FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283801189> ?p ?o ?g. }

• W4283801189 abstract "Abstract We report Brownian dynamics simulation results with the specific goal to identify key parameters controlling the experimentally measurable characteristics of protein tags on a dsDNA construct translocating through a double nanopore setup. First, we validate the simulation scheme in silico by reproducing and explaining the physical origin of the asymmetric experimental dwell time distributions of the oligonucleotide flap markers on a 48 kbp long dsDNA at the left and the right pore. We study the effect of the electric field inside and beyond the pores, critical to discriminate the protein tags based on their effective charges and masses revealed through a generic power-law dependence of the average dwell time at each pore. The simulation protocols monitor piecewise dynamics at a sub-nanometer length scale and explain the disparate velocity using the concepts of nonequilibrium tension propagation theory. We further justify the model and the chosen simulation parameters by calculating the Péclet number which is in close agreement with the experiment. We demonstrate that our carefully chosen simulation strategies can serve as a powerful tool to discriminate different types of neutral and charged tags of different origins on a dsDNA construct in terms of their physical characteristics and can provide insights to increase both the efficiency and accuracy of an experimental dual-nanopore setup." @default.
• W4283801189 created "2022-07-05" @default.
• W4283801189 creator A5005999411 @default.
• W4283801189 creator A5008026871 @default.
• W4283801189 creator A5049536483 @default.
• W4283801189 creator A5056489921 @default.
• W4283801189 creator A5073844466 @default.
• W4283801189 creator A5085474025 @default.
• W4283801189 date "2022-07-04" @default.
• W4283801189 modified "2023-09-30" @default.
• W4283801189 title "Discriminating protein tags on a dsDNA construct using a Dual Nanopore Device" @default.
• W4283801189 cites W1992867061 @default.
• W4283801189 cites W2001654715 @default.
• W4283801189 cites W2010834748 @default.
• W4283801189 cites W2029667189 @default.
• W4283801189 cites W2041699873 @default.
• W4283801189 cites W2049003314 @default.
• W4283801189 cites W2061568414 @default.
• W4283801189 cites W2092552916 @default.
• W4283801189 cites W2132858529 @default.
• W4283801189 cites W2156242741 @default.
• W4283801189 cites W2314378301 @default.
• W4283801189 cites W2318868241 @default.
• W4283801189 cites W2319363320 @default.
• W4283801189 cites W2329887558 @default.
• W4283801189 cites W2342867357 @default.
• W4283801189 cites W2346680365 @default.
• W4283801189 cites W2557322836 @default.
• W4283801189 cites W2748557868 @default.
• W4283801189 cites W2750394448 @default.
• W4283801189 cites W2750798189 @default.
• W4283801189 cites W2767950187 @default.
• W4283801189 cites W2896863072 @default.
• W4283801189 cites W2903273372 @default.
• W4283801189 cites W2906493741 @default.
• W4283801189 cites W2914364223 @default.
• W4283801189 cites W2952115742 @default.
• W4283801189 cites W2994651393 @default.
• W4283801189 cites W3012186857 @default.
• W4283801189 cites W3083834454 @default.
• W4283801189 cites W3104285247 @default.
• W4283801189 cites W3108422731 @default.
• W4283801189 cites W3158010089 @default.
• W4283801189 cites W3169931109 @default.
• W4283801189 cites W3176811555 @default.
• W4283801189 cites W3200094841 @default.
• W4283801189 cites W4220739013 @default.
• W4283801189 cites W4240542582 @default.
• W4283801189 doi "https://doi.org/10.1038/s41598-022-14609-9" @default.
• W4283801189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35787637" @default.
• W4283801189 hasPublicationYear "2022" @default.
• W4283801189 type Work @default.
• W4283801189 citedByCount "1" @default.
• W4283801189 countsByYear W42838011892023 @default.
• W4283801189 crossrefType "journal-article" @default.
• W4283801189 hasAuthorship W4283801189A5005999411 @default.
• W4283801189 hasAuthorship W4283801189A5008026871 @default.
• W4283801189 hasAuthorship W4283801189A5049536483 @default.
• W4283801189 hasAuthorship W4283801189A5056489921 @default.
• W4283801189 hasAuthorship W4283801189A5073844466 @default.
• W4283801189 hasAuthorship W4283801189A5085474025 @default.
• W4283801189 hasBestOaLocation W42838011891 @default.
• W4283801189 hasConcept C104317684 @default.
• W4283801189 hasConcept C112401455 @default.
• W4283801189 hasConcept C11413529 @default.
• W4283801189 hasConcept C121332964 @default.
• W4283801189 hasConcept C121864883 @default.
• W4283801189 hasConcept C130603088 @default.
• W4283801189 hasConcept C134306372 @default.
• W4283801189 hasConcept C141795571 @default.
• W4283801189 hasConcept C151637689 @default.
• W4283801189 hasConcept C164660894 @default.
• W4283801189 hasConcept C171250308 @default.
• W4283801189 hasConcept C185592680 @default.
• W4283801189 hasConcept C186060115 @default.
• W4283801189 hasConcept C192562407 @default.
• W4283801189 hasConcept C199360897 @default.
• W4283801189 hasConcept C2775905019 @default.
• W4283801189 hasConcept C2780801425 @default.
• W4283801189 hasConcept C33923547 @default.
• W4283801189 hasConcept C41008148 @default.
• W4283801189 hasConcept C55493867 @default.
• W4283801189 hasConcept C62520636 @default.
• W4283801189 hasConcept C70410870 @default.
• W4283801189 hasConcept C71924100 @default.
• W4283801189 hasConcept C86803240 @default.
• W4283801189 hasConceptScore W4283801189C104317684 @default.
• W4283801189 hasConceptScore W4283801189C112401455 @default.
• W4283801189 hasConceptScore W4283801189C11413529 @default.
• W4283801189 hasConceptScore W4283801189C121332964 @default.
• W4283801189 hasConceptScore W4283801189C121864883 @default.
• W4283801189 hasConceptScore W4283801189C130603088 @default.
• W4283801189 hasConceptScore W4283801189C134306372 @default.
• W4283801189 hasConceptScore W4283801189C141795571 @default.
• W4283801189 hasConceptScore W4283801189C151637689 @default.
• W4283801189 hasConceptScore W4283801189C164660894 @default.
• W4283801189 hasConceptScore W4283801189C171250308 @default.
• W4283801189 hasConceptScore W4283801189C185592680 @default.
• W4283801189 hasConceptScore W4283801189C186060115 @default.
• W4283801189 hasConceptScore W4283801189C192562407 @default.

• next