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- W4283790030 endingPage "1589" @default.
- W4283790030 startingPage "1589" @default.
- W4283790030 abstract "Cancer is one of the leading causes of death worldwide. There are only limited treatment strategies that can be applied to treat cancer, including surgical resection, chemotherapy, and radiotherapy, but these have only limited effectiveness. Developing a new drug for cancer therapy is protracted, costly, and inefficient. Recently, drug repurposing has become a rising research field to provide new meaning for an old drug. By searching a drug repurposing database ReDO_DB, a brief list of anesthetic/sedative drugs, such as haloperidol, ketamine, lidocaine, midazolam, propofol, and valproic acid, are shown to possess anti-cancer properties. Therefore, in the current review, we will provide a general overview of the anti-cancer mechanisms of these anesthetic/sedative drugs and explore the potential underlying signaling pathways and clinical application of these drugs applied individually or in combination with other anti-cancer agents." @default.
- W4283790030 created "2022-07-05" @default.
- W4283790030 creator A5000260954 @default.
- W4283790030 creator A5013632972 @default.
- W4283790030 creator A5039928284 @default.
- W4283790030 creator A5061807688 @default.
- W4283790030 date "2022-07-04" @default.
- W4283790030 modified "2023-10-17" @default.
- W4283790030 title "Drug Repurposing: The Mechanisms and Signaling Pathways of Anti-Cancer Effects of Anesthetics" @default.
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