4283789736 cites W2136932375 @default.
• W4283789736 cites W2137050305 @default.
• W4283789736 cites W2146081758 @default.
• W4283789736 cites W2146552067 @default.
• W4283789736 cites W2154049977 @default.
• W4283789736 cites W2165640077 @default.
• W4283789736 cites W2319528167 @default.
• W4283789736 cites W2411087675 @default.
• W4283789736 cites W2478177147 @default.
• W4283789736 cites W2486904375 @default.
• W4283789736 cites W2534857447 @default.
• W4283789736 cites W2559816317 @default.
• W4283789736 cites W2588605196 @default.
• W4283789736 cites W2588980441 @default.
• W4283789736 cites W2592540981 @default.
• W4283789736 cites W2607139066 @default.
• W4283789736 cites W2633100912 @default.
• W4283789736 cites W2728754842 @default.
• W4283789736 cites W2730961047 @default.
• W4283789736 cites W2745006122 @default.
• W4283789736 cites W2746831597 @default.
• W4283789736 cites W2749151718 @default.
• W4283789736 cites W2750841772 @default.
• W4283789736 cites W2761905894 @default.
• W4283789736 cites W2767766003 @default.
• W4283789736 cites W2770241103 @default.
• W4283789736 cites W2770423246 @default.
• W4283789736 cites W2770729810 @default.
• W4283789736 cites W2773801097 @default.
• W4283789736 cites W2777340293 @default.
• W4283789736 cites W2778834997 @default.
• W4283789736 cites W2788835551 @default.
• W4283789736 cites W2790234187 @default.
• W4283789736 cites W2791998294 @default.
• W4283789736 cites W2793066160 @default.
• W4283789736 cites W2793762730 @default.
• W4283789736 cites W2794354802 @default.
• W4283789736 cites W2795880104 @default.
• W4283789736 cites W2795925070 @default.
• W4283789736 cites W2804155996 @default.
• W4283789736 cites W2807676692 @default.
• W4283789736 cites W2885865442 @default.
• W4283789736 cites W2888926122 @default.
• W4283789736 cites W2892878753 @default.
• W4283789736 cites W2893289712 @default.
• W4283789736 cites W2896944427 @default.
• W4283789736 cites W2901739897 @default.
• W4283789736 cites W2901824796 @default.
• W4283789736 cites W2907014989 @default.
• W4283789736 cites W2907855283 @default.
• W4283789736 cites W2910421569 @default.
• W4283789736 cites W2913562894 @default.
• W4283789736 cites W2929510384 @default.
• W4283789736 cites W2937652823 @default.
• W4283789736 cites W2945213030 @default.
• W4283789736 cites W2945487790 @default.
• W4283789736 cites W2947524960 @default.
• W4283789736 cites W2950811882 @default.
• W4283789736 cites W2951593518 @default.
• W4283789736 cites W2952808930 @default.
• W4283789736 cites W2972100969 @default.
• W4283789736 cites W2972284379 @default.
• W4283789736 cites W2973289708 @default.
• W4283789736 cites W2979405293 @default.
• W4283789736 cites W2996969437 @default.
• W4283789736 cites W2999283258 @default.
• W4283789736 cites W3003209420 @default.
• W4283789736 cites W3004046724 @default.
• W4283789736 cites W3005861947 @default.
• W4283789736 cites W3007878186 @default.
• W4283789736 cites W3011071407 @default.

• next