Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283796237> ?p ?o ?g. }
- W4283796237 abstract "ABSTRACT Cell fate determination is a necessary and tightly regulated process for producing different cell types and structures during development. Cranial neural crest cells (CNCCs) are unique to vertebrate embryos and emerge from the neural plate borders into multiple cell lineages that differentiate into bone, cartilage, neurons and glial cells. We have previously reported that Irf6 genetically interacts with Twist1 during CNCC-derived tissue formation. Here, we have investigated the mechanistic role of Twist1 and Irf6 at early stages of craniofacial development. Our data indicate that TWIST1 is expressed in endocytic vesicles at the apical surface and interacts with β/δ-catenins during neural tube closure, and Irf6 is involved in defining neural fold borders by restricting AP2α expression. Twist1 suppresses Irf6 and other epithelial genes in CNCCs during the epithelial-to-mesenchymal transition (EMT) process and cell migration. Conversely, a loss of Twist1 leads to a sustained expression of epithelial and cell adhesion markers in migratory CNCCs. Disruption of TWIST1 phosphorylation in vivo leads to epidermal blebbing, edema, neural tube defects and CNCC-derived structural abnormalities. Altogether, this study describes a previously uncharacterized function of mammalian Twist1 and Irf6 in the neural tube and CNCCs, and provides new target genes for Twist1 that are involved in cytoskeletal remodeling." @default.
- W4283796237 created "2022-07-05" @default.
- W4283796237 creator A5000339160 @default.
- W4283796237 creator A5009048424 @default.
- W4283796237 creator A5010495911 @default.
- W4283796237 creator A5010996257 @default.
- W4283796237 creator A5015805328 @default.
- W4283796237 creator A5018007718 @default.
- W4283796237 creator A5020534674 @default.
- W4283796237 creator A5029218936 @default.
- W4283796237 creator A5040718777 @default.
- W4283796237 creator A5044858589 @default.
- W4283796237 creator A5054286392 @default.
- W4283796237 creator A5056987500 @default.
- W4283796237 creator A5069808726 @default.
- W4283796237 creator A5079113368 @default.
- W4283796237 creator A5079396625 @default.
- W4283796237 creator A5080942921 @default.
- W4283796237 creator A5081766414 @default.
- W4283796237 date "2022-08-01" @default.
- W4283796237 modified "2023-10-15" @default.
- W4283796237 title "TWIST1 interacts with β/δ-catenins during neural tube development and regulates fate transition in cranial neural crest cells" @default.
- W4283796237 cites W1481472040 @default.
- W4283796237 cites W1532872348 @default.
- W4283796237 cites W1609321187 @default.
- W4283796237 cites W1835943580 @default.
- W4283796237 cites W1912873449 @default.
- W4283796237 cites W1963766715 @default.
- W4283796237 cites W1964081206 @default.
- W4283796237 cites W1972462110 @default.
- W4283796237 cites W1980404014 @default.
- W4283796237 cites W1982202488 @default.
- W4283796237 cites W1983176252 @default.
- W4283796237 cites W1984792106 @default.
- W4283796237 cites W1987571337 @default.
- W4283796237 cites W1989496672 @default.
- W4283796237 cites W1993221038 @default.
- W4283796237 cites W1994395370 @default.
- W4283796237 cites W1999671240 @default.
- W4283796237 cites W2001181578 @default.
- W4283796237 cites W2008043065 @default.
- W4283796237 cites W2008458502 @default.
- W4283796237 cites W2018207073 @default.
- W4283796237 cites W2018824203 @default.
- W4283796237 cites W2025584872 @default.
- W4283796237 cites W2032927785 @default.
- W4283796237 cites W2049416925 @default.
- W4283796237 cites W2052658057 @default.
- W4283796237 cites W2053699349 @default.
- W4283796237 cites W2054541267 @default.
- W4283796237 cites W2063537682 @default.
- W4283796237 cites W2069152213 @default.
- W4283796237 cites W2073650418 @default.
- W4283796237 cites W2075328770 @default.
- W4283796237 cites W2084430874 @default.
- W4283796237 cites W2087415206 @default.
- W4283796237 cites W2090544616 @default.
- W4283796237 cites W2091154399 @default.
- W4283796237 cites W2095239060 @default.
- W4283796237 cites W2102395429 @default.
- W4283796237 cites W2103597610 @default.
- W4283796237 cites W2107400911 @default.
- W4283796237 cites W2107733361 @default.
- W4283796237 cites W2111334408 @default.
- W4283796237 cites W2125723268 @default.
- W4283796237 cites W2129009186 @default.
- W4283796237 cites W2148179388 @default.
- W4283796237 cites W2156952955 @default.
- W4283796237 cites W2157292201 @default.
- W4283796237 cites W2161728771 @default.
- W4283796237 cites W2171092698 @default.
- W4283796237 cites W2228243163 @default.
- W4283796237 cites W2292571646 @default.
- W4283796237 cites W2315856598 @default.
- W4283796237 cites W2323198694 @default.
- W4283796237 cites W2507575699 @default.
- W4283796237 cites W2563238470 @default.
- W4283796237 cites W2572094334 @default.
- W4283796237 cites W2609172188 @default.
- W4283796237 cites W2741934342 @default.
- W4283796237 cites W2754427838 @default.
- W4283796237 cites W2762693247 @default.
- W4283796237 cites W2789017128 @default.
- W4283796237 cites W2899042102 @default.
- W4283796237 cites W2900898267 @default.
- W4283796237 cites W2901344735 @default.
- W4283796237 cites W2913261919 @default.
- W4283796237 cites W2914442827 @default.
- W4283796237 cites W2948517648 @default.
- W4283796237 cites W2999266150 @default.
- W4283796237 cites W3046585832 @default.
- W4283796237 cites W3092459520 @default.
- W4283796237 cites W3113354915 @default.
- W4283796237 cites W3124375652 @default.
- W4283796237 cites W3125978548 @default.
- W4283796237 cites W3126906055 @default.
- W4283796237 cites W3127954364 @default.
- W4283796237 cites W3179578834 @default.
- W4283796237 cites W3213878098 @default.
- W4283796237 cites W4211233744 @default.